Novel Probiotic Bacterium Rouxiella badensis subsp. acadiensis (Canan SV-53) Modulates Gut Immunity through Epigenetic Mechanisms
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Probiotic and Prebiotic Solution Preparation
2.3. Study Design
2.3.1. Probiotic-Prebiotic Experiment
2.3.2. Heat-Inactivated Probiotic Experiment
2.4. Histological Sections Preparation
2.5. Identification of IgA, IgG, IL-17A, IL-6, IL-23, and IL-10 Producing Cell Populations by Immunofluorescence
2.6. Determination of IgA, IgG, IL-17A, IL-6, IL-23, and IL-10 Concentrations by ELISA
2.7. Determination of miRNA Expression by Real-Time Quantitative Reverse Transcription PCR (RT-qPCR)
2.8. Gut Microbiome Analysis
2.9. Methylome-Wide Profiling and Data Analysis
2.10. Statistical Analysis
3. Results
3.1. Effect of Probiotic and Prebiotic Intake on Mucosal Immunity
3.2. Effect of Probiotic and Prebiotic Intake on the Expression of Selected Cytokines and miRNAs
3.3. Effect of the Probiotic and Prebiotic Intake on the Gut Microbiome
3.4. Effect of Heat-Inactivated SV-53 Intake on Mucosal Immunity
3.5. Effect of Heat-Inactivated SV-53 Intake on the Expression of Selected Cytokines and miRNAs
3.6. Effect of Heat-Inactivated SV-53 on DNA Methylation Status
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Shahbazi, R.; Yasavoli-Sharahi, H.; Mallet, J.-F.; Sharifzad, F.; Alsadi, N.; Cuenin, C.; Cahais, V.; Chung, F.F.-L.; Herceg, Z.; Matar, C. Novel Probiotic Bacterium Rouxiella badensis subsp. acadiensis (Canan SV-53) Modulates Gut Immunity through Epigenetic Mechanisms. Microorganisms 2023, 11, 2456. https://doi.org/10.3390/microorganisms11102456
Shahbazi R, Yasavoli-Sharahi H, Mallet J-F, Sharifzad F, Alsadi N, Cuenin C, Cahais V, Chung FF-L, Herceg Z, Matar C. Novel Probiotic Bacterium Rouxiella badensis subsp. acadiensis (Canan SV-53) Modulates Gut Immunity through Epigenetic Mechanisms. Microorganisms. 2023; 11(10):2456. https://doi.org/10.3390/microorganisms11102456
Chicago/Turabian StyleShahbazi, Roghayeh, Hamed Yasavoli-Sharahi, Jean-François Mallet, Farzaneh Sharifzad, Nawal Alsadi, Cyrille Cuenin, Vincent Cahais, Felicia Fei-Lei Chung, Zdenko Herceg, and Chantal Matar. 2023. "Novel Probiotic Bacterium Rouxiella badensis subsp. acadiensis (Canan SV-53) Modulates Gut Immunity through Epigenetic Mechanisms" Microorganisms 11, no. 10: 2456. https://doi.org/10.3390/microorganisms11102456
APA StyleShahbazi, R., Yasavoli-Sharahi, H., Mallet, J.-F., Sharifzad, F., Alsadi, N., Cuenin, C., Cahais, V., Chung, F. F.-L., Herceg, Z., & Matar, C. (2023). Novel Probiotic Bacterium Rouxiella badensis subsp. acadiensis (Canan SV-53) Modulates Gut Immunity through Epigenetic Mechanisms. Microorganisms, 11(10), 2456. https://doi.org/10.3390/microorganisms11102456