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Inosine Pranobex Significantly Decreased the Case-Fatality Rate among PCR Positive Elderly with SARS-CoV-2 at Three Nursing Homes in the Czech Republic

1
Department for Tropical, Travel Medicine and Immunization, Institute of Postgraduate Health Education, 100 05 Prague, Czech Republic
2
Department of Psychology, Faculty of Philosophy and Arts, Trnava University, 918 43 Trnava, Slovakia
3
Domov Důchodců Litovel, 784 01 Litovel, Czech Republic
4
Sanatorium Topas, 534 01 Holice, Czech Republic
5
Senior dům Beránek Úpice, 542 32 Úpice, Czech Republic
6
Department of Pharmacology, Third Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Pathogens 2020, 9(12), 1055; https://doi.org/10.3390/pathogens9121055
Received: 12 November 2020 / Revised: 13 December 2020 / Accepted: 14 December 2020 / Published: 16 December 2020
(This article belongs to the Section Immunological Responses and Immune Defense Mechanisms)
During the COVID-19 pandemic, the elderly population has been disproportionately affected, especially those in nursing homes (NH). Inosine pranobex (IP) has been previously demonstrated to be effective in treating acute viral respiratory infections. In three NH experiencing the SARS-CoV-2 virus epidemic, we started treatment with IP as soon as clients tested PCR+. In Litovel, CZ, the difference in case-fatality rate (CFR) for the PCR+ group using vs. not using IP was statistically significant, and the odds ratio (OR) was 7.2. When comparing all those taking IP in the three NH vs. the non-drug PCR+ group in Litovel, the odds ratio was lower for all three NH, but still significant at 2.9. The CFR in all three tested NHs, age range 75–84, compared to the CFR in all NHs in the Czech Republic, was significantly reduced (7.5% vs. 18%) (OR: 2.8); there was also a significant difference across all age groups (OR: 1.7). In our study with 301 residents, the CFR was significantly reduced (OR: 2.8) to 11.9% (17/142) in comparison to a study in Ireland with 27.6% (211/764). We think the effect of IP was significant in this reduction; nevertheless, these are preliminary results that need larger-scale trials on COVID-19 patients. View Full-Text
Keywords: inosine pranobex; natural killer cells; acute respiratory viral infection; treatment; COVID-19; nursing homes; case-fatality rate inosine pranobex; natural killer cells; acute respiratory viral infection; treatment; COVID-19; nursing homes; case-fatality rate
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MDPI and ACS Style

Beran, J.; Špajdel, M.; Katzerová, V.; Holoušová, A.; Malyš, J.; Finger Rousková, J.; Slíva, J. Inosine Pranobex Significantly Decreased the Case-Fatality Rate among PCR Positive Elderly with SARS-CoV-2 at Three Nursing Homes in the Czech Republic. Pathogens 2020, 9, 1055. https://doi.org/10.3390/pathogens9121055

AMA Style

Beran J, Špajdel M, Katzerová V, Holoušová A, Malyš J, Finger Rousková J, Slíva J. Inosine Pranobex Significantly Decreased the Case-Fatality Rate among PCR Positive Elderly with SARS-CoV-2 at Three Nursing Homes in the Czech Republic. Pathogens. 2020; 9(12):1055. https://doi.org/10.3390/pathogens9121055

Chicago/Turabian Style

Beran, Jiří; Špajdel, Marian; Katzerová, Věra; Holoušová, Alena; Malyš, Jan; Finger Rousková, Jana; Slíva, Jiří. 2020. "Inosine Pranobex Significantly Decreased the Case-Fatality Rate among PCR Positive Elderly with SARS-CoV-2 at Three Nursing Homes in the Czech Republic" Pathogens 9, no. 12: 1055. https://doi.org/10.3390/pathogens9121055

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