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Emerging Roles of Heparanase in Viral Pathogenesis

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60612, USA
Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA
Author to whom correspondence should be addressed.
Pathogens 2017, 6(3), 43;
Received: 25 August 2017 / Revised: 14 September 2017 / Accepted: 15 September 2017 / Published: 18 September 2017
Heparan sulfate (HS) is ubiquitously expressed on mammalian cells. It is a polysaccharide that binds growth factors, cytokines, and chemokines, and thereby controls several important physiological functions. Ironically, many human pathogens including viruses interact with it for adherence to host cells. HS functions can be regulated by selective modifications and/or selective cleavage of the sugar chains from the cell surface. In mammals, heparanase (HPSE) is the only known enzyme capable of regulating HS functions via a selective endoglycosidase activity that cleaves polymeric HS chains at internal sites. During homeostasis, HPSE expression and its endoglycosidase activity are tightly regulated; however, under stress conditions, including infection, its expression may be upregulated, which could contribute directly to the onset of several disease pathologies. Here we focus on viral infections exemplified by herpes simplex virus, dengue virus, human papillomavirus, respiratory syncytial virus, adenovirus, hepatitis C virus, and porcine respiratory and reproductive syncytial virus to summarize recent advances in understanding the highly significant, but emerging roles, of the enzyme HPSE in viral infection, spread and pathogenesis. View Full-Text
Keywords: herpes simplex virus; heparan sulfate; heparanase herpes simplex virus; heparan sulfate; heparanase
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Thakkar, N.; Yadavalli, T.; Jaishankar, D.; Shukla, D. Emerging Roles of Heparanase in Viral Pathogenesis. Pathogens 2017, 6, 43.

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