Next Article in Journal / Special Issue
Host-Viral Interactions: Role of Pattern Recognition Receptors (PRRs) in Human Pneumovirus Infections
Previous Article in Journal
Use of a Th1 Stimulator Adjuvant for Vaccination against Neospora caninum Infection in the Pregnant Mouse Model
Previous Article in Special Issue
Humanized Mouse Models of Epstein-Barr Virus Infection and Associated Diseases
Open AccessReview

Regenerative Inflammation: Lessons from Drosophila Intestinal Epithelium in Health and Disease

Department of Biological Sciences, University of Cyprus, Nicosia 1678, Cyprus
*
Author to whom correspondence should be addressed.
Pathogens 2013, 2(2), 209-231; https://doi.org/10.3390/pathogens2020209
Received: 1 February 2013 / Revised: 18 March 2013 / Accepted: 22 March 2013 / Published: 2 April 2013
(This article belongs to the Special Issue Pathogen Infection Models)
Intestinal inflammation is widely recognized as a pivotal player in health and disease. Defined cytologically as the infiltration of leukocytes in the lamina propria layer of the intestine, it can damage the epithelium and, on a chronic basis, induce inflammatory bowel disease and potentially cancer. The current view thus dictates that blood cell infiltration is the instigator of intestinal inflammation and tumor-promoting inflammation. This is based partially on work in humans and mice showing that intestinal damage during microbially mediated inflammation activates phagocytic cells and lymphocytes that secrete inflammatory signals promoting tissue damage and tumorigenesis. Nevertheless, extensive parallel work in the Drosophila midgut shows that intestinal epithelium damage induces inflammatory signals and growth factors acting mainly in a paracrine manner to induce intestinal stem cell proliferation and tumor formation when genetically predisposed. This is accomplished without any apparent need to involve Drosophila hemocytes. Therefore, recent work on Drosophila host defense to infection by expanding its main focus on systemic immunity signaling pathways to include the study of organ homeostasis in health and disease shapes a new notion that epithelially emanating cytokines and growth factors can directly act on the intestinal stem cell niche to promote “regenerative inflammation” and potentially cancer. View Full-Text
Keywords: Drosophila; innate immunity; inflammation; cancer; regeneration; intestine Drosophila; innate immunity; inflammation; cancer; regeneration; intestine
Show Figures

Graphical abstract

MDPI and ACS Style

Panayidou, S.; Apidianakis, Y. Regenerative Inflammation: Lessons from Drosophila Intestinal Epithelium in Health and Disease. Pathogens 2013, 2, 209-231.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop