Next Article in Journal
From Exit to Entry: Long-term Survival and Transmission of Salmonella
Next Article in Special Issue
Epstein-Barr Virus Sequence Variation—Biology and Disease
Previous Article in Journal / Special Issue
Hypomethylation and Over-Expression of the Beta Isoform of BLIMP1 is Induced by Epstein-Barr Virus Infection of B Cells; Potential Implications for the Pathogenesis of EBV-Associated Lymphomas
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pathogens
Volume 1
Issue 2
10.3390/pathogens1020102
pathogens-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus

by
Wei Zhang
† and
Shou-Jiang Gao
*
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA90033, USA
*
Author to whom correspondence should be addressed.
†
Current address: Department of Genetics, Yale School of Medicine, New Haven, CT06510, USA.
Pathogens 2012, 1(2), 102-127; https://doi.org/10.3390/pathogens1020102
Submission received: 2 September 2012 / Revised: 11 October 2012 / Accepted: 13 October 2012 / Published: 22 October 2012
(This article belongs to the Special Issue Infection and Cancer)
Versions Notes

Abstract

As obligate intracellular pathogens, viruses depend on the host cell machinery to complete their life cycle. Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus causally linked to the development of Kaposi’s sarcoma and several other lymphoproliferative malignancies. KSHV entry into cells is tightly regulated by diverse viral and cellular factors. In particular, KSHV actively engages cellular integrins and ubiquitination pathways for successful infection. Emerging evidence suggests that KSHV hijacks both actin and microtubule cytoskeletons at different phases during entry into cells. Here, we review recent findings on the early events during primary infection of KSHV and its closely related primate homolog rhesus rhadinovirus with highlights on the regulation of cellular cytoskeletons and signaling pathways that are important for this phase of virus life cycle.
Keywords: Kaposi’s Sarcoma-Associated Herpesvirus (KSHV); Rhesus Rhadinovirus (RRV); virus entry; endocytosis; actin; microtubule; integrin; cellular signaling; ubiquitination Kaposi’s Sarcoma-Associated Herpesvirus (KSHV); Rhesus Rhadinovirus (RRV); virus entry; endocytosis; actin; microtubule; integrin; cellular signaling; ubiquitination

Share and Cite

MDPI and ACS Style

Zhang, W.; Gao, S.-J. Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus. Pathogens 2012, 1, 102-127. https://doi.org/10.3390/pathogens1020102

AMA Style

Zhang W, Gao S-J. Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus. Pathogens. 2012; 1(2):102-127. https://doi.org/10.3390/pathogens1020102

Chicago/Turabian Style

Zhang, Wei, and Shou-Jiang Gao. 2012. "Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus" Pathogens 1, no. 2: 102-127. https://doi.org/10.3390/pathogens1020102

APA Style

Zhang, W., & Gao, S.-J. (2012). Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus. Pathogens, 1(2), 102-127. https://doi.org/10.3390/pathogens1020102

Article Metrics

Back to TopTop