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Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus

by Wei Zhang and Shou-Jiang Gao *
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA90033, USA
*
Author to whom correspondence should be addressed.
Current address: Department of Genetics, Yale School of Medicine, New Haven, CT06510, USA.
Pathogens 2012, 1(2), 102-127; https://doi.org/10.3390/pathogens1020102
Received: 2 September 2012 / Revised: 11 October 2012 / Accepted: 13 October 2012 / Published: 22 October 2012
(This article belongs to the Special Issue Infection and Cancer)
As obligate intracellular pathogens, viruses depend on the host cell machinery to complete their life cycle. Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus causally linked to the development of Kaposi’s sarcoma and several other lymphoproliferative malignancies. KSHV entry into cells is tightly regulated by diverse viral and cellular factors. In particular, KSHV actively engages cellular integrins and ubiquitination pathways for successful infection. Emerging evidence suggests that KSHV hijacks both actin and microtubule cytoskeletons at different phases during entry into cells. Here, we review recent findings on the early events during primary infection of KSHV and its closely related primate homolog rhesus rhadinovirus with highlights on the regulation of cellular cytoskeletons and signaling pathways that are important for this phase of virus life cycle. View Full-Text
Keywords: Kaposi’s Sarcoma-Associated Herpesvirus (KSHV); Rhesus Rhadinovirus (RRV); virus entry; endocytosis; actin; microtubule; integrin; cellular signaling; ubiquitination Kaposi’s Sarcoma-Associated Herpesvirus (KSHV); Rhesus Rhadinovirus (RRV); virus entry; endocytosis; actin; microtubule; integrin; cellular signaling; ubiquitination
MDPI and ACS Style

Zhang, W.; Gao, S.-J. Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus. Pathogens 2012, 1, 102-127.

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