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Open AccessCase Report

Adaptive, Iterative, Long-Term Personalized Therapy Management in a Case of Stage IV Refractory NSCLC

1
Avinash Cancer Clinic, Tilak Road, Pantancha Gate, Sadashiv Peth, Pune 411030, Maharashtra, India
2
Datar Cancer Genetics Ltd., F-8 D-Road, Ambad, Nasik 422010, Maharashtra, India
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2019, 9(3), 34; https://doi.org/10.3390/jpm9030034
Received: 19 June 2019 / Accepted: 3 July 2019 / Published: 5 July 2019
In this paper we report long-term therapy management based on iterative de novo molecular and cellular analysis in a case of metastatic non-small cell lung cancer (NSCLC), with prior history of treated colorectal cancer. In the described case temporal tumor evolution, emergent therapy resistance and disease recurrences were addressed via the administration of personalized label- and organ-agnostic treatments based on de novo tumor profiling. This adaptive and iterative treatment strategy countered disease progression at each instance and led to the durable regression of primary as well as metastatic lesions. Concurrently, serial evaluation of mutations in cell-free circulating tumor DNA (ctDNA) via liquid biopsy (LBx) was performed to monitor disease status, ascertain treatment response, identify emergent drug resistance and detect recurrence at sub-radiological levels. The treatment management strategy described herein effectively addressed multiple, sequential clinical conundrums for which viable options were unavailable under the current Standard of Care (SoC). View Full-Text
Keywords: non small cell lung cancer (NSCLC); precision oncology; personalized therapy management non small cell lung cancer (NSCLC); precision oncology; personalized therapy management
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Ranade, A.; Patil, D.; Bhatt, A.; Dhasare, R.; Datta, V.; Datar, R.; Akolkar, D. Adaptive, Iterative, Long-Term Personalized Therapy Management in a Case of Stage IV Refractory NSCLC. J. Pers. Med. 2019, 9, 34.

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