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Open AccessReview

Behavioral Symptoms after Breast Cancer Treatment: A Biobehavioral Approach

1
Department of Psychology, Rice University, Houston, TX 77005, USA
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Department of Symptoms Research, MD Anderson Cancer Center, Houston, TX 77030, USA
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Department of Psychiatry, Baylor College of Medicine, Houston, TX 77030, USA
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Department of Psychology, University of Houston, Houston, TX 77004, USA
5
Department of Science, Technology, Engineering, and Mathematics, Dillard University, New Orleans, LA 70122, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Jane M. Armer
J. Pers. Med. 2015, 5(3), 280-295; https://doi.org/10.3390/jpm5030280
Received: 7 April 2015 / Revised: 17 July 2015 / Accepted: 23 July 2015 / Published: 3 August 2015
(This article belongs to the Special Issue Long-term Cancer Survivorship)
Being diagnosed and treated for breast cancer is emotionally and physically challenging. Breast cancer is the most commonly diagnosed cancer and the second leading cause of death for women in the United States. Accordingly, women with a breast cancer history are the largest group of female cancer survivors. Psychological stress substantially augments adverse autonomic, endocrine, and immune discharge, including enhanced production of proinflammatory cytokines. Importantly, inflammation is a key biological mechanism underlying the symptom cluster of pain, depression, fatigue, and sleep disturbances; there is also good evidence that inflammation contributes to breast cancer recurrence. Stress may exert direct effects on psychological and physiological risk processes. In this review, we take a biobehavioral approach to understanding predictors and mechanisms underlying somatic symptoms in breast cancer survivors. View Full-Text
Keywords: breast cancer survivors; inflammation; SES; chronic stressors; proinflammatory cytokine production; recurrence; fatigue; depression breast cancer survivors; inflammation; SES; chronic stressors; proinflammatory cytokine production; recurrence; fatigue; depression
MDPI and ACS Style

Fagundes, C.; LeRoy, A.; Karuga, M. Behavioral Symptoms after Breast Cancer Treatment: A Biobehavioral Approach. J. Pers. Med. 2015, 5, 280-295.

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