A Curcumin-Based Oral Gel Has Potential Protective Efficacy against Oral Mucositis: In Vitro Study
Abstract
:1. Introduction
2. Material and Methods
2.1. Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS)
2.2. Cell Lines and Culture
2.3. Acid-Phosphatase Cytotoxicity Assay (APH) to Identify Suitable Concentrations of the Curcumin-Based Oral Gel
2.4. In Vitro Model of Oral Mucositis
2.5. Treatment of the H2O2-Induced Cells with the Curcumin-Based Oral Gel
2.6. Statistical Analyses
3. Results
3.1. Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS) Analysis Shows Constituents of the Curcumin-Based Oral Gel and Curcumin Quantity
3.2. Acid-Phosphatase Cytotoxicity Assay (APH)
3.3. Identifying the IC50 of H2O2 Concentrations for the In Vitro Oral Mucositis Model
3.4. Efficacy of the Curcumin-Based Oral Gel against Reactive Oxygen Species
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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No. | Molecular Weight | Name | Chemical Formula | Signal Intensity |
---|---|---|---|---|
1 | 68.99715 | 1,2,4-Triazole | C2H3N3 | 11.74 |
2 | 104.99229 | Diethanolamine | C4H11NO2 | 7.97 |
3 | 119.04913 | Calcium monoselenide | CaSe | 2.14 |
4 | 151.07532 | Trifluoromethanesulfonic acid | CF3SO3H | 187.44 |
5 | 161.05968 | Alpha-aminoadipic acid | C6H11NO4 | 243023 |
6 | 177.05455 | Cinnamyl carbonate | C10H9O3 | 1065.95 |
7 | 178.05789 | 4-Chlorobenzylamine hydrochloride | C7H9Cl2N | 72.96 |
8 | 203.07018 | 2,7-Dichloro-1,2,3,8a-tetrahydroquinazoline | C8H8Cl2N2 | 21.21 |
9 | 219.06503 | 2-(2,6-Dichlorophenyl)acetohydrazide | C8H8Cl2N2O | 52.48 |
10 | 253.08578 | Diethyl 2-bromobutanedioate | C8H13BrO4 | 191.41 |
11 | 259.09644 | Methyl 4-(bromomethyl)-2-methoxybenzoate | C10H11BrO3 | 24.86 |
12 | 285.11197 | 1-(Bromomethyl)-4-[(difluoromethyl)sulfonyl]benzene | C8H7BrF2O2S | 473.38 |
13 | 286.11548 | 4-Bromo-5,7-difluoro-2-propylquinoline | C12H10BrF2N | 60.08 |
14 | 299.12814 | 5-Amino-3-chloro-2-octoxybenzoic acid | C15H22ClNO3 | 10.05 |
15 | 319.09662 | Norfloxacin | C16H18FN3O3 | 6.83 |
16 | 340.47421 | Behenic acid | C22H44O2 | 2.16 |
17 | 369.13248 | Dextromethorphan | C18H25NO | 14.36 |
18 | 386.29041 | 1-O-Sinapoyl-beta-D-glucose | C17H22O10 | 2.09 |
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Idrees, M.; Kujan, O. A Curcumin-Based Oral Gel Has Potential Protective Efficacy against Oral Mucositis: In Vitro Study. J. Pers. Med. 2024, 14, 1. https://doi.org/10.3390/jpm14010001
Idrees M, Kujan O. A Curcumin-Based Oral Gel Has Potential Protective Efficacy against Oral Mucositis: In Vitro Study. Journal of Personalized Medicine. 2024; 14(1):1. https://doi.org/10.3390/jpm14010001
Chicago/Turabian StyleIdrees, Majdy, and Omar Kujan. 2024. "A Curcumin-Based Oral Gel Has Potential Protective Efficacy against Oral Mucositis: In Vitro Study" Journal of Personalized Medicine 14, no. 1: 1. https://doi.org/10.3390/jpm14010001