Perspectives of Italian Physicians and Patients in the Treatment of Otitis Externa: A Real-Life Study
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Acute Otitis Externa (Swimmer’s Ear). Am. Fam. Physician 2023, 107, Online.
- Medina-Blasini, Y.; Sharman, T. Otitis Externa. In StatPearls; StatPearls Publishing: Tampa, FL, USA, 2023. [Google Scholar]
- Hajioff, D.; MacKeith, S. Otitis externa. BMJ Clin. Evid. 2015, 2015, 510. [Google Scholar]
- Rosenfeld, R.M.; Schwartz, S.R.; Cannon, C.R.; Roland, P.S.; Simon, G.R.; Kumar, K.A.; Huang, W.W.; Haskell, H.W.; Robertson, P.J. Clinical practice guideline: Acute otitis externa. Otolaryngol. Head Neck Surg. 2014, 150, S1–S24. [Google Scholar] [CrossRef] [PubMed]
- Kim, S.K.; Han, S.J.; Hong, S.J.; Hong, S.M. Microbiome of Acute Otitis Externa. J. Clin. Med. 2022, 11, 7074. [Google Scholar] [CrossRef] [PubMed]
- Luthra, H.; Sharma, V.; Jindal, N. Microbiological Profile and Antibiotic Sensitivity of 100 Cases of Otitis Externa. Indian J. Otolaryngol. Head Neck Surg. 2022, 74, 3616–3619. [Google Scholar] [CrossRef]
- Lee, J.S.; Lee, S.M.; Son, H.S.; Na Yoon, Y.; Shin, J.E.; Sul, W.J.; Yu, D.A.; Choe, Y.B.; Lee, Y.W. Analysis of the Microbiome of the Ear Canal in Normal Individuals and Patients with Chronic Otitis Externa. Ann. Dermatol. 2022, 34, 461–471. [Google Scholar] [CrossRef]
- Rasheed, A.M.; Hilal, S.A.; Abbas, A.M. Is adding an oral antibiotic with the topical antibiotic steroid useful in treatment of uncomplicated acute otitis externa in immunocompetent patients? J. Popul. Ther. Clin. Pharmacol. 2022, 29, e27–e32. [Google Scholar]
- Ugazio, E.; Tullio, V.; Binello, A.; Tagliapietra, S.; Dosio, F. Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques. Mol. Basel Switz. 2020, 25, 334. [Google Scholar] [CrossRef]
- Jackson, E.A.; Geer, K. Acute Otitis Externa: Rapid Evidence Review. Am. Fam. Physician 2023, 107, 145–151. [Google Scholar]
- Chu, L.; Acosta, A.M.; Aazami, H.; Dennis, P.; De Valle, O.; Ehmer, D.; Hedrick, J.A.; Ansley, J.F. Efficacy and Safety of Ciprofloxacin Plus Fluocinolone Acetonide Among Patients with Acute Otitis Externa: A Randomized Clinical Trial. JAMA Netw. Open 2022, 5, e2221699. [Google Scholar] [CrossRef]
- Ansley, J.; Mair, E.A.; Namini, H.; Lu, C.H.; LeBel, C. OTO-201 for the Treatment of Acute Otitis Externa: Results from a Phase 3 Randomized Clinical Study. Ann. Otol. Rhinol. Laryngol. 2019, 128, 524–533. [Google Scholar] [CrossRef]
- Lorente, J.; Sabater, F.; Rivas, M.P.; Fuste, J.; Risco, J.; Gómez, M. Ciprofloxacin plus fluocinolone acetonide versus ciprofloxacin alone in the treatment of diffuse otitis externa. J. Laryngol. Otol. 2014, 128, 591–598. [Google Scholar] [CrossRef]
- Panahi, Y.; Akhavan, A.; Sahebkar, A.; Hosseini, S.M.; Taghizadeh, M.; Akbari, H.; Sharif, M.R.; Imani, S. Investigation of the effectiveness of Syzygium aromaticum, Lavandula angustifolia and Geranium robertianum essential oils in the treatment of acute external otitis: A comparative trial with ciprofloxacin. J. Microbiol. Immunol. Infect. 2014, 47, 211–216. [Google Scholar] [CrossRef]
- Mostafa, M.G.; Ahmed, S.; Islam, M.R.; Rahman, M.A.; Khan, L.; Alam, M.M.; Ahmed, M.B. Efficacy of Clotrimazole 1% Solution Compared to Econazole Nitrate 1% + Triamcinolone Acetonide 0.1% Cream in Patient with Otomycosis. Mymensingh Med. J. MMJ 2021, 30, 638–643. [Google Scholar]
- Koltsidopoulos, P.; Skoulakis, C. Otomycosis with Tympanic Membrane Perforation: A Review of the Literature. Ear. Nose. Throat J. 2020, 99, 518–521. [Google Scholar] [CrossRef]
- Bance, M.; Rutka, J.A. Topical treatment for otorrhea: Issues and controversies. J. Otolaryngol. 2005, 34, S52–S55. [Google Scholar]
- Dirain, C.O.; Antonelli, P.J. Cytotoxicity of Tetracyclines in Human Tympanic Membrane Fibroblasts. Otol. Neurotol. 2023, 44, 520–524. [Google Scholar] [CrossRef]
- Jinn, T.H.; Kim, P.D.; Russell, P.T.; Church, C.A.; John, E.O.; Jung, T.T.K. Determination of ototoxicity of common otic drops using isolated cochlear outer hair cells. Laryngoscope 2001, 111, 2105–2108. [Google Scholar] [CrossRef]
- Burton, M.; Krumbeck, J.A.; Wu, G.; Tang, S.; Prem, A.; Gupta, A.K.; Dawson Jr, T.L. The adult microbiome of healthy and otitis patients: Definition of the core healthy and diseased ear microbiomes. PLoS ONE 2022, 17, e0262806. [Google Scholar] [CrossRef]
- Villedieu, A.; Papesh, E.; Weinberg, S.E.; Teare, L.; Radhakrishnan, J.; Elamin, W.F. Seasonal variation of Pseudomonas aeruginosa in culture positive otitis externa in South East England. Epidemiol. Infect. 2018, 146, 1811–1812. [Google Scholar] [CrossRef]
- Fusconi, M.; Petrozza, V.; Taddei, A.R.; Vinciguerra, V.; De Virgilio, A.; Chiarini, F.; Cirenza, M.; Gallinell, C.; Conte, M.; De Vincentiis, M. Is biofilm the cause of chronic otitis externa? Laryngoscope 2011, 121, 2626–2633. [Google Scholar] [CrossRef] [PubMed]
- Bruins, M.J.; Wijshake, D.; de Vries-van Rossum, S.V.; Klein Overmeen, R.G.J.; Ruijs, G.J.H.M. Otitis externa following aural irrigation linked to instruments contaminated with Pseudomonas aeruginosa. J. Hosp. Infect. 2013, 84, 222–226. [Google Scholar] [CrossRef] [PubMed]
- Hajjartabar, M. Poor-quality water in swimming pools associated with a substantial risk of otitis externa due to Pseudomonas aeruginosa. Water Sci. Technol. 2004, 50, 63–67. [Google Scholar] [CrossRef] [PubMed]
- Zhou, K.; Tian, K.-Y.; Liu, X.-Q.; Liu, W.; Zhang, X.-Y.; Liu, J.-Y.; Sun, F. Characteristic and Otopathogenic Analysis of a Vibrio alginolyticus Strain Responsible for Chronic Otitis Externa in China. Front. Microbiol. 2021, 12, 750642. [Google Scholar] [CrossRef] [PubMed]
- Kim, J.K.; Cho, J.H. Change of external auditory canal pH in acute otitis externa. Ann. Otol. Rhinol. Laryngol. 2009, 118, 769–772. [Google Scholar] [CrossRef] [PubMed]
- Nussinovitch, M.; Rimon, A.; Volovitz, B.; Raveh, E.; Prais, D.; Amir, J. Cotton-tip applicators as a leading cause of otitis externa. Int. J. Pediatr. Otorhinolaryngol. 2004, 68, 433–435. [Google Scholar] [CrossRef]
- Yang, T.-H.; Xirasagar, S.; Cheng, Y.-F.; Wu, C.-S.; Kao, Y.-W.; Shia, B.-C.; Lin, H.-C. Malignant Otitis Externa is Associated with Diabetes: A Population-Based Case-Control Study. Ann. Otol. Rhinol. Laryngol. 2020, 129, 585–590. [Google Scholar] [CrossRef]
- Tsilivigkos, C.; Avramidis, K.; Ferekidis, E.; Doupis, J. Malignant External Otitis: What the Diabetes Specialist Should Know-A Narrative Review. Diabetes Ther. 2023, 14, 629–638. [Google Scholar] [CrossRef]
- Durojaiye, O.C.; Slucka, A.; Kritsotakis, E.I. Retrospective analysis of outcomes of outpatient parenteral antimicrobial therapy (OPAT) for necrotising otitis externa. Eur. J. Clin. Microbiol. Infect. Dis. 2022, 41, 941–949. [Google Scholar] [CrossRef]
- Kraus, D.H.; Rehm, S.J.; Kinney, S.E. The evolving treatment of necrotizing external otitis. Laryngoscope 1988, 98, 934–939. [Google Scholar] [CrossRef]
- Forozidou, E.; Poutoglidis, A.; Tsetsos, N.; Kilmpasanis, A.; Fyrmpas, G. Surgery as a Last Resort for Persistent Auricular Perichondritis. Ear Nose Throat J. 2021, 10, 1455613211038343. [Google Scholar] [CrossRef]
- Treviño González, J.L.; Reyes Suárez, L.L.; Hernández de León, J.E. Malignant otitis externa: An updated review. Am. J. Otolaryngol. 2021, 42, 102894. [Google Scholar] [CrossRef]
- Tognetto, D.; Pastore, M.R.; Guerin, G.M.; Decorti, G.; Franzin, M.; Lagatolla, C.; Cirigliano, G. Bactericidal activity of three different antiseptic ophthalmic preparations as surgical prophylaxis. Graefes Arch. Clin. Exp. Ophthalmol. 2022, 260, 289–293. [Google Scholar] [CrossRef]
- Cagini, C.; Mariniello, M.; Messina, M.; Muzi, A.; Balducci, C.; Moretti, A.; Levorato, L.; Mencacci, A. The role of ozonized oil and a combination of tobramycin/dexamethasone eye drops in the treatment of viral conjunctivitis: A randomized clinical trial. Int. Ophthalmol. 2020, 40, 3209–3215. [Google Scholar] [CrossRef]
- Zerillo, L.; Polvere, I.; Varricchio, R.; Madera, J.R.; D’andrea, S.; Voccola, S.; Franchini, I.; Stilo, R.; Vito, P.; Zotti, T. Antibiofilm and repair activity of ozonated oil in liposome. Microb. Biotechnol. 2022, 15, 1422–1433. [Google Scholar] [CrossRef]
- Rizzo, S.; Savastano, M.C.; Bortolotti, D.; Savastano, A.; Gambini, G.; Caccuri, F.; Gentili, V.; Rizzo, R. COVID-19 Ocular Prophylaxis: The Potential Role of Ozonated-Oils in Liposome Eyedrop Gel. Transl. Vis. Sci. Technol. 2021, 10, 7. [Google Scholar] [CrossRef]
Male | Female | |
---|---|---|
Sex, number (%) | 2186 (52.9) | 1948 (47.1) |
Age, years (DS) | 45.9 ± 20.8 | 43.8 ± 20.1 |
Weight, Kg (DS) | 74.3 ± 15.4 | 62.7 ± 14.7 |
Height, cm (DS) | 170.7 ± 14.2 | 162.3 ± 12.7 |
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Gelardi, M.; Giancaspro, R.; Landi, M.; Santoiemma, L.; Balestra, M.; Cassano, M.; Rizzo, R. Perspectives of Italian Physicians and Patients in the Treatment of Otitis Externa: A Real-Life Study. J. Pers. Med. 2023, 13, 1083. https://doi.org/10.3390/jpm13071083
Gelardi M, Giancaspro R, Landi M, Santoiemma L, Balestra M, Cassano M, Rizzo R. Perspectives of Italian Physicians and Patients in the Treatment of Otitis Externa: A Real-Life Study. Journal of Personalized Medicine. 2023; 13(7):1083. https://doi.org/10.3390/jpm13071083
Chicago/Turabian StyleGelardi, Matteo, Rossana Giancaspro, Massimo Landi, Luigi Santoiemma, Maddalena Balestra, Michele Cassano, and Roberta Rizzo. 2023. "Perspectives of Italian Physicians and Patients in the Treatment of Otitis Externa: A Real-Life Study" Journal of Personalized Medicine 13, no. 7: 1083. https://doi.org/10.3390/jpm13071083
APA StyleGelardi, M., Giancaspro, R., Landi, M., Santoiemma, L., Balestra, M., Cassano, M., & Rizzo, R. (2023). Perspectives of Italian Physicians and Patients in the Treatment of Otitis Externa: A Real-Life Study. Journal of Personalized Medicine, 13(7), 1083. https://doi.org/10.3390/jpm13071083