Maturity-Onset Diabetes of the Young: Mutations, Physiological Consequences, and Treatment Options

Round 1

Reviewer 1 Report

This is a well written article with a thorough literature review. The authors have presented this article in an organized manner, providing detailed information on MODY and their genetic implications. I think it should be published as it brings readers up to date on this current topic and lays the groundwork for future clinical considerations for clinicians when making diagnoses.

Minor comment: 

1. Page 5, Lines 168-169: Please add a reference “Renal abnormalities 168 occur in 40% of MODY5 patients.”

Author Response

Review 1

All reviewers’ comments were left in their original form in black text while our responses can be found in blue text.

This is a well written article with a thorough literature review. The authors have presented this article in an organized manner, providing detailed information on MODY and their genetic implications. I think it should be published as it brings readers up to date on this current topic and lays the groundwork for future clinical considerations for clinicians when making diagnoses.

Minor comment: 

1. Page 5, Lines 168-169: Please add a reference “Renal abnormalities 168 occur in 40% of MODY5 patients.”

Response: We added a reference.

“Mutation in HNF-1β gene can result in severe non-diabetic renal disease, glomerulocystic kidney disease and hyperglycemia (Table 1) [45-51].”

Reviewer 2 Report

The review is good designed. The subject of MODY has been handled well and it has been a very descriptive article. Overall, I think it's an informative article. While reading, I updated my knowledge and learned new things.

Author Response

The review is good designed. The subject of MODY has been handled well and it has been a very descriptive article. Overall, I think it's an informative article. While reading, I updated my knowledge and learned new things.

Response: We appreciate for your comments.