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iPSCs and Exosomes: Partners in Crime Fighting Cardiovascular Diseases

by 1,2,* and 1,2,3,*
1
Laboratory Animal Science Unit, Leibniz-Institut für Primatenforschung, Deutsches Primatenzentrum GmbH, Kellnerweg 4, 37077 Göttingen, Germany
2
DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, 37077 Göttingen, Germany
3
Stiftung Tierärztliche Hochschule Hannover, University of Veterinary Medicine, 30559 Hannover, Germany
*
Authors to whom correspondence should be addressed.
Academic Editor: Robert Passier
J. Pers. Med. 2021, 11(6), 529; https://doi.org/10.3390/jpm11060529
Received: 4 May 2021 / Revised: 31 May 2021 / Accepted: 7 June 2021 / Published: 9 June 2021
Cardiovascular diseases are the leading cause of mortality worldwide. Understanding the mechanisms at the basis of these diseases is necessary in order to generate therapeutic approaches. Recently, cardiac tissue engineering and induced pluripotent stem cell (iPSC) reprogramming has led to a skyrocketing number of publications describing cardiovascular regeneration as a promising option for cardiovascular disease treatment. Generation of artificial tissue and organoids derived from induced pluripotent stem cells is in the pipeline for regenerative medicine. The present review summarizes the multiple approaches of heart regeneration with a special focus on iPSC application. In particular, we describe the strength of iPSCs as a tool to study the molecular mechanisms driving cardiovascular pathologies, as well as their potential in drug discovery. Moreover, we will describe some insights into novel discoveries of how stem-cell-secreted biomolecules, such as exosomes, could affect cardiac regeneration, and how the fine tuning of the immune system could be a revolutionary tool in the modulation of heart regeneration. View Full-Text
Keywords: heart failure; cardiovascular diseases; iPSCs cardiomyocyte; platforms; cardiopatches; exosomes; innate immunity; 2D and 3D models heart failure; cardiovascular diseases; iPSCs cardiomyocyte; platforms; cardiopatches; exosomes; innate immunity; 2D and 3D models
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MDPI and ACS Style

Germena, G.; Hinkel, R. iPSCs and Exosomes: Partners in Crime Fighting Cardiovascular Diseases. J. Pers. Med. 2021, 11, 529. https://doi.org/10.3390/jpm11060529

AMA Style

Germena G, Hinkel R. iPSCs and Exosomes: Partners in Crime Fighting Cardiovascular Diseases. Journal of Personalized Medicine. 2021; 11(6):529. https://doi.org/10.3390/jpm11060529

Chicago/Turabian Style

Germena, Giulia, and Rabea Hinkel. 2021. "iPSCs and Exosomes: Partners in Crime Fighting Cardiovascular Diseases" Journal of Personalized Medicine 11, no. 6: 529. https://doi.org/10.3390/jpm11060529

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