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Article

Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma

1
Department of Clinical Immunology, Pulmonology and Rheumatology, University Hospital Centre “Sestre Milosrdnice”, 10000 Zagreb, Croatia
2
Clinic for Lung Diseases Jordanovac, University Hospital Centre Zagreb, 10000 Zagreb, Croatia
3
School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
4
Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia
5
Croatian Institute of Transfusion Medicine, 10000 Zagreb, Croatia
6
Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2020, 10(4), 189; https://doi.org/10.3390/jpm10040189
Received: 18 September 2020 / Revised: 18 October 2020 / Accepted: 22 October 2020 / Published: 24 October 2020
Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B (TrkB) receptor might contribute to normal lung functioning and immune responses; however, their role in asthma remains unclear. Plasma BDNF concentrations, as well as BDNF and NTRK2 (TrkB gene) polymorphisms, were investigated in 120 asthma patients and 120 healthy individuals using enzyme-linked immunosorbent assay and polymerase chain reaction, respectively. The genotype and allele frequencies of BDNF Val66Met (rs6265) and NTRK2 rs1439050 polymorphisms did not differ between healthy individuals and asthma patients, nor between patients grouped according to severity or different asthma phenotypes. Although plasma BDNF concentrations were higher among healthy subjects carrying the BDNF Val66Met GG genotype compared to the A allele carriers, such differences were not detected in asthma patients, suggesting the influences of other factors. Plasma BDNF concentration was not affected by NTRK2 rs1439050 polymorphism. Asthma patients had higher plasma BDNF concentrations than control subjects; however, no differences were found between patients subdivided according to asthma severity, or Type-2, allergic, and eosinophilic asthma. Higher plasma BDNF levels were observed in asthma patients with aspirin sensitivity and aspirin-exacerbated respiratory disease. These results suggest that plasma BDNF may serve as a potential peripheral biomarker for asthma, particularly asthma with aspirin sensitivity. View Full-Text
Keywords: asthma; plasma BDNF concentration; BDNF and NTRK2 (TrkB gene) polymorphisms; severity; phenotypes; aspirin asthma; plasma BDNF concentration; BDNF and NTRK2 (TrkB gene) polymorphisms; severity; phenotypes; aspirin
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MDPI and ACS Style

Sreter, K.B.; Popovic-Grle, S.; Lampalo, M.; Konjevod, M.; Tudor, L.; Nikolac Perkovic, M.; Jukic, I.; Bingulac-Popovic, J.; Safic Stanic, H.; Markeljevic, J.; Pivac, N.; Svob Strac, D. Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma. J. Pers. Med. 2020, 10, 189. https://doi.org/10.3390/jpm10040189

AMA Style

Sreter KB, Popovic-Grle S, Lampalo M, Konjevod M, Tudor L, Nikolac Perkovic M, Jukic I, Bingulac-Popovic J, Safic Stanic H, Markeljevic J, Pivac N, Svob Strac D. Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma. Journal of Personalized Medicine. 2020; 10(4):189. https://doi.org/10.3390/jpm10040189

Chicago/Turabian Style

Sreter, Katherina B., Sanja Popovic-Grle, Marina Lampalo, Marcela Konjevod, Lucija Tudor, Matea Nikolac Perkovic, Irena Jukic, Jasna Bingulac-Popovic, Hana Safic Stanic, Jasenka Markeljevic, Nela Pivac, and Dubravka Svob Strac. 2020. "Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma" Journal of Personalized Medicine 10, no. 4: 189. https://doi.org/10.3390/jpm10040189

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