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Open AccessArticle

Experimental Biointegration of a Titanium Implant in Delayed Mandibular Reconstruction

1
Department of General and Pediatric Dentistry, Stavropol State Medical University, 310 Mira str., Stavropol 355017, Russia
2
Department of Oncology and Reconstructive Surgery, Sechenov University, Ministry of Health of Russia, Bolshaya Pirogovskaya, 6/1, Moscow 119431, Russia
3
Institute for Regenerative Medicine, Sechenov University, Ministry of Health of Russia, Bolshaya Pirogovskaya, 6/1, Moscow 119431, Russia
4
Department of Oncology and Plastic Surgery, Institute for Advanced Studies of the Federal Medical-Biological Agency, Volokolamskoye Shosse, 30, Moscow 123182, Russia
5
Joint Stock Engineering Company Atomstroyexport JSC “Science and Innovations”, Kadashevskaya Naberegnaya, 32/2, Moscow 115035, Russia
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2020, 10(1), 6; https://doi.org/10.3390/jpm10010006
Received: 4 January 2020 / Revised: 20 January 2020 / Accepted: 28 January 2020 / Published: 3 February 2020
(This article belongs to the Special Issue Molecular Diagnosis and New Therapeutic Approach of Oral Diseases)
Background: Mandibular reconstruction, after extensive resection of the mandible for the treatment of oral cancer, is a well-known procedure, however, relatively little is known about bone integration into the titanium implant after reconstruction with a temporary plastic implant. The main goal of this experimental study was to study the process of osseous integration into the titanium implant in an in vivo experiment following prior mandibular reconstruction with a temporary plastic implant. Materials and Methods: Four ewes initially underwent a partial one-sided resection of the mandible, with the formation of an approximately 3 × 1 cm defect. All of the subjects received reconstruction with an implantation of a plastic plate (3 cm). The plastic plate was removed and replaced by a titanium implant at 1, 3, 6, and 12 months, accordingly. Both plastic and titanium implants were made via 3D-printing technology and personalized modeling. A total of 6 months after titanium implantation, a histological evaluation of biointegration was performed. Results: All surgeries were uncomplicated. The integration of osseous tissue into the titanium implant was seen in all cases. Histologically, each case showed variable integration of dense fibrotic tissue with fibroblasts and non-mature bone tissue with a definitive layer of bone matrix with many osteoblasts on the periphery. The prior implantation of the plastic plate did not interfere with bone integration into the titanium implant. Conclusion: Preliminary results demonstrated that a temporary plastic implant for mandibular reconstruction does not interfere with the consequent osseous biointegration of a permanent titanium implant. This shows that temporary reconstruction is a safe solution when delayed mandibular reconstruction is required due to disease severity. View Full-Text
Keywords: mandibular reconstruction; personalized implants; 3D implant modeling; medical technologies mandibular reconstruction; personalized implants; 3D implant modeling; medical technologies
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Dolgolev, A.; Reshetov, I.; Svyatoslavov, D.; Sinelnikov, M.; Kudrin, K.; Dub, V.; Put, V.; Anikin, V. Experimental Biointegration of a Titanium Implant in Delayed Mandibular Reconstruction. J. Pers. Med. 2020, 10, 6.

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