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Salivary Diagnostics—Point-of-Care diagnostics of MMP-8 in dentistry and medicine

Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, 17177 Stockholm, Sweden
Division of Periodontology, Dentognostics GmbH, 07745 Jena, Germany
Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki University Central Hospital, 00014 Helsinki, Finland
Author to whom correspondence should be addressed.
Academic Editors: David Wong and Martin Weber
Diagnostics 2017, 7(1), 7;
Received: 26 September 2016 / Revised: 6 January 2017 / Accepted: 12 January 2017 / Published: 20 January 2017
(This article belongs to the Special Issue Oral Fluid-Based Molecular Diagnostics)
Human saliva is an easily accessible biological fluid and contains a variety of disease-related biomarkers, which makes it a potential diagnostic medium. The clinical use of salivary/oral fluid biomarkers to identify oral and systemic conditions requires the development of non-invasive screening and diagnostic technologies, and is among the main goals of oral fluid researchers. The analysis of the disease-specific oral and systemic biomarkers in saliva and oral fluids (i.e., mouth-rinse, gingival crevicular fluid (GCF) and peri-implantitis sulcular fluid (PISF)) is demanding. Several factors influence their expression and release; these factors include the intracellular location, the molecular size and the flow characteristics of the biological fluid. The type of saliva/oral fluid utilized for the diagnostics affects the analysis. High sensitivity together with sophisticated methods and techniques are essential to get a useful outcome. We describe here a recently developed mouth-rinse that is practical, convenient and inexpensive, as well as PISF chair-side/point of care (PoC) lateral-flow active matrix metalloproteinase (aMMP-8) immunoassays to detect, predict and monitor the course and treatment of periodontitis and peri-implantitis. View Full-Text
Keywords: diagnostic test; point-of-care; periodontitis; peri-implantitis; systemic diseases diagnostic test; point-of-care; periodontitis; peri-implantitis; systemic diseases
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Rathnayake, N.; Gieselmann, D.-R.; Heikkinen, A.M.; Tervahartiala, T.; Sorsa, T. Salivary Diagnostics—Point-of-Care diagnostics of MMP-8 in dentistry and medicine. Diagnostics 2017, 7, 7.

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