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Salivary Diagnostics—Point-of-Care diagnostics of MMP-8 in dentistry and medicine

1
Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, 17177 Stockholm, Sweden
2
Division of Periodontology, Dentognostics GmbH, 07745 Jena, Germany
3
Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki University Central Hospital, 00014 Helsinki, Finland
*
Author to whom correspondence should be addressed.
Academic Editors: David Wong and Martin Weber
Diagnostics 2017, 7(1), 7; https://doi.org/10.3390/diagnostics7010007
Received: 26 September 2016 / Revised: 6 January 2017 / Accepted: 12 January 2017 / Published: 20 January 2017
(This article belongs to the Special Issue Oral Fluid-Based Molecular Diagnostics)
Human saliva is an easily accessible biological fluid and contains a variety of disease-related biomarkers, which makes it a potential diagnostic medium. The clinical use of salivary/oral fluid biomarkers to identify oral and systemic conditions requires the development of non-invasive screening and diagnostic technologies, and is among the main goals of oral fluid researchers. The analysis of the disease-specific oral and systemic biomarkers in saliva and oral fluids (i.e., mouth-rinse, gingival crevicular fluid (GCF) and peri-implantitis sulcular fluid (PISF)) is demanding. Several factors influence their expression and release; these factors include the intracellular location, the molecular size and the flow characteristics of the biological fluid. The type of saliva/oral fluid utilized for the diagnostics affects the analysis. High sensitivity together with sophisticated methods and techniques are essential to get a useful outcome. We describe here a recently developed mouth-rinse that is practical, convenient and inexpensive, as well as PISF chair-side/point of care (PoC) lateral-flow active matrix metalloproteinase (aMMP-8) immunoassays to detect, predict and monitor the course and treatment of periodontitis and peri-implantitis. View Full-Text
Keywords: diagnostic test; point-of-care; periodontitis; peri-implantitis; systemic diseases diagnostic test; point-of-care; periodontitis; peri-implantitis; systemic diseases
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Rathnayake, N.; Gieselmann, D.-R.; Heikkinen, A.M.; Tervahartiala, T.; Sorsa, T. Salivary Diagnostics—Point-of-Care diagnostics of MMP-8 in dentistry and medicine. Diagnostics 2017, 7, 7.

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