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Article

Development of a Hybrid Nanoprobe for Triple-Modality MR/SPECT/Optical Fluorescence Imaging

1
Department of Medical Radiation Physics, Lund University, Barngatan 2, 221 85 Lund, Sweden
2
Department of Physics, Lund University, Professorsgatan 1, 223 63 Lund, Sweden
3
Department of Surgery, Skane University Hospital, Entrégatan 7, 221 85 Lund, Sweden
4
Lund University Bioimaging Center (LBIC), Kliniggatan 32, 222 42 Lund, Sweden
5
Department of Radiology, Skane University Hospital, Entrégatan 7, 221 85 Lund, Sweden
*
Author to whom correspondence should be addressed.
Diagnostics 2014, 4(1), 13-26; https://doi.org/10.3390/diagnostics4010013
Received: 29 January 2014 / Revised: 28 February 2014 / Accepted: 4 March 2014 / Published: 10 March 2014
(This article belongs to the Collection Hybrid Imaging in Medicine)
Hybrid clinical imaging is an emerging technology, which improves disease diagnosis by combining already existing technologies. With the combination of high-resolution morphological imaging, i.e., MRI/CT, and high-sensitive molecular detection offered by SPECT/PET/Optical, physicians can detect disease progression at an early stage and design patient-specific treatments. To fully exploit the possibilities of hybrid imaging a hybrid probe compatible with each imaging technology is required. Here, we present a hybrid nanoprobe for triple modality MR/SPECT/Fluorescence imaging. Our imaging agent is comprised of superparamagnetic iron oxide nanoparticles (SPIONs), labeled with 99mTc and an Alexa fluorophore (AF), together forming 99mTc-AF-SPIONs. The agent was stable in human serum, and, after subcutaneous injection in the hind paw of Wistar rats, showed to be highly specific by accumulating in the sentinel lymph node. All three modalities clearly visualized the imaging agent. Our results show that a single imaging agent can be used for hybrid imaging. The use of a single hybrid contrast agent permits simultaneous hybrid imaging and, more conventionally, allow for single modality imaging at different time points. For example, a hybrid contrast agent enables pre-operative planning, intra-operative guidance, and post-operative evaluation with the same contrast agent. View Full-Text
Keywords: SPION; SPECT; optical; fluorescence imaging; magnetic resonance imaging; MR; SLN SPION; SPECT; optical; fluorescence imaging; magnetic resonance imaging; MR; SLN
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MDPI and ACS Style

Madru, R.; Svenmarker, P.; Ingvar, C.; Ståhlberg, F.; Engels, S.-A.; Knutsson, L.; Strand, S.-E. Development of a Hybrid Nanoprobe for Triple-Modality MR/SPECT/Optical Fluorescence Imaging. Diagnostics 2014, 4, 13-26. https://doi.org/10.3390/diagnostics4010013

AMA Style

Madru R, Svenmarker P, Ingvar C, Ståhlberg F, Engels S-A, Knutsson L, Strand S-E. Development of a Hybrid Nanoprobe for Triple-Modality MR/SPECT/Optical Fluorescence Imaging. Diagnostics. 2014; 4(1):13-26. https://doi.org/10.3390/diagnostics4010013

Chicago/Turabian Style

Madru, Renata, Pontus Svenmarker, Christian Ingvar, Freddy Ståhlberg, Stefan-Andersson Engels, Linda Knutsson, and Sven-Erik Strand. 2014. "Development of a Hybrid Nanoprobe for Triple-Modality MR/SPECT/Optical Fluorescence Imaging" Diagnostics 4, no. 1: 13-26. https://doi.org/10.3390/diagnostics4010013

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