Progressive Age-Associated Blood–Brain Barrier Leak/Dysfunction-Nexus of Neurodegenerative Disease Using MRI Markers to Identify Preclinical Disease and Potential New Targets for Future Treatments
Abstract
:1. Introduction
1.1. Normal BBB Physiology and Regulation
1.2. Blood–Brain Barrier Cellular Makeup and Their Function
1.3. Capillary Endothelial Cells
1.4. Pericytes
1.5. Tight Junctions
1.6. Astrocytes
1.7. Microglia
1.8. BBB Dysfunction
2. Altered Fluid Dynamic
3. Early Identification of BBB Dysfunction
4. Current Methods of Risk Reduction
5. Conclusions—Where Do We Go from Here?
Funding
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Joseph, C.R. Progressive Age-Associated Blood–Brain Barrier Leak/Dysfunction-Nexus of Neurodegenerative Disease Using MRI Markers to Identify Preclinical Disease and Potential New Targets for Future Treatments. Diagnostics 2024, 14, 726. https://doi.org/10.3390/diagnostics14070726
Joseph CR. Progressive Age-Associated Blood–Brain Barrier Leak/Dysfunction-Nexus of Neurodegenerative Disease Using MRI Markers to Identify Preclinical Disease and Potential New Targets for Future Treatments. Diagnostics. 2024; 14(7):726. https://doi.org/10.3390/diagnostics14070726
Chicago/Turabian StyleJoseph, Charles R. 2024. "Progressive Age-Associated Blood–Brain Barrier Leak/Dysfunction-Nexus of Neurodegenerative Disease Using MRI Markers to Identify Preclinical Disease and Potential New Targets for Future Treatments" Diagnostics 14, no. 7: 726. https://doi.org/10.3390/diagnostics14070726