Diagnostic and Prognostic Value of Thrombocytopenia in Severe Burn Injuries
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variables | Classification | Cases | Proportion (%) |
---|---|---|---|
Sex | Female | 30 | 33.3% |
Male | 60 | 66.7% | |
Age | ≤40 | 23 | 25.5% |
41–60 | 25 | 27.8% | |
61–80 | 31 | 34.4% | |
>80 | 11 | 12.2% | |
Mechanism of injury | Flame | 77 | 85.5% |
Scalds | 8 | 8.9% | |
Electrical burns | 4 | 4.4% | |
Contact burns | 1 | 1.1% | |
Burn setting | Domestic accident | 71 | 78.9% |
Work accident | 3 | 3.3% | |
Self-harm | 12 | 13.3% | |
Burning aggression | 2 | 2.2% | |
Undetermined | 2 | 2.2% | |
TBSA | 20–40 | 48 | 53.3% |
41–60 | 19 | 21.1% | |
61–80 | 16 | 17.8% | |
81–100% | 7 | 7.8% | |
3rd-degree burns | No | 22 | 24.4% |
Yes | 68 | 75.6% | |
Inhalation injuries | No | 26 | 28.9% |
Yes | 64 | 71.1% |
Thrombocytopenia—day 3/Survival (n = 88) | Survivors | Non-survivors | p * | ||
No. | Percent | No. | Percent | ||
Normal TPC | 18 | 56.30% | 11 | 19.60% | 0.001 |
Thrombocytopenia | 14 | 43.80% | 45 | 80.40% | |
Thrombocytopenia—day 7/Survival (n = 84) | Survivors | Non-survivors | p * | ||
No. | Percent | No. | Percent | ||
Normal TPC | 26 | 81.30% | 8 | 15.40% | <0.001 |
Thrombocytopenia | 6 | 18.80% | 44 | 84.60% | |
Thrombocytopenia—day 14/Survival (n = 65) | Survivors | Non-survivors | p * | ||
No. | Percent | No. | Percent | ||
Normal TPC | 31 | 100% | 13 | 38.20% | <0.001 |
Thrombocytopenia | 0 | 0% | 21 | 61.80% | |
Thrombocytopenia—day 21/Survival (n = 45) | Survivors | Non-survivors | p * | ||
No. | Percent | No. | Percent | ||
Normal TPC | 24 | 96% | 11 | 55% | 0.002 |
Thrombocytopenia | 1 | 4% | 9 | 45% | |
Thrombocytopenia—day 28/Survival (n = 36) | Survivors | Non-survivors | p * | ||
No. | Percent | No. | Percent | ||
Normal TPC | 19 | 95% | 10 | 62.50% | 0.03 |
Thrombocytopenia | 1 | 5% | 6 | 37.50% | |
Thrombocytopenia—day 45/Survival (n = 21) | Survivors | Non-survivors | p * | ||
No. | Percent | No. | Percent | ||
Normal TPC | 10 | 90.90% | 4 | 40% | 0.024 |
Thrombocytopenia | 1 | 9.10% | 6 | 60% | |
Thrombocytopenia—day 60/Survival (n = 13) | Survivors | Non-survivors | p * | ||
No. | Percent | No. | Percent | ||
Normal TPC | 7 | 100% | 2 | 33.30% | 0.021 |
Thrombocytopenia | 0 | 0% | 4 | 66.70% |
Thrombocytopenia—day 3 post-burn Absent Present | Mean (95% CI) | Median (IQR) | p * |
65.1 (46.3–83.9) | 63 (19–97) | 0.025 | |
39.4 (28.9–49.9) | 20 (10–60) | ||
Thrombocytopenia—day 7 post-burn Absent Present | Mean (95% CI) | Median (IQR) | p * |
80.1 (64.0–96.2) | 97 | <0.001 | |
30.1 (20.8–39.3) | 16 (9–39) | ||
Thrombocytopenia—day 14 post-burn Absent Present | Mean (95% CI) | Median (IQR) | p * |
75.9 (62.9–88.9) | 77 | <0.001 | |
27.1 (17.2–37.1) | 18 (16–26) | ||
Thrombocytopenia—day 21 post-burn Absent Present | Mean (95% CI) | Median (IQR) | p * |
83.9 (69.9–97.8) | 97 (63–113) | <0.001 | |
34.3 (24.4–44.2) | 27 (21–50) | ||
Thrombocytopenia—day 28 post-burn Absent Present | Mean (95% CI) | Median (IQR) | p * |
84.4 (69.8–99) | 97 (63–113) | <0.001 | |
42.2 (30.8–53.7) | 45 (27–60) |
Platelet count—day 3 Normal TPC (p = 0.400 **) Thrombocytopenia (p = 0.125 **) | Mean ± SD | Median (IQR) | p * (p = 0.365 ***) |
8.41 ± 1.84 | 8 (7–9.5) | <0.001 | |
10.81 ± 2.15 | 11 (9–12) | ||
Platelet count—day 7 Normal TPC (p = 0.288 **) Thrombocytopenia (p = 0.320 **) | Mean ± SD | Median (IQR) | p * (p = 0.197 ***) |
8.32 ± 1.59 | 8 (7–9) | <0.001 | |
10.98 ± 2.05 | 11 (10–12) | ||
Platelet count—day 14 Normal TPC (p = 0.155 **) Thrombocytopenia (p = 0.13 7 **) | Mean ± SD | Median (IQR) | p * (p = 0.805 ***) |
8.80 ± 1.72 | 9 (8–10) | <0.001 | |
10.67 ± 1.68 | 11 (9.5–12) |
Platelet count—day 3 post-burn | Mean ± SD | Median (IQR) | p * |
Normal range (p = 0.134 **) | 48.2 ± 16.7 | 44 (36–61.5) | 0.002 |
Thrombocytopenia (p = 0.006 **) | 61.1 ± 17.7 | 66 (44–76) | |
* Mann–Whitney U Test, ** Shapiro–Wilk Test | |||
Platelet count—day 7 post-burn | Mean ± SD | Median (IQR) | p * |
Normal range (p = 0.055 **) | 48.7 ± 17.8 | 44 (34.7–61.2) | 0.002 |
Thrombocytopenia (p = 0.039 **) | 61.7 ± 16.8 | 65 (47.7–76.2) | |
* Mann–Whitney U Test, ** Shapiro–Wilk Test | |||
Platelet count—day 14 post-burn | Mean ± SD | Median (IQR) | p * (p = 0.644 ***) |
Normal range (p = 0.077 **) | 52.4 ± 17.8 | 48.5 (38.5–69.5) | 0.015 |
Thrombocytopenia (p = 0.389 **) | 64 ± 16.9 | 64 (49–78.5) | |
* Student t-Test, ** Shapiro–Wilk Test, *** Levene’s Test for Equality of Variances | |||
Platelet count—day 21 post-burn | Mean ± SD | Median (IQR) | p * (p = 0.039 ***) |
Normal range (p = 0.090 **) | 53.1 ± 19 | 47 (38–71) | 0.056 |
Thrombocytopenia (p = 0.398 **) | 63.2 ± 12.1 | 62.5 (49.7–73.5) | |
* Welch t-Test, ** Shapiro–Wilk Test, *** Levene’s Test for Equality of Variances | |||
Platelet count—day 28 post-burn | Mean ± SD | Median (IQR) | p * |
Normal range (p = 0.155 **) | 54.1 ± 17.4 | 51 (40.5–71) | 0.036 |
Thrombocytopenia (p = 0.013 **) | 70.7 ± 18.8 | 76 (70–82) | |
* Mann–Whitney U Test, ** Shapiro–Wilk Test | |||
Platelet count—day 45 post-burn | Mean ± SD | Median (IQR) | p * (p = 0.306 ***) |
Normal range (p = 0.345 **) | 52.2 ± 18.1 | 49 (38.7–72.2) | 0.019 |
Thrombocytopenia (p = 0.503 **) | 72.1 ± 13.4 | 76 (59–82) | |
* Student t-Test, ** Shapiro–Wilk Test, *** Levene’s Test for Equality of Variances | |||
Platelet count—day 60 post-burn | Mean ± SD | Median (IQR) | p * |
Normal range (p = 0.073 **) | 51 ± 18.2 | 44 (37.5–73.5) | 0.020 |
Thrombocytopenia (p = 0.003 **) | 74 ± 15.3 | 81.5 (58.5–82) | |
* Mann–Whitney U Test, ** Shapiro–Wilk Test |
Thrombocytopenia—day 3 post-burn | Mean TBSA ± SD | Median TBSA (IQR) | p * |
Absent (p < 0.001 **) | 39.3 ± 15.4 | 35 (27.5–40) | 0.004 |
Present (p = 0.006 **) | 51.9 ± 19.7 | 50 (35–70) | |
Thrombocytopenia—day 7 post-burn | Mean TBSA ± SD | Median TBSA (IQR) | p * |
Absent (p = 0.004 **) | 38.3 ± 13.1 | 35 (25–42.5) | 0.001 |
Present (p = 0.011 **) | 52.6 ± 20 | 50 (35–70) |
TPC—day 3 | Without 3rd-degree burns | 3rd-degree burns | p * | No inhalation injury | Inhalation injury | p * |
Normal TPC | 12 patients (54.5%) | 17 patients (25.8%) | 0.019 | 12 patients (46.2%) | 17 patients (27.4%) | 0.135 |
Thrombocytopenia | 10 patients (45.5%) | 49 patients (74.2%) | 14 patients (53.8%) | 45 patients (72.6%) | ||
TPC—day 7 | Without 3rd-degree burns | 3rd-degree burns | p * | No inhalation injury | Inhalation injury | p * |
Normal TPC | 14 patients (63.6%) | 20 patients (32.3%) | 0.013 | 15 patients (60%) | 19 patients (32.2%) | 0.028 |
Thrombocytopenia | 8 patients (36.4%) | 42 patients (67.7%) | 10 patients (40%) | 40 patients (67.8%) |
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Bordeanu-Diaconescu, E.-M.; Grosu-Bularda, A.; Frunza, A.; Grama, S.; Andrei, M.-C.; Neagu, T.-P.; Lascar, I.; Hariga, C.-S. Diagnostic and Prognostic Value of Thrombocytopenia in Severe Burn Injuries. Diagnostics 2024, 14, 582. https://doi.org/10.3390/diagnostics14060582
Bordeanu-Diaconescu E-M, Grosu-Bularda A, Frunza A, Grama S, Andrei M-C, Neagu T-P, Lascar I, Hariga C-S. Diagnostic and Prognostic Value of Thrombocytopenia in Severe Burn Injuries. Diagnostics. 2024; 14(6):582. https://doi.org/10.3390/diagnostics14060582
Chicago/Turabian StyleBordeanu-Diaconescu, Eliza-Maria, Andreea Grosu-Bularda, Adrian Frunza, Sabina Grama, Mihaela-Cristina Andrei, Tiberiu-Paul Neagu, Ioan Lascar, and Cristian-Sorin Hariga. 2024. "Diagnostic and Prognostic Value of Thrombocytopenia in Severe Burn Injuries" Diagnostics 14, no. 6: 582. https://doi.org/10.3390/diagnostics14060582
APA StyleBordeanu-Diaconescu, E.-M., Grosu-Bularda, A., Frunza, A., Grama, S., Andrei, M.-C., Neagu, T.-P., Lascar, I., & Hariga, C.-S. (2024). Diagnostic and Prognostic Value of Thrombocytopenia in Severe Burn Injuries. Diagnostics, 14(6), 582. https://doi.org/10.3390/diagnostics14060582