Specific Binding Ratio Estimation of [123I]-FP-CIT SPECT Using Frontal Projection Image and Machine Learning
Abstract
:1. Introduction
2. Materials and Methods
2.1. SPECT Imaging
2.2. SBR Calculation
2.3. Network Architecture
2.4. Datasets
2.5. Evolution
2.6. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Catafau, A.M.; Tolosa, E.; DaTSCAN Clinically Uncertain Parkinsonian Syndromes Study Group. Impact of dopamine transporter SPECT using 123I-Ioflupane on diagnosis and management of patients with clinically uncertain Parkinsonian syndromes. Mov. Disord. 2004, 19, 1175–1182. [Google Scholar] [CrossRef] [PubMed]
- Walker, Z.; Jaros, E.; Walker, R.W.H.; Lee, L.; Costa, D.C.; Livingston, G.; Ince, P.G.; Perry, R.; Mckeith, I.; Katona, C.L.E. Dementia with Lewy bodies: A comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy. J. Neurol. Neurosurg. Psychiatry 2007, 78, 1176–1181. [Google Scholar] [CrossRef] [PubMed]
- McKeith, I.; O’Brien, J.; Walker, Z.; Tatsch, K.; Booij, J.; Darcourt, J.; Padovani, A.; Giubbini, R.; Bonuccelli, U.; Volterrani, D.; et al. Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: A phase III, multicentre study. Lancet Neurol. 2007, 6, 305–313. [Google Scholar] [CrossRef] [PubMed]
- Benamer, T.S.; Patterson, J.; Grosset, D.G.; Booij, J.; de Bruin, K.; van Royen, E.; Speelman, J.D.; Horstink, M.H.I.M.; Sips, H.J.W.A.; Dierckx, R.A.; et al. Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]FP-CIT SPECT imaging. Mov. Disord. 2000, 15, 503–510. [Google Scholar] [CrossRef] [PubMed]
- Badiavas, K.; Molyvda, E.; Iakovou, I.; Tsolaki, M.; Psarrakos, K.; Karatzas, N. SPECT imaging evaluation in movement disorders: Far beyond visual assessment. Eur. J. Nucl. Med. Mol. Imaging 2011, 38, 764–773. [Google Scholar] [CrossRef]
- Booij, J.; Habraken, J.B.; Bergmans, P.; Tissingh, G.; Winogrodzka, A.; Wolters, E.C.; Janssen, A.G.; Stoof, J.C.; van Royen, E.A. Imaging of dopamine transporters with iodine-123-FP-CIT SPECT in healthy controls and patients with Parkinson’s disease. J. Nucl. Med. 1998, 39, 1879–1884. [Google Scholar]
- Soderlund, T.A.; Dickson, J.C.; Prvulovich, E.; Ben-Haim, S.; Kemp, P.; Booij, J.; Nobili, F.; Thomsen, G.; Sabri, O.; Koulibaly, P.M.; et al. Value of semiquantitative analysis for clinical reporting of 123I-2-β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane SPECT studies. J. Nucl. Med. 2013, 54, 714–722. [Google Scholar] [CrossRef] [Green Version]
- Djang, D.S.; Janssen, M.J.; Bohnen, N.; Booij, J.; Henderson, T.A.; Herholz, K.; Minoshima, S.; Rowe, C.C.; Sabri, O.; Seibyl, J.; et al. SNM Practice Guideline for Dopamine Transporter Imaging with I-123-Ioflupane SPECT 1. 0. J. Nucl. Med. 2012, 53, 154–163. [Google Scholar] [CrossRef] [Green Version]
- Darcourt, J.; Booij, J.; Tatsch, K.; Varrone, A.; Vander Borght, T.; Kapucu, O.L.; Nagren, K.; Nobili, F.; Walker, Z.; Van Laere, K. EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version 2. Eur. J. Nucl. Med. Mol. Imaging 2010, 37, 443–450. [Google Scholar] [CrossRef]
- Kita, A.; Okazawa, H.; Sugimoto, K.; Kaido, R.; Kidoya, E.; Kimura, H. Acquisition count dependence of the specific binding ratio in 123I-FP-CIT SPECT. Ann. Nucl. Med. 2021, 62, 3028. [Google Scholar] [CrossRef]
- Kita, A.; Onoguchi, M.; Shibutani, T.; Horita, H.; Oku, Y.; Kashiwaya, S.; Isaka, M.; Saitou, M. Standardization of the specific binding ratio in [123I]FP-CIT SPECT: Study by striatum phantom. Nucl. Med. Commun. 2019, 40, 484–490. [Google Scholar] [CrossRef]
- Nakajima, K.; Saito, S.; Chen, Z.; Komatsu, J.; Maruyama, K.; Shirasaki, N.; Watanabe, S.; Inaki, A.; Ono, K.; Kinuya, S. Diagnosis of Parkinson syndrome and Lewy-body disease using 123I-ioflupane images and a model with image features based on machine learning. Ann. Nucl. Med. 2022, 36, 765–776. [Google Scholar] [CrossRef]
- Ogawa, K.; Harata, Y.; Ichihara, T.; Kubo, A.; Hashimoto, S.; Kashiwaya, S. A practical method for position-dependent Compton-scatter correction in single photon emission CT. IEEE Trans. Med. Imaging 1991, 10, 408–412. [Google Scholar] [CrossRef]
- Tossici-Bolt, L.; Hoffmann, S.M.; Kemp, P.M.; Mehta, R.L.; Fleming, J.S. Quantification of [123I]FP-CIT SPECT brain images: An accurate technique measurement of the specific binding ratio. Eur. J. Nucl. Med. Mol. Imaging 2006, 33, 1491–1499. [Google Scholar] [CrossRef]
- Rahman, M.G.M.; Islam, M.M.; Tsujikawa, T.; Kiyono, Y.; Okazawa, H. Count-based method for specific binding ratio calculation in [I-123]FP-CIT SPECT analysis. Ann. Nucl. Med. 2019, 33, 14–21. [Google Scholar] [CrossRef] [Green Version]
- Rahman, M.G.M.; Islam, M.M.; Tsujikawa, T.; Okazawa, H. A novel automatic approach for calculation of the specific binding ratio in [i-123]fp-citspect. Diagnostics 2020, 10, 289. [Google Scholar] [CrossRef]
- Iwabuchi, Y.; Nakahara, T.; Kameyama, M.; Yamada, Y.; Hashimoto, M.; Matsusaka, Y.; Osada, T.; Ito, D.; Tabuchi, H.; Jinzaki, M. Impact of a combination of quantitative indices representing uptake intensity, shape, and asymmetry in DAT SPECT using machine learning: Comparison of different volume of interest settings. EJNMMI Res. 2019, 9, 7. [Google Scholar] [CrossRef]
- Murakami, H.; Kimura, A.; Yasumoto, T.; Miki, A.; Yamamoto, K.; Ito, N.; Momma, Y.; Owan, Y.; Yano, S.; Ono, K. Usefulness differs between the visual assessment and specific binding ratio of 123i-ioflupane spect in assessing clinical symptoms of drug-naïve parkinson’s disease patients. Front. Aging Neurosci. 2018, 10, 412. [Google Scholar] [CrossRef]
- LeCun, Y.; Bottou, L.; Bengio, Y.; Haffner, P. Gradient-based learning applied to document recognition. Proc. IEEE 1998, 86, 2278–2324. [Google Scholar] [CrossRef] [Green Version]
- Krizhevsky, A.; Sutskever, I.; Hinton, E.G. ImageNet classification with deep convolutional neural networks. In Proceedings of the NIPS’12 25th International Conference on Neural Information Processing Systems, New York, NY, USA, 3 December 2012; Volume 1, pp. 1097–1105. [Google Scholar]
- Selvaraju, R.R.; Cogswell, M.; Das, A.; Vedantam, R.; Parikh, D.; Batra, D. Grad-cam: Visual explanations from deep networks via gradient-based localization. Int. J. Comput. Vis. 2020, 128, 336–359. [Google Scholar] [CrossRef] [Green Version]
- Kanda, Y. Investigation of the freely available easy-to-use software “EZR” for medical statistics. Bone Marrow Transpl. 2013, 48, 452–458. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Shigekiyo, T.; Arawaka, S. Laterality of specific binding ratios on DAT-SPECT for differential diagnosis of degenerative parkinsonian syndromes. Sci. Rep. 2020, 10, 15761. [Google Scholar] [CrossRef] [PubMed]
- Booij, J.; Busemann Sokole, E.; Stabin, M.G.; Janssen, A.G.; de Bruin, K.; van Royen, E.A. Human biodistribution and dosimetry of [123I]FP-CIT: A potent radioligand for imaging of dopamine transporters. Eur. J. Nucl. Med. 1998, 25, 24–30. [Google Scholar] [CrossRef] [PubMed]
- Szegedy, C.; Wei, L.; Yangqing, J.; Pierre, S.; Scott, R.; Scott, R.; Dragomir, A.; Dumitru, E.; Vincent, V.; Andrew, R. Going deeper with convolutions. In Proceedings of the 2015 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), Boston, MA, USA, 7–12 June 2015; pp. 1–9. [Google Scholar] [CrossRef] [Green Version]
- He, K.; Zhang, X.; Ren, S.; Sun, J. Deep residual learning for image recognition. In Proceedings of the 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), Las Vegas, NV, USA, 27–30 June 2015; pp. 770–778. [Google Scholar] [CrossRef] [Green Version]
Training | Validation | Test | |
---|---|---|---|
Number of cases | 260 | 80 | 80 |
Age (y, mean ± SD) | 72.2 ± 9.6 | 71.8 ± 10.3 | 72.4 ± 9.8 |
Men/women (N) | 137/123 | 49/31 | 44/36 |
LeNet | AlexNet | ||||||||
---|---|---|---|---|---|---|---|---|---|
Dataset | MAE | RMSE | Corr | Slope | MAE | RMSE | Corr | Slope | |
DaT View | 128FOV | 1.56 | 1.87 | 0.36 | 0.21 | 1.21 | 1.51 | 0.44 | 0.16 |
40FOV | 0.92 | 1.18 | 0.74 | 0.60 | 0.86 | 1.09 | 0.78 | 0.47 | |
40FOV_DA | 0.83 | 1.05 | 0.80 | 0.74 | 0.76 | 0.94 | 0.84 | 0.74 | |
40FOVhalf | 1.00 | 1.25 | 0.71 | 0.67 | 0.98 | 1.21 | 0.72 | 0 60 | |
40FOV_DAhalf | 0.94 | 1.20 | 0.74 | 0.73 | 0.95 | 1.18 | 0.73 | 0.61 | |
Count-based methods | 128FOV | 0.58 | 0.72 | 0.41 | 0.23 | 0.63 | 0.76 | 0.25 | 0.10 |
40FOV | 0.35 | 0.42 | 0.84 | 0.70 | 0.48 | 0.57 | 0.84 | 0.36 | |
40FOV_DA | 0.35 | 0.44 | 0.83 | 0.76 | 0.35 | 0.42 | 0.87 | 0.59 | |
40FOVhalf | 0.45 | 0.55 | 0.73 | 0.59 | 0.39 | 0.50 | 0.78 | 0.64 | |
40FOV_DAhalf | 0.40 | 0.49 | 0.80 | 0.71 | 0.40 | 0.50 | 0.77 | 0.62 |
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Kita, A.; Okazawa, H.; Sugimoto, K.; Kosaka, N.; Kidoya, E.; Tsujikawa, T. Specific Binding Ratio Estimation of [123I]-FP-CIT SPECT Using Frontal Projection Image and Machine Learning. Diagnostics 2023, 13, 1371. https://doi.org/10.3390/diagnostics13081371
Kita A, Okazawa H, Sugimoto K, Kosaka N, Kidoya E, Tsujikawa T. Specific Binding Ratio Estimation of [123I]-FP-CIT SPECT Using Frontal Projection Image and Machine Learning. Diagnostics. 2023; 13(8):1371. https://doi.org/10.3390/diagnostics13081371
Chicago/Turabian StyleKita, Akinobu, Hidehiko Okazawa, Katsuya Sugimoto, Nobuyuki Kosaka, Eiji Kidoya, and Tetsuya Tsujikawa. 2023. "Specific Binding Ratio Estimation of [123I]-FP-CIT SPECT Using Frontal Projection Image and Machine Learning" Diagnostics 13, no. 8: 1371. https://doi.org/10.3390/diagnostics13081371