Inner Retinal Thinning Comparison between Branch Retinal Artery Occlusion and Primary Open-Angle Glaucoma
Abstract
:1. Introduction
2. Methods
2.1. Inclusion Criteria
2.2. Exclusion Criteria
2.3. Spectralis GMPE
2.4. Data Collection
2.5. Statistical Analysis
3. Results
3.1. BRAO Cohort
3.2. POAG Cohort
3.3. Comparison between POAG and BRAO Cohort
4. Discussion
Study Limitations
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Mean Values ± SD | p Value | |||||
---|---|---|---|---|---|---|
BRAO | Control | POAG | BRAO vs. Control | POAG vs. Control | POAG vs. BRAO | |
All layers total | 265 ± 20 | 285 ± 25 | 273 ± 16 | 0.0016 | 0.1703 | 0.2024 |
mRNFL total | 32 ± 6.0 | 39 ± 6.3 | 29 ± 7.9 | 0.0005 | 0.0008 | 0.0927 |
GCL total | 24 ± 3.9 | 30 ± 5.0 | 27 ± 5.8 | 0.0006 | 0.0478 | 0.1234 |
IPL total | 23 ± 3.3 | 26 ± 4.9 | 25 ± 4.7 | 0.0027 | 0.2349 | 0.0067 |
INL total | 25 ± 3.0 | 31 ± 3.9 | 32 ± 3.2 | 0.0039 | 0.0424 | <0.0001 |
Mean Values ± SD | p Value | |||||
---|---|---|---|---|---|---|
BRAO | Control | POAG | BRAO vs. Control | POAG vs. Control | POAG vs. BRAO | |
All layers-Hemisphere asymmetry | 38 ± 18 | 5.6 ± 5.5 | 7.4 ± 6/0 | <0.0001 | 0.4817 | <0.0001 |
mRNFL-Hemisphere asymmetry | 15 ± 8.1 | 5.7 ± 3.2 | 5.3 ± 4.4 | 0.0005 | 0.4904 | <0.0001 |
GCL-Hemisphere asymmetry | 10 ± 4.1 | 1.8 ± 2.8 | 2.1 ± 1.6 | <0.0001 | 0.1177 | <0.0001 |
IPL-Hemisphere asymmetry | 5.3 ± 2.7 | 1.2 ± 0.91 | 1.3 ± 1.2 | 0.0004 | 0.9434 | <0.0001 |
INL-Hemisphere asymmetry | 9.9 ± 3.9 | 1.1 ± 1.8 | 0.75 ± 0.85 | <0.0001 | 0.8303 | <0.0001 |
Parameter | AUC | Test Accuracy | p Value |
---|---|---|---|
All layers Hemisphere difference | 0.9563 | a | <0.0001 |
mRNFL Hemisphere difference | 0.8844 | b | <0.0001 |
GCL Hemisphere difference | 0.9720 | a | <0.0001 |
IPL total | 0.7594 | b | 0.0082 |
IPL Hemisphere difference | 0.8953 | b | <0.0001 |
INL total | 0.9672 | a | <0.0001 |
INL Hemisphere difference | 0.9781 | a | <0.0001 |
NRR Thinning (G) | 0.9000 | a | <0.0001 |
RNFL Thinning at 3.50 mm (G) | 0.8188 | b | 0.0012 |
Mean Values ± SD | p Value | |||||
---|---|---|---|---|---|---|
BRAO | Control | POAG | BRAO vs. Control | POAG vs. Control | POAG vs. BRAO | |
BMO area | 1.9 ± 0.44 | 1.9 ± 0.48 | 2 ± 0.43 | 0.99 | 0.9686 | 0.8689 |
NRR Thinning (G) | 257 ± 45 | 281 ± 48 | 167 ± 52 | 0.006 | <0.0001 | <0.0001 |
RNFL Thinning at 3.50 mm (G) | 87 ± 14 | 95 ± 11 | 67 ± 17 | 0.0245 | <0.0001 | 0.0008 |
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De Salvo, G.; Oshallah, M.; Sepetis, A.E.; Borbara, R.; Oliverio, G.W.; Meduri, A.; Frisina, R.; Jacob, A. Inner Retinal Thinning Comparison between Branch Retinal Artery Occlusion and Primary Open-Angle Glaucoma. Diagnostics 2023, 13, 3428. https://doi.org/10.3390/diagnostics13223428
De Salvo G, Oshallah M, Sepetis AE, Borbara R, Oliverio GW, Meduri A, Frisina R, Jacob A. Inner Retinal Thinning Comparison between Branch Retinal Artery Occlusion and Primary Open-Angle Glaucoma. Diagnostics. 2023; 13(22):3428. https://doi.org/10.3390/diagnostics13223428
Chicago/Turabian StyleDe Salvo, Gabriella, Mohamed Oshallah, Anastasios E. Sepetis, Ramez Borbara, Giovanni William Oliverio, Alessandro Meduri, Rino Frisina, and Aby Jacob. 2023. "Inner Retinal Thinning Comparison between Branch Retinal Artery Occlusion and Primary Open-Angle Glaucoma" Diagnostics 13, no. 22: 3428. https://doi.org/10.3390/diagnostics13223428