Radiomic Features Are Predictive of Response in Rectal Cancer Undergoing Therapy
Abstract
:1. Introduction
2. Methods
2.1. Study Population
2.2. Pathological Case Selection and Classification
2.3. Imaging Acquisition
2.4. Imaging Analysis
2.5. Radiomic Workflow
2.6. Statistical Analysis
2.7. Compliance with Ethical Standards
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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N = 38 | |
---|---|
Males | 26 |
Females | 12 |
Median age at diagnosis (IQR) | 66.9 |
T2 * | 2 |
T3 * | 27 |
T4 * | 9 |
CRM positive | 20 |
EMVI positive | 9 |
Mucinous tumor | 6 |
Median follow-up [weeks (IQR)] |
N = 38 | |
---|---|
Good responders (group 1) | 13 |
| 1 |
| 0 |
| 2 |
| 10 |
| 1 |
Poor responders (group 2) | 25 |
| 6 |
| 0 |
| 18 |
| 7 |
MRI Phases | Selected Features | Level/Order |
---|---|---|
T2 baseline | Dependence Non Uniformity Normalized | Second-order |
Size Zone Non Uniformity Normalized | Second-order | |
Busyness | Second-Order | |
Sphericity | Shape | |
Large Dependence Emphasis | Second-order | |
T2 follow-up | Flatness | Shape |
Strenght | Shape | |
Size Zone Non Uniformity Normalized | Second-order | |
LongRunHighGrayLevelEmphasis | Second-order | |
ADC baseline | Difference Variance | Second-order |
Id | Second-order | |
Sphericity | Shape | |
Elongation | Shape | |
Surface volume Ratio | Shape | |
Flatness | Shape | |
Cluster Shade | Second-order | |
Joint Energy | Second-order | |
Minimun | First-order | |
Kurtosis | First-order | |
Size Zone Non Uniformity Normalized | Second-order | |
ADC follow up | Sphericity | Shape |
Elongation | Shape | |
Low Gray Level Run Emphasis | Second-order | |
Busyness | Second-order |
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Santini, D.; Danti, G.; Bicci, E.; Galluzzo, A.; Bettarini, S.; Busoni, S.; Innocenti, T.; Galli, A.; Miele, V. Radiomic Features Are Predictive of Response in Rectal Cancer Undergoing Therapy. Diagnostics 2023, 13, 2573. https://doi.org/10.3390/diagnostics13152573
Santini D, Danti G, Bicci E, Galluzzo A, Bettarini S, Busoni S, Innocenti T, Galli A, Miele V. Radiomic Features Are Predictive of Response in Rectal Cancer Undergoing Therapy. Diagnostics. 2023; 13(15):2573. https://doi.org/10.3390/diagnostics13152573
Chicago/Turabian StyleSantini, Diletta, Ginevra Danti, Eleonora Bicci, Antonio Galluzzo, Silvia Bettarini, Simone Busoni, Tommaso Innocenti, Andrea Galli, and Vittorio Miele. 2023. "Radiomic Features Are Predictive of Response in Rectal Cancer Undergoing Therapy" Diagnostics 13, no. 15: 2573. https://doi.org/10.3390/diagnostics13152573