Dual-Energy Computed Tomography for Evaluation of Breast Cancer Follow-Ups: Comparison of Virtual Monoenergetic Images and Iodine-Map
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Image Acquisition
2.3. Image Reconstruction and Analysis
2.4. Breast Density Measurement
3. Results
3.1. Experiment 1
3.2. Experiment 2
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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40 keV | 50 keV | 60 keV | 70 keV | 80 keV | 90 keV | 100 keV | 110 keV | 120 keV | 130 keV | 140 keV | p Value | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
T/B | 5.04 (3.23, 12.66) | 4.25 (3.00, 10.21) | 3.70 (2.76, 8.37) | 3.23 (2.54, 7.09) | 2.90 (2.33, 6.13) | 2.75 (2.15, 5.65) | 2.62 (1.97, 5.55) | 2.51 (1.83, 5.45) | 2.43 (1.73, 5.35) | 2.36 (1.66, 5.28) | 2.30 (1.59, 5.28) | 0.03 |
T/M | 2.30 (1.42, 2.80) | 2.01 (1.28, 2.43) | 1.76 (1.16, 2.14) | 1.54 (1.02, 1.89) | 1.37 (0.93, 1.69) | 1.25 (0.86, 1.56) | 1.18 (0.81, 1.44) | 1.12 (0.77, 1.35) | 1.09 (0.73, 1.29) | 1.05 (0.71, 1.23) | 1.03 (0.69, 1.19) | <0.001 |
CNRb | 7.39 (4.64, 13.88) | 7.02 (4.42, 13.21) | 6.60 (4.14, 12.69) | 6.11 (3.86, 12.18) | 5.72 (3.56, 11.58) | 5.30 (3.38, 10.60) | 4.85 (3.16, 10.61) | 4.49 (3.07, 10.32) | 4.26 (2.95, 10.28) | 4.08 (2.84, 10.55) | 3.94 (2.92, 10.27) | 0.02 |
CNRm | 39.20 (19.10, 66.24) | 54.63 (26.49, 89.59) | 69.30 (34.85, 119.00) | 88.89 (43.17, 149.96) | 105.58 (51.04, 169.54) | 119.96 (57.40, 190.95) | 131.03 (62.63, 212.71) | 136.51 (68.01, 225.32) | 150.86 (71.23, 239.46) | 158.40 (74.45, 258.75) | 164.58 (77.09, 262.74) | <0.001 |
n = 84 | Monochromatic Spectral Image | Iodine Map | p Value |
---|---|---|---|
T/B | |||
Average value | 3.24 ± 2.27 | 5.08 ± 4.96 | 0.002 |
Maximum value | 4.61 ± 3.67 | 7.72 ± 5.18 | <0.001 |
T/M | |||
Average value | 1.21 ± 0.32 | 2.15 ± 1.02 | <0.001 |
Maximum value | 1.36 ± 0.32 | 2.61 ± 1.05 | <0.001 |
CNRb | |||
Average value | 6.90 ± 2.77 | 10.13 ± 5.24 | <0.001 |
Maximum value | 7.92 ± 3.25 | 11.55 ± 5.69 | <0.001 |
n = 13 0–24% | Monochromatic Spectral Image | Iodine Map | p Value |
---|---|---|---|
T/B | |||
Average value | 2.53 ± 1.23 | 4.27 ± 1.74 | 0.05 |
Maximum value | 2.90 ± 1.29 | 5.82 ± 3.89 | 0.03 |
T/M | |||
Average value | 1.19 ± 0.23 | 1.83 ± 1.19 | 0.05 |
Maximum value | 1.33 ± 0.44 | 2.58 ± 1.86 | 0.008 |
CNRb | |||
Average value | 6.64 ± 1.95 | 8.65 ± 3.43 | 0.01 |
Maximum value | 7.32 ± 2.01 | 9.63 ± 3.13 | 0.007 |
n = 59 25–49% | Monochromatic Spectral Image | Iodine Map | p Value |
---|---|---|---|
T/B | |||
Average value | 3.36 ± 2.52 | 4.59 ± 3.19 | 0.01 |
Maximum value | 4.63 ± 3.47 | 7.62 ± 3.49 | 0.006 |
T/M | |||
Average value | 1.21 ± 0.37 | 2.19 ± 0.99 | 0.002 |
Maximum value | 1.36 ± 0.30 | 2.60 ± 0.69 | <0.001 |
CNRb | |||
Average value | 6.69 ± 3.15 | 10.37 ± 5.45 | 0.01 |
Maximum value | 7.19 ± 3.25 | 11.45 ± 6.70 | 0.01 |
n = 12 50–74% | Monochromatic Spectral Image | Iodine Map | p Value |
---|---|---|---|
T/B | |||
Average value | 3.67 ± 1.85 | 4.46 ± 3.49 | 0.006 |
Maximum value | 6.12 ± 5.31 | 9.91 ± 4.14 | 0.04 |
T/M | |||
Average value | 1.24 ± 0.32 | 2.22 ± 0.94 | <0.001 |
Maximum value | 1.43 ± 0.27 | 2.62 ± 0.89 | <0.001 |
CNRb | |||
Average value | 7.01 ± 2.88 | 10.54 ± 5.88 | <0.001 |
Maximum value | 8.11 ± 3.46 | 11.86 ± 5.86 | <0.001 |
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Li, J.-X.; Xie, F.-J.; Chen, C.-H.; Chen, K.-M.; Tsai, C.-J. Dual-Energy Computed Tomography for Evaluation of Breast Cancer Follow-Ups: Comparison of Virtual Monoenergetic Images and Iodine-Map. Diagnostics 2022, 12, 946. https://doi.org/10.3390/diagnostics12040946
Li J-X, Xie F-J, Chen C-H, Chen K-M, Tsai C-J. Dual-Energy Computed Tomography for Evaluation of Breast Cancer Follow-Ups: Comparison of Virtual Monoenergetic Images and Iodine-Map. Diagnostics. 2022; 12(4):946. https://doi.org/10.3390/diagnostics12040946
Chicago/Turabian StyleLi, Jun-Xian, Feng-Ji Xie, Chia-Hui Chen, Kuan-Ming Chen, and Chia-Jung Tsai. 2022. "Dual-Energy Computed Tomography for Evaluation of Breast Cancer Follow-Ups: Comparison of Virtual Monoenergetic Images and Iodine-Map" Diagnostics 12, no. 4: 946. https://doi.org/10.3390/diagnostics12040946