Blood Flow Analysis of the Great Saphenous Vein in the Su-Pine Position in Clinical Manifestations of Varicose Veins of Different Severities: Application of Phase-Contrast Magnetic Resonance Imaging Data
Abstract
:1. Introduction
2. Materials and Methods
Statistical Methods
3. Results
4. Discussion
Limitations
5. Conclusions
6. Patents
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Sequence | Parameters |
---|---|
Magnetic strength, T | 1.5 |
Manufacturer | Philips |
Model | Ingenia |
Sequence type | Three-dimensional turbo spin echo skill with short-tau inversion recovery protocol |
Phase of cardiac cycle | Systolic |
Repetition time | one beat |
Echo time (msec) | 85 |
Flip angle | 90° |
Inversion recovery delay time (msec) | 160 |
Voxel size (mm3) | 1.7 × 1.7 × 4 |
Field of view (mm) | 360 × 320 |
Variables | Patients Diagnosed with Varicose Veins N = 69 | Patients Diagnosed without Varicose Veins N = 38 | p |
---|---|---|---|
Age (years) | 61 (52.5, 72.5) | 64 (54.5, 79.3) | 0.22 |
Sex, n (%) | 0.93 | ||
Male | 23 (33.3) | 13 (34.2) | |
Female | 46 (66.7) | 25 (65.8) | |
Body mass index | 26.83 (24.61, 30.22) | 26.80 (22.77, 30.35) | 0.62 |
Comorbidities | |||
Hypertension, n (%) | 27 (39.1) | 18 (47.4) | 0.41 |
Diabetes mellitus, n (%) | 11 (15.9) | 9 (23.7) | 0.33 |
Hyperlipidemia, n (%) | 13 (18.8) | 7 (18.4) | 0.96 |
History of cerebrovascular accident, n (%) | 2 (2.9) | 3 (7.9) | 0.35 |
Chronic kidney disease, n (%) | 3 (4.3) | 2 (5.3) | 1.00 |
Coronary artery disease, n (%) | 3 (4.3) | 3 (7.9) | 0.66 |
Atrial fibrillation, n (%) | 3 (4.3) | 2 (5.3) | 1.00 |
Smoking, n (%) | |||
Yes | 7 (10.1) | 3 (7.9) | 1.00 |
Cessation | 3 (4.3) | 4 (10.5) | 0.25 |
Chronic lung disease | 4 (5.8) | 0 | 0.29 |
Leg with engorged superficial vein | |||
Right | 27 (39.1) | - | - |
Left | 12 (17.4) | - | - |
Bilateral | 30 (43.5) | - | - |
Legs without Varicose Veins n = 53 | Legs with Asymptomatic Varicose Veins n = 42 | Legs with Symptomatic Varicose Veins n = 46 | p | |
---|---|---|---|---|
Imaging findings | ||||
Compression of iliocaval territory | 18 (34.0) | 11 (26.2) | 14 (30.4) | 0.72 |
Deep vein thrombosis | 7 (13.2) | 2 (4.8) | 6 (13.0) | 0.34 |
GSV dilatation | - | 16 (38.1) | 35 (76.1) | <0.001 |
GSV to PV diameter ratio * | 0.47 (0.37, 0.63) | 0.52 (0.43, 0.75) | 0.67 (0.50, 0.79) | 0.001 |
Blood flow analysis | ||||
External iliac vein | ||||
RF (%) | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.08) | 0.39 |
ASV (mL) | 2.93 (2.02, 5.10) | 2.34 (1.85, 5.32) | 3.50 (2.53, 4.82) | 0.67 |
MF (mL/s) | 3.29 (2.22, 5.60) | 2.82 (2.01, 5.95) | 3.41 (2.51, 5.35) | 0.87 |
MV (cm/s) | 5.32 (3.95, 7.26) | 6.61 (4.56, 8.48) | 7.51 (4.79, 9.79) | 0.09 |
Femoral vein | ||||
RF (%) | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.00) | 0.56 |
ASV (mL) | 1.06 (0.48, 1.55) | 1.13 (0.82, 1.86) | 1.11 (0.78, 1.78) | 0.12 |
MF (mL/s) | 1.10 (0.65, 1.79) | 1.32 (0.94, 1.98) | 1.37 (0.85, 2.08) | 0.14 |
MV (cm/s) | 3.26 (2.21, 4.75) | 3.60 (2.61, 5.18) | 4.60 (2.88, 6.32) | 0.08 |
Popliteal vein | ||||
RF (%) | 0.00 (0.00, 1.54) | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.00) | 0.15 |
ASV (mL) | 0.63 (0.35, 1.09) | 0.80 (0.46, 1.10) | 0.77 (0.46, 1.38) | 0.26 |
MF (mL/s) | 0.71 (0.41, 1.23) | 0.85 (0.51, 1.14) | 0.89 (0.44, 1.50) | 0.27 |
MV (cm/s) | 1.54 (0.97, 2.44) | 1.70 (1.26, 2.31) | 1.95 (1.30, 3.53) | 0.13 |
Great saphenous vein | ||||
RF (%) # | 0.00 (0.00, 10.05) | 2.08 (0.00, 33.77) | 0.00 (0.00, 2.15) | 0.03 |
ASV (mL) † | 0.21 (0.12, 0.43) | 0.25 (0.16, 0.47) | 0.43 (0.22, 0.67) | 0.005 |
MF (mL/s) ‡ | 0.21 (0.11, 0.54) | 0.22 (0.08, 0.43) | 0.43 (0.21, 0.84) | 0.009 |
MV (cm/s) | 1.80 (0.76, 3.03) | 1.46 (0.55, 2.80) | 2.43 (1.10, 4.39) | 0.12 |
No Symptoms n = 42 | Discomfort or Edema n = 28 | Skin Changes or Ulcers n = 18 | p | |
---|---|---|---|---|
Imaging findings | ||||
Compression of iliocaval territory | 11 (26.2) | 7 (25.0) | 7 (38.9) | 0.54 |
Deep vein thrombosis | 2 (4.8) | 3 (10.7) | 3 (16.7) | 0.32 |
GSV dilatation * | 16 (38.1) | 22 (78.6) | 13 (72.2) | <0.001 |
GSV to PV diameter ratio # | 0.52 (0.43, 0.75) | 0.61 (0.47, 0.75) | 0.68 (0.62, 0.91) | 0.04 |
QFlow data findings | ||||
External iliac vein | ||||
RF (%) | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.11) | 0.00 (0.00, 0.09) | 0.27 |
ASV (mL) | 2.34 (1.85, 5.32) | 3.71 (2.49, 5.13) | 3.29 (2.51, 4.82) | 0.69 |
MF (mL/s) | 2.82 (2.01, 5.95) | 3.37 (2.44, 6.69) | 3.41 (2.51, 4.30) | 0.62 |
MV (cm/s) | 6.61 (4.56, 8.48) | 7.51 (4.33, 9.38) | 7.32 (4.79, 10.76) | 0.72 |
Femoral vein | ||||
RF (%) | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.00) | 0.56 |
ASV (mL) | 1.13 (0.82, 1.86) | 1.11 (0.67, 1.75) | 1.18 (0.90, 1.83) | 0.79 |
MF (mL/s) | 1.32 (0.94, 1.98) | 1.34 (0.71, 2.06) | 1.55 (0.89, 2.08) | 0.93 |
MV (cm/s) | 3.60 (2.61, 5.18) | 3.90 (2.68, 6.27) | 5.19 (3.25, 6.44) | 0.13 |
Popliteal vein | ||||
RF (%) | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.00) | 0.00 (0.00, 0.00) | 0.78 |
ASV (mL) | 0.80 (0.46, 1.10) | 0.69 (0.39, 1.23) | 0.85 (0.53, 1.50) | 0.45 |
MF (mL/s) | 0.85 (0.51, 1.14) | 0.83 (0.43, 1.30) | 1.09 (0.49, 1.77) | 0.51 |
MV (cm/s) | 1.70 (1.26, 2.31) | 1.76 (1.19, 3.66) | 2.41 (1.41, 3.19) | 0.45 |
Great saphenous vein | ||||
RF (%) † | 2.08 (0.00, 33.77) | 0.00 (0.00, 4.31) | 0.00 (0.00, 2.32) | 0.03 |
ASV (mL) ‡ | 0.25 (0.16, 0.47) | 0.33 (0.20, 0.63) | 0.49 (0.27, 0.93) | 0.03 |
MF (mL/s) § | 0.22 (0.08, 0.43) | 0.37 (0.20, 0.82) | 0.54 (0.23, 1.03) | 0.02 |
MV (cm/s) | 1.46 (0.55, 2.80) | 2.43 (1.16, 3.43) | 2.38 (0.94, 5.59) | 0.12 |
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Tseng, Y.-H.; Chen, C.-W.; Wong, M.-Y.; Yang, T.-Y.; Lin, Y.-H.; Lin, B.-S.; Huang, Y.-K. Blood Flow Analysis of the Great Saphenous Vein in the Su-Pine Position in Clinical Manifestations of Varicose Veins of Different Severities: Application of Phase-Contrast Magnetic Resonance Imaging Data. Diagnostics 2022, 12, 118. https://doi.org/10.3390/diagnostics12010118
Tseng Y-H, Chen C-W, Wong M-Y, Yang T-Y, Lin Y-H, Lin B-S, Huang Y-K. Blood Flow Analysis of the Great Saphenous Vein in the Su-Pine Position in Clinical Manifestations of Varicose Veins of Different Severities: Application of Phase-Contrast Magnetic Resonance Imaging Data. Diagnostics. 2022; 12(1):118. https://doi.org/10.3390/diagnostics12010118
Chicago/Turabian StyleTseng, Yuan-Hsi, Chien-Wei Chen, Min-Yi Wong, Teng-Yao Yang, Yu-Hui Lin, Bor-Shyh Lin, and Yao-Kuang Huang. 2022. "Blood Flow Analysis of the Great Saphenous Vein in the Su-Pine Position in Clinical Manifestations of Varicose Veins of Different Severities: Application of Phase-Contrast Magnetic Resonance Imaging Data" Diagnostics 12, no. 1: 118. https://doi.org/10.3390/diagnostics12010118
APA StyleTseng, Y.-H., Chen, C.-W., Wong, M.-Y., Yang, T.-Y., Lin, Y.-H., Lin, B.-S., & Huang, Y.-K. (2022). Blood Flow Analysis of the Great Saphenous Vein in the Su-Pine Position in Clinical Manifestations of Varicose Veins of Different Severities: Application of Phase-Contrast Magnetic Resonance Imaging Data. Diagnostics, 12(1), 118. https://doi.org/10.3390/diagnostics12010118