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miRNomic Signature in Very Low Birth-Weight Neonates Discriminates Late-Onset Gram-Positive Sepsis from Controls

1
Department of Physiology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain
2
Division of Neonatology, University & Polytechnic Hospital La Fe, 46026 Valencia, Spain
3
Health Research Institute, University & Polytechnic Hospital La Fe, 46026 Valencia, Spain
4
Igenomix R&D, 46980 Valencia, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Alessandro Russo
Diagnostics 2021, 11(8), 1389; https://doi.org/10.3390/diagnostics11081389
Received: 26 May 2021 / Revised: 26 July 2021 / Accepted: 27 July 2021 / Published: 31 July 2021
(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
Background and Objectives. Neonatal sepsis is a serious condition with a high rate of mortality and morbidity. Currently, the gold standard for sepsis diagnosis is a positive blood culture, which takes 48–72 h to yield results. We hypothesized that identifying differentially expressed miRNA pattern in neonates with late-onset Gram-positive sepsis would help with an earlier diagnosis and therapy. Methods. This is a prospective observational study in newborn infants with late-onset Gram positive bacterial sepsis and non-septic controls. Complementary to blood culture, an aliquot of 0.5 mL of blood was used to determine small non-coding RNA expression profiling using the GeneChip miRNA 4.0 Array. Results. A total of 11 very low birth-weight neonates with late-onset Gram-positive sepsis and 16 controls were analyzed. Further, 217 differentially expressed miRNAs were obtained between both groups. Subsequently, a combined analysis was performed with these miRNAs and 4297 differentially expressed genes. We identified 33 miRNAs that regulate our mRNAs, and the most relevant biological processes are associated with the immune system and the inflammatory response. Conclusions. The miRNA profiling in very low birth-weight neonates distinguishes late-onset Gram-positive sepsis versus control neonates. View Full-Text
Keywords: neonatal sepsis; miRNomic signature; very low birth-weight neonates; late-onset Gram-positive sepsis neonatal sepsis; miRNomic signature; very low birth-weight neonates; late-onset Gram-positive sepsis
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MDPI and ACS Style

Serna, E.; Parra-Llorca, A.; Panadero, J.; Vento, M.; Cernada, M. miRNomic Signature in Very Low Birth-Weight Neonates Discriminates Late-Onset Gram-Positive Sepsis from Controls. Diagnostics 2021, 11, 1389. https://doi.org/10.3390/diagnostics11081389

AMA Style

Serna E, Parra-Llorca A, Panadero J, Vento M, Cernada M. miRNomic Signature in Very Low Birth-Weight Neonates Discriminates Late-Onset Gram-Positive Sepsis from Controls. Diagnostics. 2021; 11(8):1389. https://doi.org/10.3390/diagnostics11081389

Chicago/Turabian Style

Serna, Eva, Anna Parra-Llorca, Joaquín Panadero, Máximo Vento, and María Cernada. 2021. "miRNomic Signature in Very Low Birth-Weight Neonates Discriminates Late-Onset Gram-Positive Sepsis from Controls" Diagnostics 11, no. 8: 1389. https://doi.org/10.3390/diagnostics11081389

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