Individualised Timing of Radio-Guided Parathyroidectomy Using Multi-Phase SPECT/CT Increases In Vivo Sensitivity and Accuracy and Reduces Operating Time: A Randomised Clinical Trial
Abstract
:1. Introduction
2. Methods
2.1. Ethical Considerations
2.2. Design and Setting
2.3. Participants and Randomisation
2.4. SPECT/CT
2.4.1. Group I
2.4.2. Group II
2.4.3. Surgery
2.4.4. Follow-Up
2.4.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | Group I (n = 47) | Group II (n = 35) | p-Value |
---|---|---|---|
Age, years | 64.0 (55.0–71.0) | 62.0 (53.0–67.5) | 0.183 * |
Females | 34 (72) | 27 (77) | 0.799 ** |
Males | 13 (28) | 8 (23) | |
Ectopic adenoma | 17 (36) | 12 (34) | >0.999 ** |
Result | Group I (n = 47) | Group II (n = 35) | p-Value |
---|---|---|---|
Successful surgery | 46 (98) | 35 (100) | >0.999 * |
Histology, hyperplasia | 1 (2) | 1 (3) | >0.999 * |
Histology, adenoma | 45 (96) | 34 (97) | >0.999 * |
Multiple adenomas | 1 (2) | 1 (3) | >0.999 * |
Time delay, min | 160 (125–190) | 190 (140–205) | 0.260 ** |
Parathyroid gland volume, mL | 1.8 (1.0–3.0) | 1.3 (1.0–2.4) | 0.234 ** |
Operating time, min | 40.0 (30.0–60.0) | 30.0 (26.5–35.0) | 0.003 ** |
Adenoma count rate, cpm | 1200 (860–1400) | 1200 (1100–1405) | 0.318 ** |
Background count rate, cpm | 700 (500–800) | 720 (600–850) | 0.094 ** |
In vivo index | 2.0 (1.5–2.2) | 1.8 (1.4–2.0) | 0.285 ** |
Recurrent laryngeal nerve paralysis | 1 (2) | 0 (0) | >0.999 * |
Hypocalcaemia | 2 (4) | 1 (3) | >0.999 * |
Parameter | Group I | Group II | p-Value * |
---|---|---|---|
In vivo sensitivity | 40/47 (85.1%) | 35/35 (100%) | 0.047 |
In vivo specificity | 45/47 (95.7%) | 35/35 (100%) | 0.609 |
In vivo accuracy | 85/94 (90.4%) | 70/70 (100%) | 0.021 |
Ex vivo sensitivity | 47/47 (100%) | 35/35 (100%) | >0.999 |
Ex vivo specificity | 47/47 (100%) | 35/35 (100%) | >0.999 |
Ex vivo accuracy | 94/94 (100%) | 70/70 (100%) | >0.999 |
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Formánek, M.; Dedek, V.; Koláček, M.; Havel, M.; Zeleník, K.; Komínek, P. Individualised Timing of Radio-Guided Parathyroidectomy Using Multi-Phase SPECT/CT Increases In Vivo Sensitivity and Accuracy and Reduces Operating Time: A Randomised Clinical Trial. Diagnostics 2021, 11, 677. https://doi.org/10.3390/diagnostics11040677
Formánek M, Dedek V, Koláček M, Havel M, Zeleník K, Komínek P. Individualised Timing of Radio-Guided Parathyroidectomy Using Multi-Phase SPECT/CT Increases In Vivo Sensitivity and Accuracy and Reduces Operating Time: A Randomised Clinical Trial. Diagnostics. 2021; 11(4):677. https://doi.org/10.3390/diagnostics11040677
Chicago/Turabian StyleFormánek, Martin, Vladimír Dedek, Michal Koláček, Martin Havel, Karol Zeleník, and Pavel Komínek. 2021. "Individualised Timing of Radio-Guided Parathyroidectomy Using Multi-Phase SPECT/CT Increases In Vivo Sensitivity and Accuracy and Reduces Operating Time: A Randomised Clinical Trial" Diagnostics 11, no. 4: 677. https://doi.org/10.3390/diagnostics11040677