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Prediction of Incidental Osteoporotic Fractures at Vertebral-Specific Level Using 3D Non-Linear Finite Element Parameters Derived from Routine Abdominal MDCT

1
Engineering Product Development (EPD) Pillar, Singapore University of Technology and Design (SUTD), Singapore 487372, Singapore
2
Department of Diagnostic and Interventional Neuroradiology, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Ismaninger Street 22, 81675 Munich, Germany
3
TUM-Neuroimaging Center, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany
4
Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany
5
Department of Neurosurgery, Ludwig-Maximilians-University, Marchioninistraße 15, 81377 Munich, Germany
6
Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore
*
Author to whom correspondence should be addressed.
Authors equally contributed to this work.
Academic Editor: Evangelos Terpos
Diagnostics 2021, 11(2), 208; https://doi.org/10.3390/diagnostics11020208
Received: 5 January 2021 / Revised: 27 January 2021 / Accepted: 28 January 2021 / Published: 30 January 2021
(This article belongs to the Special Issue Spine Imaging: Novel Image Acquisition Techniques and Analysis Tools)
To investigate whether finite element (FE) analysis of the spine in routine thoracic/abdominal multi-detector computed tomography (MDCT) can predict incidental osteoporotic fractures at vertebral-specific level; Baseline routine thoracic/abdominal MDCT scans of 16 subjects (8(m), mean age: 66.1 ± 8.2 years and 8(f), mean age: 64.3 ± 9.5 years) who sustained incidental osteoporotic vertebral fractures as confirmed in follow-up MDCTs were included in the current study. Thoracic and lumbar vertebrae (T5-L5) were automatically segmented, and bone mineral density (BMD), finite element (FE)-based failure-load, and failure-displacement were determined. These values of individual vertebrae were normalized globally (g), by dividing the absolute value with the average of L1-3 and locally by dividing the absolute value with the average of T5-12 and L1-5 for thoracic and lumbar vertebrae, respectively. Mean-BMD of L1-3 was determined as reference. Receiver operating characteristics (ROC) and area under the curve (AUC) were calculated for different normalized FE (Kload, Kdisplacement,K(load)g, and K(displacement)g) and BMD (KBMD, and K(BMD)g) ratio parameter combinations for identifying incidental fractures. Kload, K(load)g, KBMD, and K(BMD)g showed significantly higher discriminative power compared to standard mean BMD of L1-3 (BMDStandard) (AUC = 0.67 for Kload; 0.64 for K(load)g; 0.64 for KBMD; 0.61 for K(BMD)g vs. 0.54 for BMDStandard). The combination of Kload, Kdisplacement, and KBMD increased the AUC further up to 0.77 (p < 0.001). The combination of FE with BMD measurements derived from routine thoracic/abdominal MDCT allowed an improved prediction of incidental fractures at vertebral-specific level. View Full-Text
Keywords: finite element analysis; multidetector computed tomography; osteoporosis; spine; incidental vertebral fracture finite element analysis; multidetector computed tomography; osteoporosis; spine; incidental vertebral fracture
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MDPI and ACS Style

Yeung, L.Y.; Rayudu, N.M.; Löffler, M.; Sekuboyina, A.; Burian, E.; Sollmann, N.; Dieckmeyer, M.; Greve, T.; Kirschke, J.S.; Subburaj, K.; Baum, T. Prediction of Incidental Osteoporotic Fractures at Vertebral-Specific Level Using 3D Non-Linear Finite Element Parameters Derived from Routine Abdominal MDCT. Diagnostics 2021, 11, 208. https://doi.org/10.3390/diagnostics11020208

AMA Style

Yeung LY, Rayudu NM, Löffler M, Sekuboyina A, Burian E, Sollmann N, Dieckmeyer M, Greve T, Kirschke JS, Subburaj K, Baum T. Prediction of Incidental Osteoporotic Fractures at Vertebral-Specific Level Using 3D Non-Linear Finite Element Parameters Derived from Routine Abdominal MDCT. Diagnostics. 2021; 11(2):208. https://doi.org/10.3390/diagnostics11020208

Chicago/Turabian Style

Yeung, Long Y., Nithin M. Rayudu, Maximilian Löffler, Anjany Sekuboyina, Egon Burian, Nico Sollmann, Michael Dieckmeyer, Tobias Greve, Jan S. Kirschke, Karupppasamy Subburaj, and Thomas Baum. 2021. "Prediction of Incidental Osteoporotic Fractures at Vertebral-Specific Level Using 3D Non-Linear Finite Element Parameters Derived from Routine Abdominal MDCT" Diagnostics 11, no. 2: 208. https://doi.org/10.3390/diagnostics11020208

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