Longitudinal Monitoring of Plasma Circulating Tumour DNA Enables the Prediction of Early Relapse in Patients with Non-Hodgkin Lymphoma: A Case Series
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. CAR T Cell Production
2.3. Clinical Protocol for CAR T Cell Therapy
2.4. Positron Emission Tomography (PET) Scans
2.5. Bone Marrow Cytological Examination
2.6. Phenotypic Analysis by Flow Cytometry
2.7. Cell-Free DNA Extraction
2.8. Probe Design
2.9. Droplet Digital PCR
3. Case Presentations
3.1. Case 1
3.2. Case 2
3.3. Case 3
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Ji, H.; Long, X.; Gu, J.; Jin, J.; Mao, X.; Wang, Z.; Ma, H.; Chen, L. Longitudinal Monitoring of Plasma Circulating Tumour DNA Enables the Prediction of Early Relapse in Patients with Non-Hodgkin Lymphoma: A Case Series. Diagnostics 2021, 11, 2055. https://doi.org/10.3390/diagnostics11112055
Ji H, Long X, Gu J, Jin J, Mao X, Wang Z, Ma H, Chen L. Longitudinal Monitoring of Plasma Circulating Tumour DNA Enables the Prediction of Early Relapse in Patients with Non-Hodgkin Lymphoma: A Case Series. Diagnostics. 2021; 11(11):2055. https://doi.org/10.3390/diagnostics11112055
Chicago/Turabian StyleJi, Hongyan, Xiaolu Long, Jia Gu, Jin Jin, Xia Mao, Zhiqiong Wang, Heng Ma, and Liting Chen. 2021. "Longitudinal Monitoring of Plasma Circulating Tumour DNA Enables the Prediction of Early Relapse in Patients with Non-Hodgkin Lymphoma: A Case Series" Diagnostics 11, no. 11: 2055. https://doi.org/10.3390/diagnostics11112055
APA StyleJi, H., Long, X., Gu, J., Jin, J., Mao, X., Wang, Z., Ma, H., & Chen, L. (2021). Longitudinal Monitoring of Plasma Circulating Tumour DNA Enables the Prediction of Early Relapse in Patients with Non-Hodgkin Lymphoma: A Case Series. Diagnostics, 11(11), 2055. https://doi.org/10.3390/diagnostics11112055