Is It Possible to Establish a Reliable Correlation between Maximum Standardized Uptake Value of 18-Fluorine Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Histological Types of Non-Small Cell Lung Cancer? Analysis of the Italian VATS Group Database
Abstract
:1. Introduction
2. Material and Methods
2.1. Study Design
2.2. PET/CT Image Acquisition
2.3. Endpoints of the Study
2.4. Data Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Italian VATS Group Collaborator List
Conflicts of Interest
References
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Clinical Data | N | % | Mean | Interval |
---|---|---|---|---|
Gender | ||||
Male | 4879 | 59.9% | ||
Female | 3260 | 40.1% | ||
Age | 67.9 | 18–90 | ||
Nodule Size (CT) | ||||
Group 0 (T < 2 cm) | 3869 | 47.6% | ||
Group 1 (2.1 < T > 3 cm) | 2198 | 27% | ||
Group 2 (3.1 < T > 5 cm) | 1669 | 20.5% | ||
Group 3 (5.1 < T > 7 cm) | 345 | 4.2% | ||
Group 4 (T > 7 cm) | 58 | 0.7% | ||
Nodule Density (CT) | ||||
Solid | 6469 | 79.5% | ||
Part-solid | 1452 | 17.8% | ||
Pure GGO | 218 | 2.7% | ||
SUVmax (PET) | 6.19 | 0–78 | ||
Type of lesion | ||||
Malignant (primary) | 7783 | 95.6% | ||
Malignant (secondary) | 356 | 4.4% | ||
Type of resection | ||||
Upper Lobectomy | 4407 | 54.1% | ||
Middle Lobectomy | 590 | 7.3% | ||
Lower Lobectomy | 2742 | 33.7% | ||
Upper Bilobectomy | 69 | 0.9% | ||
Lower Bilobectomy | 49 | 0.6% | ||
Basal Segmentectomy | 39 | 0.5% | ||
Apical segmentectomy of upper lobe | 99 | 1.2% | ||
Apical segmentectomy of lower lobe | 83 | 1.0% | ||
Lingulectomy | 61 | 0.7% |
Types | N | % | |
---|---|---|---|
Adenocarcinoma * | |||
Path 0 | Preinvasive lesion | 187 | 2.3% |
Path 1 | Minimally invasive | 767 | 9.4% |
Path 2 | Invasive Adenocarcinoma | 4580 | 56.3% |
Path 3 | Squamous Cell Carcinoma * | 1254 | 15.4% |
Path 4 | Adenosquamous Cell Carcinoma | 90 | 1.1% |
Path 5 | Pleomorphic Carcinoma | 33 | 0.4% |
Neuroendocrine Tumors * | |||
Path 6 | Typical Carcinoid | 448 | 5.5% |
Path 7 | Atypical Carcinoid | 107 | 1.3% |
Path 8 | Small Cell Lung Cancer | 60 | 0.7% |
Path 9 | Large Cell Neuroendocrine Carcinoma | 180 | 2.2% |
Other Carcinomas * | |||
Path 10 | NSCLC NAS | 23 | 0.3% |
Path 11 | Mucoepidermoid Carcinoma | 7 | 0.1% |
Path 12 | Carcinosarcoma | 26 | 0.3% |
Path 13 | Adenoidocystic Carcinoma | 13 | 0.2% |
Path 14 | Lymphoma * | 8 | 0.1% |
Path 15 | Metastatic Cancer * | 356 | 4.4% |
N | Mean | St. Dev | Median | Min | Max | |
---|---|---|---|---|---|---|
Path 0 | 187 | 4.88 | 3.82 | 4.00 | 0.00 | 24.00 |
Path 1 | 767 | 5.49 | 4.10 | 4.10 | 0.00 | 31.00 |
Path 2 | 4580 | 5.87 | 4.18 | 4.70 | 0.00 | 45.00 |
Path 3 | 1254 | 8.85 | 6.70 | 8.00 | 0.00 | 51.00 |
Path 4 | 90 | 6.55 | 5.39 | 6.00 | 0.00 | 21.00 |
Path 5 | 33 | 8.15 | 6.47 | 8.50 | 0.00 | 24.00 |
Path 6 | 448 | 3.83 | 2.76 | 3.00 | 0.00 | 78.00 |
Path 7 | 107 | 6.41 | 3.48 | 4.00 | 0.00 | 77.00 |
Path 8 | 60 | 7.13 | 5.05 | 6.65 | 0.00 | 21.46 |
Path 9 | 180 | 8.64 | 6.07 | 7.27 | 0.00 | 39.00 |
Path 10 | 23 | 7.11 | 5.51 | 7.00 | 0.00 | 18.39 |
Path 11 | 7 | 3.86 | 3.13 | 4.00 | 0.00 | 8.00 |
Path 12 | 26 | 9.36 | 7.30 | 8.00 | 0.00 | 28.00 |
Path 13 | 13 | 4.00 | 3.39 | 4.80 | 0.00 | 10.00 |
Path 14 | 8 | 3.41 | 2.56 | 3.00 | 0.00 | 8.00 |
Path 15 | 356 | 5.57 | 3.57 | 4.60 | 0.00 | 31.00 |
STAGE | N | % |
---|---|---|
IA1 | 2148 | 31.1% |
IA2 | 1868 | 27% |
IA3 | 715 | 10.3% |
IB | 1061 | 15.3% |
IIA | 190 | 2.8% |
IIB | 580 | 8.4% |
IIIA | 301 | 4.4% |
IIIB | 45 | 0.7% |
IIIC | 3 | 0% |
Pathology | N | Average Rank | Different (p < 0.05) from Factor Nr. |
---|---|---|---|
Path 0 | 187 | 3094.74 | 3 |
Path 1 | 767 | 3357.34 | 2–3 |
Path 2 | 4580 | 3177.57 | 1–3 |
Path 3 | 1254 | 4254.24 | 0–1–2 |
Figure | N | Average Rank | Different (p < 0.05) from Factor Nr. |
---|---|---|---|
0 (<2 cm) | 3052 | 2788.82 | 1–2–3–4 |
1 (between 2.1 and 3 cm) | 1876 | 3651.76 | 0–2–3–4 |
2 (between 3.1 and 5 cm) | 1464 | 4083.42 | 0–1–3–4 |
3 (between 5.1 and 7 cm) | 323 | 4729.68 | 0–1–2 |
4 (>7 cm) | 73 | 4694.71 | 0–1–2 |
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Divisi, D.; Rinaldi, M.; Necozione, S.; Curcio, C.; Rea, F.; Zaraca, F.; De Vico, A.; Zaccagna, G.; Di Leonardo, G.; Crisci, R.; et al. Is It Possible to Establish a Reliable Correlation between Maximum Standardized Uptake Value of 18-Fluorine Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Histological Types of Non-Small Cell Lung Cancer? Analysis of the Italian VATS Group Database. Diagnostics 2021, 11, 1901. https://doi.org/10.3390/diagnostics11101901
Divisi D, Rinaldi M, Necozione S, Curcio C, Rea F, Zaraca F, De Vico A, Zaccagna G, Di Leonardo G, Crisci R, et al. Is It Possible to Establish a Reliable Correlation between Maximum Standardized Uptake Value of 18-Fluorine Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Histological Types of Non-Small Cell Lung Cancer? Analysis of the Italian VATS Group Database. Diagnostics. 2021; 11(10):1901. https://doi.org/10.3390/diagnostics11101901
Chicago/Turabian StyleDivisi, Duilio, Marta Rinaldi, Stefano Necozione, Carlo Curcio, Federico Rea, Francesco Zaraca, Andrea De Vico, Gino Zaccagna, Gabriella Di Leonardo, Roberto Crisci, and et al. 2021. "Is It Possible to Establish a Reliable Correlation between Maximum Standardized Uptake Value of 18-Fluorine Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Histological Types of Non-Small Cell Lung Cancer? Analysis of the Italian VATS Group Database" Diagnostics 11, no. 10: 1901. https://doi.org/10.3390/diagnostics11101901
APA StyleDivisi, D., Rinaldi, M., Necozione, S., Curcio, C., Rea, F., Zaraca, F., De Vico, A., Zaccagna, G., Di Leonardo, G., Crisci, R., & on behalf of the Italian VATS Group. (2021). Is It Possible to Establish a Reliable Correlation between Maximum Standardized Uptake Value of 18-Fluorine Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Histological Types of Non-Small Cell Lung Cancer? Analysis of the Italian VATS Group Database. Diagnostics, 11(10), 1901. https://doi.org/10.3390/diagnostics11101901