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Self-Collected versus Healthcare Worker-Collected Swabs in the Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2

1
Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark
2
Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark
3
Department of Clinical Microbiology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark
4
Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark
5
Department of Cardiology, Copenhagen University Hospital Herlev, 2730 Herlev, Denmark
6
Copenhagen Academy for Medical Education and Simulation, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(9), 678; https://doi.org/10.3390/diagnostics10090678
Received: 23 August 2020 / Revised: 4 September 2020 / Accepted: 7 September 2020 / Published: 9 September 2020
(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
The aim of this study was to compare the sensitivity of self-collected versus healthcare worker (HCW)-collected swabs for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) testing. Symptomatic individuals referred for SARS-CoV-2 testing were invited to provide mobile-phone video-instructed self-collected oropharyngeal and nasal samples followed by a HCW-collected oropharyngeal sample. All samples were sent for analysis to the same microbiology laboratory, and the number of SARS-CoV-2-positive participants in the two tests was compared. A total of 109 participants were included, and 19 participants had SARS-CoV-2-positive results. The diagnostic sensitivity of the self-collected and HCW-collected swabs was 84.2% and 89.5%, respectively, with an acceptable agreement, Cohens kappa 0.82, p < 0.001. Further, results from a questionnaire answered by the participants found that loss of smell as a self-reported symptom was a strong predictor for a SARS-CoV-2-positive test. In conclusion, we found that self-collected oropharyngeal and nasal swabs for SARS-CoV-2 testing can be reliable compared to HCW-collected oropharyngeal samples. View Full-Text
Keywords: COVID-19; COVID-19 diagnostic testing; severe acute respiratory syndrome coronavirus 2 COVID-19; COVID-19 diagnostic testing; severe acute respiratory syndrome coronavirus 2
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MDPI and ACS Style

Therchilsen, J.H.; von Buchwald, C.; Koch, A.; Dam Nielsen, S.; Rasmussen, D.B.; Thudium, R.F.; Kirkby, N.S.; Raaschou-Pedersen, D.E.T.; Bundgaard, J.S.; Iversen, K.; Bundgaard, H.; Todsen, T. Self-Collected versus Healthcare Worker-Collected Swabs in the Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2. Diagnostics 2020, 10, 678. https://doi.org/10.3390/diagnostics10090678

AMA Style

Therchilsen JH, von Buchwald C, Koch A, Dam Nielsen S, Rasmussen DB, Thudium RF, Kirkby NS, Raaschou-Pedersen DET, Bundgaard JS, Iversen K, Bundgaard H, Todsen T. Self-Collected versus Healthcare Worker-Collected Swabs in the Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2. Diagnostics. 2020; 10(9):678. https://doi.org/10.3390/diagnostics10090678

Chicago/Turabian Style

Therchilsen, Johan H.; von Buchwald, Christian; Koch, Anders; Dam Nielsen, Susanne; Rasmussen, Daniel B.; Thudium, Rebekka F.; Kirkby, Nikolai S.; Raaschou-Pedersen, Daniel E.T.; Bundgaard, Johan S.; Iversen, Kasper; Bundgaard, Henning; Todsen, Tobias. 2020. "Self-Collected versus Healthcare Worker-Collected Swabs in the Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2" Diagnostics 10, no. 9: 678. https://doi.org/10.3390/diagnostics10090678

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