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Open AccessReview

Role of pH Value in Clinically Relevant Diagnosis

Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan
College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
Authors to whom correspondence should be addressed.
Diagnostics 2020, 10(2), 107;
Received: 17 December 2019 / Revised: 14 February 2020 / Accepted: 14 February 2020 / Published: 16 February 2020
(This article belongs to the Special Issue Point-of-Care Detection Devices for Healthcare)
As a highly influential physiological factor, pH may be leveraged as a tool to diagnose physiological state. It may be especially suitable for diagnosing and assessing skin structure and wound status. Multiple innovative and elegant smart wound dressings combined with either pH sensors or drug control-released carriers have been extensively studied. Increasing our understanding of the role of pH value in clinically relevant diagnostics should assist clinicians and improve personal health management in the home. In this review, we summarized a number of articles and discussed the role of pH on the skin surface as well as the factors that influence skin pH and pH-relevant skin diseases, but also the relationship of skin pH to the wound healing process, including its influence on the activity of proteases, bacterial enterotoxin, and some antibacterial agents. A great number of papers discussing physiological pH value have been published in recent decades, far too many to be included in this review. Here, we have focused on the impact of pH on wounds and skin with an emphasis on clinically relevant diagnosis toward effective treatment. We have also summarized the differences in skin structure and wound care between adults and infants, noting that infants have fragile skin and poor skin barriers, which makes them more vulnerable to skin damage and compels particular care, especially for wounds. View Full-Text
Keywords: pH value; diagnosis; skin; wound pH value; diagnosis; skin; wound
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Kuo, S.-H.; Shen, C.-J.; Shen, C.-F.; Cheng, C.-M. Role of pH Value in Clinically Relevant Diagnosis. Diagnostics 2020, 10, 107.

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