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Dissecting the Repertoire of DNA-Binding Transcription Factors of the Archaeon Pyrococcus furiosus DSM 3638

1
Facultad de Medicina, Universidad Juárez Autónoma de Tabasco, C.P. 86100 Tabasco, Mexico
2
Facultad de Ciencias, Universidad Nacional Autónoma de México, Unidad Académica de Ciencias y Tecnología de la UNAM en Yucatán, Carretera Sierra Papacal-Chuburna Km. 5, C.P. 97302 Mérida, Yucatán, Mexico
3
Tecnológico Nacional de México, Instituto Tecnológico de Mérida, C.P. 97000 Mérida, Yucatán, Mexico
4
Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas, Universidad Nacional Autónoma de México, Unidad Académica Yucatán, C.P. 97302 Mérida, Yucatán, Mexico
*
Authors to whom correspondence should be addressed.
Received: 5 July 2018 / Revised: 11 September 2018 / Accepted: 19 September 2018 / Published: 21 September 2018
(This article belongs to the Section Life Sciences)
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Abstract

In recent years, there has been a large increase in the amount of experimental evidence for diverse archaeal organisms, and these findings allow for a comprehensive analysis of archaeal genetic organization. However, studies about regulatory mechanisms in this cellular domain are still limited. In this context, we identified a repertoire of 86 DNA-binding transcription factors (TFs) in the archaeon Pyrococcus furiosus DSM 3638, that are clustered into 32 evolutionary families. In structural terms, 45% of these proteins are composed of one structural domain, 41% have two domains, and 14% have three structural domains. The most abundant DNA-binding domain corresponds to the winged helix-turn-helix domain; with few alternative DNA-binding domains. We also identified seven regulons, which represent 13.5% (279 genes) of the total genes in this archaeon. These analyses increase our knowledge about gene regulation in P. furiosus DSM 3638 and provide additional clues for comprehensive modeling of transcriptional regulatory networks in the Archaea cellular domain. View Full-Text
Keywords: transcription factors; DNA-binding domain; regulatory interaction; archaeon; regulatory network transcription factors; DNA-binding domain; regulatory interaction; archaeon; regulatory network
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Denis, A.; Martínez-Núñez, M.A.; Tenorio-Salgado, S.; Perez-Rueda, E. Dissecting the Repertoire of DNA-Binding Transcription Factors of the Archaeon Pyrococcus furiosus DSM 3638. Life 2018, 8, 40.

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