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Controlled Construction of Stable Network Structure Composed of Honeycomb-Shaped Microhydrogels

RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan
Department of Computer Science, School of Computing, Tokyo Institute of Technology, Yokohama, Kanagawa 226-8502, Japan
School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa 923-1292, Japan
Department of Mechanical Engineering, Keio University, Yokohama, Kanagawa 223-8522, Japan
Author to whom correspondence should be addressed.
Received: 21 August 2018 / Revised: 14 September 2018 / Accepted: 16 September 2018 / Published: 20 September 2018
(This article belongs to the Special Issue Approaches toward Artificial Cell Construction and Applications)
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Recently, the construction of models for multicellular systems such as tissues has been attracting great interest. These model systems are expected to reproduce a cell communication network and provide insight into complicated functions in living systems./Such network structures have mainly been modelled using a droplet and a vesicle. However, in the droplet and vesicle network, there are difficulties attributed to structural instabilities due to external stimuli and perturbations. Thus, the fabrication of a network composed of a stable component such as hydrogel is desired. In this article, the construction of a stable network composed of honeycomb-shaped microhydrogels is described. We produced the microhydrogel network using a centrifugal microfluidic technique and a photosensitive polymer. In the network, densely packed honeycomb-shaped microhydrogels were observed. Additionally, we successfully controlled the degree of packing of microhydrogels in the network by changing the centrifugal force. We believe that our stable network will contribute to the study of cell communication in multicellular systems. View Full-Text
Keywords: cell communication; artificial cell/tissue; microhydrogel network; microfluidics cell communication; artificial cell/tissue; microhydrogel network; microfluidics

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Hayakawa, M.; Umeyama, S.; Nagai, K.H.; Onoe, H.; Takinoue, M. Controlled Construction of Stable Network Structure Composed of Honeycomb-Shaped Microhydrogels. Life 2018, 8, 38.

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