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Formaldehyde—A Key Monad of the Biomolecular System

Department of Medicinal Chemistry, Faculty of Life Science University of Vienna, Althanstr. 14, Vienna 1090, Austria
Department of Pharmaceutical Chemistry, University of Frankfurt, Max-von-Laue-Str. 9, Frankfurt D-60438, Germany
Author to whom correspondence should be addressed.
Current address: Merial Ltd., 3239 Satellite Blvd., Duluth, GA 30096, USA.
This publication is dedicated to Simon Eppacher, who died tragically in the time of the preparation of this manuscript.
Life 2013, 3(3), 486-501;
Received: 2 May 2013 / Revised: 17 July 2013 / Accepted: 30 July 2013 / Published: 16 August 2013
PDF [295 KB, uploaded 21 August 2013]


Experiments will be presented and reviewed to support the hypothesis that the intrinsic reactivity of formaldehyde may lead to the formation of a rather comprehensive set of defined biomolecules, including D-glucose, thus fostering concepts of evolution considering the existence of a premetabolic system as a primordial step in the generation of life. View Full-Text
Keywords: formaldehyde; D-glucose; prebiotic; stereoelectronic effect; helical chirality formaldehyde; D-glucose; prebiotic; stereoelectronic effect; helical chirality

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Noe, C.R.; Freissmuth, J.; Richter, P.; Miculka, C.; Lachmann, B.; Eppacher, S. Formaldehyde—A Key Monad of the Biomolecular System. Life 2013, 3, 486-501.

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