Prognostic Factors of Postoperative Mortality in Patients with Complicated Right Colon Cancer
Abstract
:1. Introduction
2. Material and Methods
3. Result
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Postoperative Deaths—No | Postoperative Deaths—Yes | p-Value (Test) | ||
---|---|---|---|---|
Age group | ≤68 years | 38/83 (45.78%) | 5/12 (41.67%) | 0.789 (1) |
>68 years | 45/83 (54.22%) | 7/12 (58.33%) | ||
Sex | M | 41/83 (49.40%) | 11/12 (91.67%) | 0.006 (1) |
F | 42/83 (50.60%) | 1/12 (8.33%) | ||
Urban/rural area | U | 60/83 (72.29%) | 9/12 (75.00%) | 0.844 (1) |
R | 23/83 (27.71%) | 3/12 (25.00%) | ||
Abdominal pain | No | 3/83 (3.61%) | 2/12 (16.67%) | 0.058 (1) |
Yes | 80/83 (96.39%) | 10/12 (83.33%) | ||
Absence of transit | No | 43/83 (51.81%) | 6/12 (50.00%) | 0.907 (1) |
Yes | 40/83 (48.19%) | 6/12 (50.00%) | ||
Nausea | No | 8/83 (9.64%) | 2/12 (16.67%) | 0.458 (1) |
Yes | 75/83 (90.36%) | 10/12 (83.33%) | ||
Vomiting | No | 28/83 (33.73%) | 6/12 (50.00%) | 0.272 (1) |
Yes | 55/83 (66.27%) | 6/12 (50.00%) | ||
Weight loss | No | 74/83 (89.16%) | 5/12 (41.67%) | 0.000 (1) |
Yes | 9/83 (10.84%) | 7/12 (58.33%) | ||
Lower digestive hemorrhage | No | 78/83 (93.98%) | 11/12 (91.67%) | 0.759 (1) |
Yes | 5/83 (6.02%) | 1/12 (8.33%) | ||
Personal history of non-neoplastic pathology 1/0 | No | 31/83 (37.35%) | 2/12 (16.67%) | 0.160 (1) |
Yes | 52/83 (62.65%) | 10/12 (83.33%) | ||
Personal history of neoplastic pathology 1/0 | No | 81/83 (97.59%) | 11/12 (91.67%) | 0.273 (1) |
Yes | 2/83 (2.41%) | 1/12 (8.33%) | ||
Onset of symptoms | ≤1 day | 7/83 (8.43%) | 0/12 (0.00%) | 0.277 (2) |
2–5 days | 47/83 (56.63%) | 6/12 (50.00%) | ||
>14 days | 29/83 (34.94%) | 6/12 (50.00%) | ||
Type of general status | 0 | 18/83 (21.69%) | 0/12 (0.00%) | 0.000 (2) |
1 | 30/83 (36.14%) | 1/12 (8.33%) | ||
2 | 27/83 (32.53%) | 4/12 (33.33%) | ||
3 | 6/83 (7.23%) | 3/12 (25.00%) | ||
4 | 2/83 (2.41%) | 4/12 (33.33%) | ||
Cachexia | No | 76/83 (91.57%) | 4/12 (33.33%) | 0.000 (1) |
Yes | 7/83 (8.43%) | 8/12 (66.67%) | ||
Leukocytes | N | 46/83 (55.42%) | 2/12 (16.67%) | 0.012 (1) |
P | 37/83 (44.58%) | 10/12 (83.33%) | ||
Anemia | No | 21/83 (25.30%) | 0/12 (0.00%) | 0.048 (1) |
Yes | 62/83 (74.70%) | 12/12 (100.00%) | ||
Platelets | P | 7/83 (8.43%) | 7/12 (58.33%) | 0.000 (1) |
N | 76/83 (91.57%) | 5/12 (41.67%) | ||
Blood glucose | P | 19/83 (22.89%) | 7/12 (58.33%) | 0.010 (1) |
N | 64/83 (77.11%) | 5/12 (41.67%) | ||
Creatinine | P | 30/83 (36.14%) | 8/12 (66.67%) | 0.044 (1) |
N | 53/83 (63.86%) | 4/12 (33.33%) | ||
Electrolyte disorders | No | 57/83 (68.67%) | 3/12 (25.00%) | 0.003 (1) |
Yes | 26/83 (31.33%) | 9/12 (75.00%) | ||
Acidosis | No | 68/83 (81.93%) | 7/12 (58.33%) | 0.061 (1) |
Yes | 15/83 (18.07%) | 5/12 (41.67%) | ||
Total proteins | N | 10/83 (12.05%) | 0/12 (0.00%) | 0.039 (1) |
P | 12/83 (14.46%) | 6/12 (50.00%) | ||
Albumin | N | 7/83 (8.43%) | 0/12 (0.00%) | 0.186 (1) |
P | 11/83 (13.25%) | 3/12 (25.00%) | ||
Coagulation disorders | No | 73/83 (87.95%) | 9/12 (75.00%) | 0.222 (1) |
Yes | 10/83 (12.05%) | 3/12 (25.00%) | ||
Location code | C18.0 | 36/83 (43.37%) | 6/12 (50.00%) | 0.738 (2) |
C18.2 | 17/83 (20.48%) | 3/12 (25.00%) | ||
C18.3 | 30/83 (36.14%) | 3/12 (25.00%) | ||
Preoperative diagnosis | H | 8/83 (9.64%) | 1/12 (8.33%) | 0.227 (2) |
O | 69/83 (83.13%) | 8/12 (66.67%) | ||
P | 6/83 (7.23%) | 3/12 (25.00%) | ||
Intraoperative complications | No | 80/83 (96.39%) | 11/12 (91.67%) | 0.447 (1) |
Yes | 3/83 (3.61%) | 1/12 (8.33%) | ||
Septic status | No | 81/83 (97.59%) | 8/12 (66.67%) | 0.000 (1) |
Yes | 2/83 (2.41%) | 4/12 (33.33%) | ||
Interval-intervention | <12 h | 36/83 (43.37%) | 6/12 (50.00%) | 0.659 (2) |
12–24 h | 15/83 (18.07%) | 1/12 (8.33%) | ||
>24 h | 32/83 (38.55%) | 5/12 (41.67%) | ||
Scar abdomen | No | 64/83 (77.11%) | 7/12 (58.33%) | 0.162 (1) |
Yes | 19/83 (22.89%) | 5/12 (41.67%) | ||
Operation type | 1 | 2/83 (2.41%) | 1/12 (8.33%) | 0.353 (2) |
3 | 17/83 (20.48%) | 4/12 (33.33%) | ||
4 | 64/83 (77.11%) | 7/12 (58.33%) | ||
Associated maneuvers | - | 71/83 (85.54%) | 7/12 (58.33%) | 0.112 (2) |
Major | 7/83 (8.43%) | 3/12 (25.00%) | ||
Minor | 5/83 (6.02%) | 2/12 (16.67%) | ||
Other organ invasion | No | 69/83 (83.13%) | 11/12 (91.67%) | 0.449 (1) |
Yes | 14/83 (16.87%) | 1/12 (8.33%) | ||
Metastases | No | 64/83 (77.11%) | 8/12 (66.67%) | 0.430 (1) |
Yes | 19/83 (22.89%) | 4/12 (33.33%) | ||
Preparation of colon | No | 3/83 (3.61%) | 2/12 (16.67%) | 0.058 (1) |
Yes | 80/83 (96.39%) | 10/12 (83.33%) | ||
Postoperative complications | No | 69/83 (83.13%) | 0/12 (0.00%) | 0.000 (1) |
Yes | 14/83 (16.87%) | 12/12 (100.00%) | ||
Reinterventions | No | 80/83 (96.39%) | 12/12 (100.00%) | 0.503 (1) |
Yes | 3/83 (3.61%) | 0/12 (0.00%) | ||
Scheme type | 1 | 44/83 (53.01%) | 4/12 (33.33%) | 0.110 (2) |
2 | 23/83 (27.71%) | 5/12 (41.67%) | ||
3 | 12/83 (14.46%) | 2/12 (16.67%) | ||
4 | 4/83 (4.82%) | 1/12 (8.33%) | ||
Number of hospitalization days | <15 days | 31/83 (37.35%) | 7/12 (58.33) | 0.165 (2) |
≥15 days | 52/83 (62.65%) | 5/12 (41.67) | ||
Total | 83 | 12 |
Descriptive Statistics | |||||
---|---|---|---|---|---|
Minimum | Maximum | Mean | Std. Deviation | Variance | |
Age | 42.0 | 87.0 | 67.600 | 10.9218 | 119.285 |
Duration of surgical intervention (hours) | 1.0 | 4.0 | 2.205 | 0.5812 | 0.338 |
Davies score | 1.0 | 4.0 | 1.811 | 0.7621 | 0.581 |
Charlson score | 2.0 | 11.0 | 4.453 | 2.8649 | 8.208 |
Charlson adjusted score | 6.0 | 18.0 | 10.811 | 3.2000 | 10.240 |
Number of hospitalization days | 1.0 | 48.0 | 16.084 | 7.0328 | 49.461 |
Postoperative Deaths | N | Mean | Std. Deviation | Std. Error Mean | |
---|---|---|---|---|---|
Davies score | NO | 83 (87.37%) | 1.759 | 0.7423 | 0.0815 |
YES | 12 (12.63%) | 2.167 | 0.8348 | 0.2410 | |
Charlson score | NO | 83 (87.37%) | 4.265 | 2.8331 | 0.3110 |
YES | 12 (12.63%) | 5.750 | 2.8644 | 0.8269 | |
Charlson adjusted score | NO | 83 (87.37%) | 10.639 | 3.1990 | 0.3511 |
YES | 12 (12.63%) | 12.000 | 3.0748 | 0.8876 | |
Number of hospitalization days | NO | 83 (87.37%) | 16.494 | 6.0975 | 0.6693 |
YES | 12 (12.63%) | 13.250 | 11.6395 | 3.3600 |
Mean Estimate | p-Value Log Rank (Mantel–Cox) | Univariate | |||
---|---|---|---|---|---|
HR (95%CI) | p-Value | ||||
Age group | ≤68 years | 79.953 | 0.845 | 1.120 (0.355, 3.529) | 0.846 |
>68 years | 79.115 | ||||
Sex | M | 72.481 | 0.007 | 0.102 (0.013, 0.787) | 0.029 |
F | 87.977 | ||||
Urban/rural area | U | 79.145 | 0.835 | 0.871 (0.236, 3.271) | 0.836 |
R | 80.423 | ||||
Abdominal pain | NO | 59.200 | 0.071 | 0.273 (0.060, 1.246) | 0.094 |
YES | 80.622 | ||||
Absence of transit | NO | 79.857 | 0.897 | 1.077 (0.347, 3.339) | 0.898 |
YES | 79.109 | ||||
Nausea | NO | 73.800 | 0.487 | 0.589 (0.129, 2.690) | 0.495 |
YES | 80.165 | ||||
Vomiting | NO | 75.912 | 0.317 | 0.567 (0.183, 1.758) | 0.326 |
YES | 81.492 | ||||
Weight loss | NO | 84.899 | 0.000 | 8.941 (2.824, 28.303) | 0.000 |
YES | 52.813 | ||||
Lower digestive hemorrhage | NO | 79.708 | 0.769 | 1.355 (0.175, 10.496) | 0.771 |
YES | 76.333 | ||||
Personal history of non-neoplastic pathology 1/0 | NO | 85.242 | 0.152 | 2.867 (0.628, 13.087) | 0.174 |
YES | 76.435 | ||||
Personal history of neoplastic pathology 1/0 | NO | 80.043 | 0.267 | 2.995 (0.386, 23.239) | 0.294 |
YES | 62.667 | ||||
Onset of symptoms | ≤1 day | 0.459 | 1.344 (0.790, 2.285) | 0.276 | |
2–5 days | |||||
>14 days | |||||
Cachexia | NO | 85.863 | 0.000 | 14.179 (4.246, 47.346) | 0.000 |
YES | 45.533 | ||||
White blood cells | N | 86.542 | 0.012 | 5.565 (1.219, 25.408) | 0.027 |
P | 72.298 | ||||
Anemia | NO | 0.054 | 30.467 (0.101, 9195.175) | 0.271 | |
YES | |||||
Platelets | P | 48.500 | 0.000 | 0.097 (0.031, 0.307) | 0.000 |
N | 84.852 | ||||
Blood glucose | P | 67.538 | 0.008 | 0.243 (0.077, 0.766) | 0.016 |
N | 84.000 | ||||
Creatinine | P | 72.395 | 0.043 | 0.312 (0.094, 1.037) | 0.047 |
N | 84.228 | ||||
Electrolyte disorders | NO | 85.850 | 0.003 | 5711 (1.545, 21.105) | 0.009 |
YES | 68.600 | ||||
Acidosis | NO | 82.360 | 0.048 | 2.972 (0.942, 9.371) | 0.048 |
YES | 68.750 | ||||
Coagulation disorders | NO | 80.951 | 0.196 | 2.299 (0.622, 8.496) | 0.212 |
YES | 70.308 | ||||
Location code | C18.0 | 77.833 | 0.728 | 0.873 (0.572, 1.330) | 0.526 |
C18.2 | 77.550 | ||||
C18.3 | 82.788 | ||||
Preoperative diagnosis | H | 80.889 | 0.109 | 2.601 (0.751, 9.002) | 0.131 |
O | 81.390 | ||||
P | 61.889 | ||||
Intraoperative complications | NO | 79.879 | 0.497 | 1.988 (0.258, 15.482) | 0.508 |
YES | 70.750 | ||||
Septic status | NO | 82.629 | 0.000 | 12.186 (3.631, 40.895) | 0.000 |
YES | 33.000 | ||||
Interval-interventions | <12 h | 77.881 | 0.708 | 0.944 (0.506, 1.762) | 0.857 |
12–24 h | 84.563 | ||||
>24 h | 79.135 | ||||
Scar abdomen | NO | 81.718 | 0.167 | 2.191 (0.695, 6.906) | 0.181 |
YES | 72.917 | ||||
Operation type | 1 | 61.000 | 0.240 | 0.599 (0.323, 1.110) | 0.103 |
3 | 73.714 | ||||
4 | 81.986 | ||||
Associated maneuvers | - | 82.436 | 0.077 | 0.292 (0.061, 1.407) | 0.125 |
Major | 65.900 | ||||
Minor | 66.143 | ||||
Other organ invasion | NO | 78.613 | 0.465 | 0.476 (0.061, 3.690) | 0.478 |
YES | 84.200 | ||||
Metastases | NO | 80.958 | 0.393 | 1.673 (0.504, 5.561) | 0.401 |
YES | 74.913 | ||||
Colon preparation | NO | 57.200 | 0.053 | 0.252 (0.055, 1.150) | 0.075 |
YES | 80.733 | ||||
Scheme type | 1 | 83.063 | 0.602 | 1.378 (0.776, 2.446) | 0.274 |
2 | 75.357 | ||||
3 | 78.143 | ||||
4 | 72.200 | ||||
Number of hospitalization days | <15 days | 74.316 | 0.147 | 0.440 (0.140, 1.386) | 0.161 |
≥15 days | 82.947 |
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Mihailov, R.; Dima, C.; Constantin, B.G.; Dimofte, F.; Craescu, M.; Moroianu, L.; Candussi, L.I.; Lutenco, V.; Mihailov, O.M.; Lutenco, V. Prognostic Factors of Postoperative Mortality in Patients with Complicated Right Colon Cancer. Life 2025, 15, 350. https://doi.org/10.3390/life15030350
Mihailov R, Dima C, Constantin BG, Dimofte F, Craescu M, Moroianu L, Candussi LI, Lutenco V, Mihailov OM, Lutenco V. Prognostic Factors of Postoperative Mortality in Patients with Complicated Right Colon Cancer. Life. 2025; 15(3):350. https://doi.org/10.3390/life15030350
Chicago/Turabian StyleMihailov, Raul, Corina Dima, Bianca Georgiana Constantin, Florentin Dimofte, Mihaela Craescu, Lavinia Moroianu, Laura Iuliana Candussi, Virginia Lutenco, Oana Mariana Mihailov, and Valerii Lutenco. 2025. "Prognostic Factors of Postoperative Mortality in Patients with Complicated Right Colon Cancer" Life 15, no. 3: 350. https://doi.org/10.3390/life15030350
APA StyleMihailov, R., Dima, C., Constantin, B. G., Dimofte, F., Craescu, M., Moroianu, L., Candussi, L. I., Lutenco, V., Mihailov, O. M., & Lutenco, V. (2025). Prognostic Factors of Postoperative Mortality in Patients with Complicated Right Colon Cancer. Life, 15(3), 350. https://doi.org/10.3390/life15030350