Circulating miRNA-195-5p and -451a in Patients with Acute Hemorrhagic Stroke in Emergency Department
Abstract
:1. Introduction
2. Materials and Methods
2.1. Selection of Participants
2.2. Interventions
2.3. miRNA Isolation and Real-Time Reverse Transcription (qRT-PCR)
2.4. Serum VEGF-A ELISA Assay
2.5. Outcomes
2.6. Statistical Analysis
3. Results
3.1. Characteristics of Study Subjects
3.2. Circulating miRNA-195-5p in ICH and AIS Patients
3.3. Circulating miRNA-451a in ICH and AIS Patients
3.4. Serum VEGF-A in ICH and AIS Patients
3.5. Correlation between Circulating miRNAs and VEGF-A Serum Levels
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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C | ICH | AIS | p Value | |
---|---|---|---|---|
N (M) | 21 (10) | 21 (11) | 20 (9) | ns |
Age (years) | 69 ± 2 | 68 ± 3 | 73 ± 5 | ns |
BMI (kg/m2) | 27 ± 2 | 25 ± 5 | 26 ± 4 | ns |
SBP (mmHg) | 142 ± 6 | 141 ± 7 | 139 ± 5 | ns |
DBP (mmHg) | 81 ± 2 | 85 ± 5 | 82 ± 3 | ns |
Hypertension (%) | 9 (43) | 11 (52) | 9 (45) | ns |
Smoking (%) | (25) | (35) | (35) | ns |
Hyperlipidemia (%) | (40) | (45) | (50) | ns |
NIHSS score | - | 15 ± 1.4 | 16 ± 1.6 | ns * |
Modified Rankin scale | - | 3.7 ± 0.4 | 3.5 ± 0.3 | ns * |
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Giordano, M.; Trotta, M.C.; Ciarambino, T.; D’Amico, M.; Schettini, F.; Sisto, A.D.; D’Auria, V.; Voza, A.; Malatino, L.S.; Biolo, G.; et al. Circulating miRNA-195-5p and -451a in Patients with Acute Hemorrhagic Stroke in Emergency Department. Life 2022, 12, 763. https://doi.org/10.3390/life12050763
Giordano M, Trotta MC, Ciarambino T, D’Amico M, Schettini F, Sisto AD, D’Auria V, Voza A, Malatino LS, Biolo G, et al. Circulating miRNA-195-5p and -451a in Patients with Acute Hemorrhagic Stroke in Emergency Department. Life. 2022; 12(5):763. https://doi.org/10.3390/life12050763
Chicago/Turabian StyleGiordano, Mauro, Maria Consiglia Trotta, Tiziana Ciarambino, Michele D’Amico, Federico Schettini, Angela Di Sisto, Valentina D’Auria, Antonio Voza, Lorenzo Salvatore Malatino, Gianni Biolo, and et al. 2022. "Circulating miRNA-195-5p and -451a in Patients with Acute Hemorrhagic Stroke in Emergency Department" Life 12, no. 5: 763. https://doi.org/10.3390/life12050763