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Review

Post-Transcriptional Control in the Regulation of Polyhydroxyalkanoates Synthesis

1
Control of Gene Expression Lab., Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal
2
Associate Laboratory i4HB-Institute for Health and Bioeconomy, School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, Portugal
3
UCIBIO—Applied Molecular Biosciences Unit, Department of Chemistry, School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, Portugal
*
Authors to whom correspondence should be addressed.
Academic Editor: Stéphane D. Lemaire
Life 2021, 11(8), 853; https://doi.org/10.3390/life11080853
Received: 30 July 2021 / Revised: 15 August 2021 / Accepted: 18 August 2021 / Published: 20 August 2021
(This article belongs to the Special Issue Microbial Biopolymers: From Synthesis to Properties and Applications)
The large production of non-degradable petrol-based plastics has become a major global issue due to its environmental pollution. Biopolymers produced by microorganisms such as polyhydroxyalkanoates (PHAs) are gaining potential as a sustainable alternative, but the high cost associated with their industrial production has been a limiting factor. Post-transcriptional regulation is a key step to control gene expression in changing environments and has been reported to play a major role in numerous cellular processes. However, limited reports are available concerning the regulation of PHA accumulation in bacteria, and many essential regulatory factors still need to be identified. Here, we review studies where the synthesis of PHA has been reported to be regulated at the post-transcriptional level, and we analyze the RNA-mediated networks involved. Finally, we discuss the forthcoming research on riboregulation, synthetic, and metabolic engineering which could lead to improved strategies for PHAs synthesis in industrial production, thereby reducing the costs currently associated with this procedure. View Full-Text
Keywords: polyhydroxyalkanoates; mcl-PHA; scl-PHA; post-transcriptional regulation; riboregulation; small non-coding RNAs polyhydroxyalkanoates; mcl-PHA; scl-PHA; post-transcriptional regulation; riboregulation; small non-coding RNAs
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MDPI and ACS Style

Peregrina, A.; Martins-Lourenço, J.; Freitas, F.; Reis, M.A.M.; Arraiano, C.M. Post-Transcriptional Control in the Regulation of Polyhydroxyalkanoates Synthesis. Life 2021, 11, 853. https://doi.org/10.3390/life11080853

AMA Style

Peregrina A, Martins-Lourenço J, Freitas F, Reis MAM, Arraiano CM. Post-Transcriptional Control in the Regulation of Polyhydroxyalkanoates Synthesis. Life. 2021; 11(8):853. https://doi.org/10.3390/life11080853

Chicago/Turabian Style

Peregrina, Alexandra, João Martins-Lourenço, Filomena Freitas, Maria A.M. Reis, and Cecília M. Arraiano 2021. "Post-Transcriptional Control in the Regulation of Polyhydroxyalkanoates Synthesis" Life 11, no. 8: 853. https://doi.org/10.3390/life11080853

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