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Potential Effects of Nutraceuticals in Retinopathy of Prematurity

Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Department of Ophthalmology, Charité–University Medicine Berlin, 10117 Berlin, Germany
Department of Ophthalmology, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming 650500, China
Authors to whom correspondence should be addressed.
Life 2021, 11(2), 79;
Received: 2 November 2020 / Revised: 15 January 2021 / Accepted: 16 January 2021 / Published: 22 January 2021
(This article belongs to the Collection Retinal Disease and Metabolism)
Retinopathy of prematurity (ROP), the most common cause of childhood blindness, is a hypoxia-induced eye disease characterized by retinal neovascularization. In the normal retina, a well-organized vascular network provides oxygen and nutrients as energy sources to maintain a normal visual function; however, it is disrupted when pathological angiogenesis is induced in ROP patients. Under hypoxia, inadequate oxygen and energy supply lead to oxidative stress and stimulate neovasculature formation as well as affecting the function of photoreceptors. In order to meet the metabolic needs in the developing retina, protection against abnormal vascular formation is one way to manage ROP. Although current treatments provide beneficial effects in reducing the severity of ROP, these invasive therapies may also induce life-long consequences such as systemic structural and functional complications as well as neurodevelopment disruption in the developing infants. Nutritional supplements for the newborns are a novel concept for restoring energy supply by protecting the retinal vasculature and may lead to better ROP management. Nutraceuticals are provided in a non-invasive manner without the developmental side effects associated with current treatments. These nutraceuticals have been investigated through various in vitro and in vivo methods and are indicated to protect retinal vasculature. Here, we reviewed and discussed how the use of these nutraceuticals may be beneficial in ROP prevention and management. View Full-Text
Keywords: carotenoid; flavonoid; herbal extracts; inflammation; oil; preterm; retinal neovascularization; VEGF carotenoid; flavonoid; herbal extracts; inflammation; oil; preterm; retinal neovascularization; VEGF
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MDPI and ACS Style

Tsang, J.K.W.; Wolf, S.A.; Pompoes, I.M.; Joussen, A.M.; Lam, W.C.; Yang, D.; Lo, A.C.Y. Potential Effects of Nutraceuticals in Retinopathy of Prematurity. Life 2021, 11, 79.

AMA Style

Tsang JKW, Wolf SA, Pompoes IM, Joussen AM, Lam WC, Yang D, Lo ACY. Potential Effects of Nutraceuticals in Retinopathy of Prematurity. Life. 2021; 11(2):79.

Chicago/Turabian Style

Tsang, Jessica K. W., Susanne A. Wolf, Inga M. Pompoes, Antonia M. Joussen, Wai Ching Lam, Di Yang, and Amy C. Y. Lo. 2021. "Potential Effects of Nutraceuticals in Retinopathy of Prematurity" Life 11, no. 2: 79.

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