A Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study
Abstract
:1. Introduction
2. Materials and Method
2.1. Study Area
2.2. Study Design
2.3. Sample Collection
2.4. Biochemical Analyses
2.5. Statistical Analysis
3. Results
3.1. Characteristics of LC and HC Groups
3.2. Levels of Serum Analytes in LC and HC Groups
3.3. Levels of Serum Analytes in LC, LRR and HRR Groups
3.4. Diagnostic Ability of Serum Biomarker for LC Risk in High Level Environmental Radon Areas
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristics. | LC (n = 75) | HC | ||
---|---|---|---|---|
LRR (n = 25) | HRR (n = 50) | Total (n = 75) | ||
Age in years, mean (SD) | 60.3 (10.8) | 61.2 (7.1) | 58.8 (8.8) | 59.6.(8.3) |
Gender | ||||
Male | 38 | 15 | 23 | 38 |
Female | 37 | 10 | 27 | 37 |
Biomarker | Sensitivity (%) | Specificity (%) | AUC |
---|---|---|---|
CEA | 57.3 | 98 | 0.7821 |
Cyfra21-1 | 58.6 | 94 | 0.7968 |
IL-8 | 48 | 76 | 0.6063 |
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Autsavapromporn, N.; Klunklin, P.; Chitapanarux, I.; Jaikang, C.; Chewaskulyong, B.; Sripan, P.; Hosoda, M.; Tokonami, S. A Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study. Life 2021, 11, 1273. https://doi.org/10.3390/life11111273
Autsavapromporn N, Klunklin P, Chitapanarux I, Jaikang C, Chewaskulyong B, Sripan P, Hosoda M, Tokonami S. A Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study. Life. 2021; 11(11):1273. https://doi.org/10.3390/life11111273
Chicago/Turabian StyleAutsavapromporn, Narongchai, Pitchayaponne Klunklin, Imjai Chitapanarux, Churdsak Jaikang, Busyamas Chewaskulyong, Patumrat Sripan, Masahiro Hosoda, and Shinji Tokonami. 2021. "A Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study" Life 11, no. 11: 1273. https://doi.org/10.3390/life11111273