Nocturnal Lagophthalmos and Sleep Quality in Patients with Dry Eye Disease
Abstract
1. Introduction
2. Methods
2.1. Patient Recruitment
2.2. Ethics Statements
2.3. Questionnaire
2.4. Data and Statistical Analyses
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Question | Possible Answers |
---|---|
1. Height | m |
2. Weight | kg |
Dry Eye | |
D3. “How often do you feel dryness in your eye?” | 1: constantly, 2: sometimes, 3: rarely, 4: never |
D4. “How often do you have a sensation of a foreign body in your eye?” | 1: constantly, 2: sometimes, 3: rarely, 4: never |
D5. “Have you been diagnosed as having DED?” | 1: yes, 2: no |
D6. “Do you have a dry mouth?” | 1: constantly, 2: sometimes; 3: rarely, 4: never |
Sleep | |
S7. “How would you rate the quality of your sleep?” | 1: great, 2: good, 3: average, 4: not good, 5: poorly |
S8. “At what time do you get up during weekdays?” | Time |
S9. “At what time do you go to bed during weekdays?” | Time |
S10. “How long does it take you to fall asleep after you go to bed?” | Duration (minutes) |
S11. “Are your eyes open during sleep?” | 1: yes, 2: no, 3: not sure |
Morning eye symptom | |
M12. “Do you wake up to eye pain during sleep?” | 1: never, 2: once a week, 3: twice to four times a week, 4: every night |
M13. “How do your eyes feel when you wake up?” | 1: good, 2: not good, 3: have difficulty opening, 4: feel foreign body sensation, 5: feel pain, 6: eye discharge, 7: lacrimation, 8: dry, 9: sensitive to light, 10: others, multiple answers allowed |
M14. “Do you take eye drops after waking or for sleeping?” | 1: at waking, 2: at sleeping, 3: neither |
Lifestyle | |
L15. “How often do you have a night shift?” | Time per month |
L16. “How long do you spend outside during daytime?” | 1: less than one h, 2: 1 h, 3: 2 h, 4: 3 h, 5: 4 h, 6: 5 h, 7: 6 h, 8: 7 h, 9: 8 h, 10: 9 h, 11: more than 10 h |
L17. “How would you rate your happiness?” | 7–1: happiest–unhappiest |
NL (+) n = 90 (5%) | NL (−) n = 1174 (59%) | p-Value | |
---|---|---|---|
Age (years) | 40.5 ± 13.8 | 44.8 ± 13.9 | 0.004 * |
Gender (male/female) | 42/48 | 574/600 | 0.68 |
BMI | 22.5 ± 3.8 | 22.2 ± 3.7 | 0.50 |
Sleep Parameters | |||
Sleep latency (minutes) | 26.4 ± 27.5 | 22.3 ± 22.1 | 0.10 |
Sleep efficacy (%) | 93.3 ± 6.5 | 94.3 ± 5.7 | 0.13 |
Sleep duration (minutes) | 370 ± 64 | 377 ± 73 | 0.37 |
Subjective sleep quality | 2.83 ± 1.07 | 2.63 ± 1.02 | 0.07 |
Subjective happiness | 4.2 ± 1.4 | 4.4 ± 1.5 | 0.29 |
Outdoor time (hours) | 3.5 ± 2.3 | 3.1 ± 2.3 | 0.16 |
Night shift (times/month) | 1.76 ± 5.4 | 0.70 ± 0.5 | 0.002 * |
Number of symptoms of eyes upon waking | 1.09 ± 1.3 | 0.71 ± 0.92 | <0.001 * |
Symptoms in Detail | |||
None | 39 (43.3%) | 592 (50.5%) | 0.189 |
Difficulty opening eyes | 13 (14.4%) | 63 | <0.001 ** |
Foreign body sensation | 18 | 95 | <0.001 ** |
Eye pain | 6 | 29 | 0.020 ** |
Discharge | 22 | 276 | 0.85 |
Tears | 8 | 57 | 0.10 |
Dryness | 8 | 103 | 0.97 |
Photophobia | 3 | 98 | 0.09 |
DED (+) n = 890 (45%) | DED (−) n = 1110 (56%) | p-Value | |
---|---|---|---|
Age (years) | 44.0 ± 13.8 | 45.2 ± 13.9 | 0.05 |
Gender (male/female) | 359/531 | 641/469 | <0.001 ** |
BMI (kg/m2) | 22.2 ± 4.0 | 22.4 ± 3.7 | 0.26 |
Sleep Parameters | |||
Sleep latency (minutes) | 25.5 ± 24.6 | 21.6 ± 21.3 | <0.001 * |
Sleep efficacy (%) | 93.4 ± 6.5 | 94.5 ± 5.7 | <0.001 * |
Sleep duration (minutes) | 368 ± 74 | 377 ± 76 | 0.008 * |
Subjective sleep quality | 2.91 ± 1.02 | 2.60 ± 1.04 | <0.001 *** |
Subjective happiness | 4.2 ± 1.5 | 4.3 ± 1.5 | 0.04 * |
Outdoor activity time (hours) | 3.3 ± 2.5 | 3.1 ± 2.4 | 0.05 |
Night shift (times/month) | 0.96 ± 3.2 | 0.63 ± 2.9 | 0.02 * |
Nocturnal lagophthalmos | 49 (5.4%) | 41(3.7%) | 0.007 * |
Dryness of mouth | 398 (44.7%) | 415 (37.4%) | 0.001 ** |
Number of symptoms of eyes upon waking | 1.24 ± 1.1 | 0.47 ± 0.43 | <0.001 * |
Symptoms in Detail | |||
None | 225 (24.7%) | 687 (75.3%) | <0.001 ** |
Difficulty opening eyes | 90 | 36 | <0.001 ** |
Foreign body sensation | 171 | 32 | <0.001 ** |
Eye pain | 14 | 49 | <0.001 ** |
Discharge | 301 | 204 | <0.001 ** |
Tears | 69 | 45 | <0.001 ** |
Dryness | 145 | 41 | <0.001 ** |
Photophobia | 102 | 56 | <0.001 ** |
Variables | Odds Ratio | 95% Confidence Interval | p-Value |
---|---|---|---|
Age # | 0.97 | 0.96–0.99 | 0.005 * |
Gender (1: male, 0: female) # | 0.94 | 0.58–1.35 | 0.78 |
BMI (kg/m2) | 1.03 | 0.97–1.09 | 0.30 |
DED (1: (+), 0: (−)) | 1.75 | 1.12–2.71 | 0.01 * |
Sleep parameters | |||
Sleep latency (minutes) | 1.00 | 0.99–1.01 | 0.55 |
Sleep efficacy (%) | 1.00 | 0.96–1.04 | 0.94 |
Sleep duration (minutes) | 1.00 | 0.99–1.00 | 0.11 |
Subjective sleep quality | 1.16 | 0.94–1.43 | 0.16 |
Subjective happiness | 1.07 | 0.92–1.26 | 0.35 |
Outdoor time | 1.06 | 0.98–1.15 | 0.16 |
Night shift (times/month) | 0.98 | 0.91–1.06 | 0.62 |
Dryness of mouth (1: (+), 0: (−)) | 1.00 | 0.65–1.56 | 0.99 |
Number of symptoms of eyes upon awakening | 1.23 | 1.03–1.47 | 0.04 * |
Symptoms in detail | |||
Difficulty opening eyes (1: (+), 0: (−)) | 1.99 | 1.00–3.95 | 0.049 * |
Foreign body sensation (1: (+), 0: (−)) | 1.00 | 0.47–2.14 | 1.00 |
Eye pain (1: (+), 0: (−)) | 2.71 | 1.09–6.75 | 0.03 * |
Discharge (1: (+), 0: (−)) | 1.37 | 0.85–2.19 | 0.20 |
Tears (1: (+), 0: (−)) | 0.82 | 0.29–2.30 | 0.70 |
Dryness (1: (+), 0: (−)) | 1.73 | 0.94–3.19 | 0.08 |
Photophobia (1: (+), 0: (−)) | 1.11 | 0.52–2.37 | 0.80 |
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Takahashi, A.; Negishi, K.; Ayaki, M.; Uchino, M.; Tsubota, K. Nocturnal Lagophthalmos and Sleep Quality in Patients with Dry Eye Disease. Life 2020, 10, 105. https://doi.org/10.3390/life10070105
Takahashi A, Negishi K, Ayaki M, Uchino M, Tsubota K. Nocturnal Lagophthalmos and Sleep Quality in Patients with Dry Eye Disease. Life. 2020; 10(7):105. https://doi.org/10.3390/life10070105
Chicago/Turabian StyleTakahashi, Aya, Kazuno Negishi, Masahiko Ayaki, Miki Uchino, and Kazuo Tsubota. 2020. "Nocturnal Lagophthalmos and Sleep Quality in Patients with Dry Eye Disease" Life 10, no. 7: 105. https://doi.org/10.3390/life10070105
APA StyleTakahashi, A., Negishi, K., Ayaki, M., Uchino, M., & Tsubota, K. (2020). Nocturnal Lagophthalmos and Sleep Quality in Patients with Dry Eye Disease. Life, 10(7), 105. https://doi.org/10.3390/life10070105