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Article

Transcriptome Analysis of the Toxic Effects of Amisulbrom and Isoflucypram on Zebrafish (Danio rerio) Larvae

by 1,*, 2, 3 and 1
1
National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution of Life and Environmental Science, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China
2
Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China
3
Wenzhou Key Laboratory of Sanitary Microbiology, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China
*
Author to whom correspondence should be addressed.
Academic Editors: Nicoletta Ademollo, Jasmin Rauseo, Luisa Patrolecco and Francesca Spataro
Water 2022, 14(2), 272; https://doi.org/10.3390/w14020272
Received: 14 December 2021 / Revised: 13 January 2022 / Accepted: 14 January 2022 / Published: 17 January 2022
Fungicides are frequently detected in the water bodies, however, the adverse effects of these fungicides on aquatic lives remain limited. To better understand the adverse effects of amisulbrom (AML) and isoflucypram (ISO) on embryogenesis, zebrafish embryos were exposed to two different fungicides, 0.75 μM amisulbrom (AML) and 2.5 μM isoflucypram (ISO), for 72 h. Transcriptome sequencing was employed to identify differentially expressed genes (DEGs) after AML and ISO exposure. A total of 571 and 3471 DEGs were detected between the libraries of the two fungicides-treated groups and the control, respectively. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that PPAR signaling pathway, phototransduction, ribosome and p53 signaling pathway were significantly enriched in response to both AML and ISO stress. Moreover, a number of DEGs involved in tyrosine metabolism, phagosome pathway, cell cycle pathway, extracellular matrix (ECM) receptor interaction pathway, and arginine and proline metabolism were specially enriched after exposure to AML; a number of DEGs involved in notch signaling pathway, drug metabolism, alanine, aspartate and glutamate metabolism, amino-acyl−tRNA biosynthesis, and protein processing in endoplasmic reticulum were significantly enriched after exposure to ISO. These results provide novel insights into the toxicological mechanisms underlying fish’s responses to fungicides. View Full-Text
Keywords: amisulbrom; isoflucypram; zebrafish; larvae; gene expression amisulbrom; isoflucypram; zebrafish; larvae; gene expression
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MDPI and ACS Style

Xiao, P.; Li, W.; Lu, J.; Zhang, H. Transcriptome Analysis of the Toxic Effects of Amisulbrom and Isoflucypram on Zebrafish (Danio rerio) Larvae. Water 2022, 14, 272. https://doi.org/10.3390/w14020272

AMA Style

Xiao P, Li W, Lu J, Zhang H. Transcriptome Analysis of the Toxic Effects of Amisulbrom and Isoflucypram on Zebrafish (Danio rerio) Larvae. Water. 2022; 14(2):272. https://doi.org/10.3390/w14020272

Chicago/Turabian Style

Xiao, Peng, Wenhua Li, Jinfang Lu, and He Zhang. 2022. "Transcriptome Analysis of the Toxic Effects of Amisulbrom and Isoflucypram on Zebrafish (Danio rerio) Larvae" Water 14, no. 2: 272. https://doi.org/10.3390/w14020272

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