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Genome-Wide Identification and Analysis of Arabidopsis Sodium Proton Antiporter (NHX) and Human Sodium Proton Exchanger (NHE) Homologs in Sorghum bicolor

1
Department of Genetics, Osmania University, Hyderabad 500 007, India
2
Centre for Biotechnology, Institute of Science & Technology, JNT University, Hyderabad 500 085, India
3
Department of Biological Sciences, Florida A&M University, Tallahassee, FL 32307, USA
4
Center of Excellence in Genomics & Systems Biology, International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Patancheru, Hyderabad 502 324, India
5
IITA-Kenya c/o International Livestock Research Institute (ILRI), PO Box 30709, Nairobi 00100, Kenya
6
Ottawa University, Ottawa, KS 66067, USA
7
Genomix CARL Pvt. Ltd. Rayalapuram Road, Pulivendula, 516 390, Kadapa, Andhra Pradesh, India
*
Author to whom correspondence should be addressed.
Genes 2018, 9(5), 236; https://doi.org/10.3390/genes9050236
Received: 13 March 2018 / Revised: 24 April 2018 / Accepted: 24 April 2018 / Published: 3 May 2018
(This article belongs to the Section Plant Genetics and Genomics)
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Abstract

Na+ transporters play an important role during salt stress and development. The present study is aimed at genome-wide identification, in silico analysis of sodium-proton antiporter (NHX) and sodium-proton exchanger (NHE)-type transporters in Sorghum bicolor and their expression patterns under varied abiotic stress conditions. In Sorghum, seven NHX and nine NHE homologs were identified. Amiloride (a known inhibitor of Na+/H+ exchanger activity) binding motif was noticed in both types of the transporters. Chromosome 2 was found to be a hotspot region with five sodium transporters. Phylogenetic analysis inferred six ortholog and three paralog groups. To gain an insight into functional divergence of SbNHX/NHE transporters, real-time gene expression was performed under salt, drought, heat, and cold stresses in embryo, root, stem, and leaf tissues. Expression patterns revealed that both SbNHXs and SbNHEs are responsive either to single or multiple abiotic stresses. The predicted protein–protein interaction networks revealed that only SbNHX7 is involved in the calcineurin B-like proteins (CBL)- CBL interacting protein kinases (CIPK) pathway. The study provides insights into the functional divergence of SbNHX/NHE transporter genes with tissue specific expressions in Sorghum under different abiotic stress conditions. View Full-Text
Keywords: abiotic stress; amiloride; CBL-CIPK pathway; sodium-proton exchanger; sodium-proton antiporter; Sorghum bicolor abiotic stress; amiloride; CBL-CIPK pathway; sodium-proton exchanger; sodium-proton antiporter; Sorghum bicolor
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Hima Kumari, P.; Anil Kumar, S.; Ramesh, K.; Sudhakar Reddy, P.; Nagaraju, M.; Bhanu Prakash, A.; Shah, T.; Henderson, A.; Srivastava, R.K.; Rajasheker, G.; Chitikineni, A.; Varshney, R.K.; Rathnagiri, P.; Lakshmi Narasu, M.; Kavi Kishor, P.B. Genome-Wide Identification and Analysis of Arabidopsis Sodium Proton Antiporter (NHX) and Human Sodium Proton Exchanger (NHE) Homologs in Sorghum bicolor. Genes 2018, 9, 236.

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