Next Article in Journal
MHC-Dependent Mate Selection within 872 Spousal Pairs of European Ancestry from the Health and Retirement Study
Previous Article in Journal
Applications of Probe Capture Enrichment Next Generation Sequencing for Whole Mitochondrial Genome and 426 Nuclear SNPs for Forensically Challenging Samples
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
Genes
Volume 9
Issue 1
10.3390/genes9010056
genes-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement question_answer thumb_up
...
textsms
...
Article

Identification of a Common Different Gene Expression Signature in Ischemic Cardiomyopathy

by
Yana Li
1,†,
Qiu Jiang
1,†,
Zhiwen Ding
1,†,
Guijian Liu
1,
Peng Yu
1,
Guoliang Jiang
1,
Ziqing Yu
1,
Chunjie Yang
1,
Juying Qian
1,
Hong Jiang
1,2,* and
Yunzeng Zou
1,3,*
1
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, 180 Fenglin Road, Shanghai 200032, China
2
Shanghai Institute of clinical bioinformatics, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China
3
Institutes of Biomedical Sciences, Fudan University, 130 Dong’an Road, Shanghai 200032, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Genes 2018, 9(1), 56; https://doi.org/10.3390/genes9010056
Received: 20 December 2017 / Revised: 9 January 2018 / Accepted: 16 January 2018 / Published: 22 January 2018
(This article belongs to the Section Human Genomics and Genetic Diseases)
View Full-Text Download PDF
Browse Figures

Abstract

The molecular mechanisms underlying the development of ischemic cardiomyopathy (ICM) remain poorly understood. Gene expression profiling is helpful to discover the molecular changes taking place in ICM. The aim of this study was to identify the genes that are significantly changed during the development of heart failure caused by ICM. The differentially expressed genes (DEGs) were identified from 162 control samples and 227 ICM patients. PANTHER was used to perform gene ontology (GO), and Reactome for pathway enrichment analysis. A protein–protein interaction network was established using STRING and Cytoscape. A further validation was performed by real-time polymerase chain reaction (RT-PCR). A total of 255 common DEGs was found. Gene ontology, pathway enrichment, and protein–protein interaction analysis showed that nucleic acid-binding proteins, enzymes, and transcription factors accounted for a great part of the DEGs, while immune system signaling and cytokine signaling displayed the most significant changes. Furthermore, seven hub genes and nine transcription factors were identified. Interestingly, the top five upregulated DEGs were located on chromosome Y, and four of the top five downregulated DEGs were involved in immune and inflammation signaling. Further, the top DEGs were validated by RT-PCR in human samples. Our study explored the possible molecular mechanisms of heart failure caused by ischemic heart disease. View Full-Text
Keywords: ischemic cardiomyopathy; microarrays; bioinformatical analysis ischemic cardiomyopathy; microarrays; bioinformatical analysis
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Supplementary Material

SciFeed

Share and Cite

MDPI and ACS Style

Li, Y.; Jiang, Q.; Ding, Z.; Liu, G.; Yu, P.; Jiang, G.; Yu, Z.; Yang, C.; Qian, J.; Jiang, H.; Zou, Y. Identification of a Common Different Gene Expression Signature in Ischemic Cardiomyopathy. Genes 2018, 9, 56. https://doi.org/10.3390/genes9010056

AMA Style

Li Y, Jiang Q, Ding Z, Liu G, Yu P, Jiang G, Yu Z, Yang C, Qian J, Jiang H, Zou Y. Identification of a Common Different Gene Expression Signature in Ischemic Cardiomyopathy. Genes. 2018; 9(1):56. https://doi.org/10.3390/genes9010056

Chicago/Turabian Style

Li, Yana, Qiu Jiang, Zhiwen Ding, Guijian Liu, Peng Yu, Guoliang Jiang, Ziqing Yu, Chunjie Yang, Juying Qian, Hong Jiang, and Yunzeng Zou. 2018. "Identification of a Common Different Gene Expression Signature in Ischemic Cardiomyopathy" Genes 9, no. 1: 56. https://doi.org/10.3390/genes9010056

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Back to TopTop