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Genes 2017, 8(1), 36;

Familial Lung Cancer: A Brief History from the Earliest Work to the Most Recent Studies

National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38103, USA
Mayo Clinic, Rochester, MN 55904, USA
Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Department of Medicine, University of Toledo Dana Cancer Center, Toledo, OH 43604, USA
Geisel School of Medicine, Dartmouth College, Lebanon, NH 03766, USA
Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53202, USA
Karmanos Cancer Institute, Wayne State University, Detroit, MI 48226, USA
Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45202, USA
Author to whom correspondence should be addressed.
Academic Editor: J. Peter W. Young
Received: 28 October 2016 / Revised: 29 December 2016 / Accepted: 11 January 2017 / Published: 17 January 2017
(This article belongs to the Special Issue Cancer Genetics)
Full-Text   |   PDF [225 KB, uploaded 17 January 2017]


Lung cancer is the deadliest cancer in the United States, killing roughly one of four cancer patients in 2016. While it is well-established that lung cancer is caused primarily by environmental effects (particularly tobacco smoking), there is evidence for genetic susceptibility. Lung cancer has been shown to aggregate in families, and segregation analyses have hypothesized a major susceptibility locus for the disease. Genetic association studies have provided strong evidence for common risk variants of small-to-moderate effect. Rare and highly penetrant alleles have been identified by linkage studies, including on 6q23–25. Though not common, some germline mutations have also been identified via sequencing studies. Ongoing genomics studies aim to identify additional high penetrance germline susceptibility alleles for this deadly disease. View Full-Text
Keywords: lung cancer; susceptibility; major gene; linkage; family studies lung cancer; susceptibility; major gene; linkage; family studies
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Musolf, A.M.; Simpson, C.L.; de Andrade, M.; Mandal, D.; Gaba, C.; Yang, P.; Li, Y.; You, M.; Kupert, E.Y.; Anderson, M.W.; Schwartz, A.G.; Pinney, S.M.; Amos, C.I.; Bailey-Wilson, J.E. Familial Lung Cancer: A Brief History from the Earliest Work to the Most Recent Studies. Genes 2017, 8, 36.

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