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Genes 2016, 7(7), 36;

Effect of Genetic Diversity in Swine Leukocyte Antigen-DRA Gene on Piglet Diarrhea

College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China
Ruzhou Animal Husbandry Bureau, Ruzhou 467500, China
College of Life Science and Engineering, Northwest University for Nationalities, Lanzhou 730070, China
Gansu Research Center for Swine Production Engineering and Technology, Lanzhou 730070, China
Author to whom correspondence should be addressed.
Academic Editor: Paolo Cinelli
Received: 6 March 2016 / Revised: 4 July 2016 / Accepted: 6 July 2016 / Published: 15 July 2016
(This article belongs to the Section Molecular Genetics and Genomics)
Full-Text   |   PDF [816 KB, uploaded 15 July 2016]   |  


The swine leukocyte antigens (SLAs) are the multigene families related to immune responses. Little is known about the effect of the DRA gene on diarrheal disease. This study reported the genetic diversity of the DRA gene in exons 1, 3 and 4 in 290 Chinese Yantai black pigs. No variation was identified in exon 3. In exon 1, three genotypes and two alleles were identified, generated by two single nucleotide polymorphisms (SNPs). In exon 4, there were eight genotypes and five alleles containing seven SNPs were detected with four SNPs being novel SNPs. The low polymorphism found in swine DRA is consistent with the concept that the DRA gene is highly conserved among all mammalian species. Statistical analyses indicated that the genotypes of exon 1 were not significantly associated with piglet diarrhea (p > 0.05); however, genotypes C4C4 (1.80 ± 0.33) and A4E4 (1.66 ± 0.25) of exon 4 were significantly susceptible to diarrhea (p < 0.01). These indicate that the particular genotypes of the DRA gene are susceptible to diarrheal disease, which provides valuable information for disease-resistance breeding in swine. View Full-Text
Keywords: SLA-DRA; genetic diversity; PCR-SSCP; diarrhea; swine SLA-DRA; genetic diversity; PCR-SSCP; diarrhea; swine

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Huang, X.; Yang, Q.; Yuan, J.; Liu, L.; Sun, W.; Jiang, Y.; Zhao, S.; Zhang, S.; Huang, W.; Gun, S. Effect of Genetic Diversity in Swine Leukocyte Antigen-DRA Gene on Piglet Diarrhea. Genes 2016, 7, 36.

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