The Cell Killing Mechanisms of Hydroxyurea
AbstractHydroxyurea is a well-established inhibitor of ribonucleotide reductase that has a long history of scientific interest and clinical use for the treatment of neoplastic and non-neoplastic diseases. It is currently the staple drug for the management of sickle cell anemia and chronic myeloproliferative disorders. Due to its reversible inhibitory effect on DNA replication in various organisms, hydroxyurea is also commonly used in laboratories for cell cycle synchronization or generating replication stress. However, incubation with high concentrations or prolonged treatment with low doses of hydroxyurea can result in cell death and the DNA damage generated at arrested replication forks is generally believed to be the direct cause. Recent studies in multiple model organisms have shown that oxidative stress and several other mechanisms may contribute to the majority of the cytotoxic effect of hydroxyurea. This review aims to summarize the progress in our understanding of the cell-killing mechanisms of hydroxyurea, which may provide new insights towards the improvement of chemotherapies that employ this agent. View Full-Text
A printed edition of this Special Issue is available here.
Share & Cite This Article
Singh, A.; Xu, Y.-J. The Cell Killing Mechanisms of Hydroxyurea. Genes 2016, 7, 99.
Singh A, Xu Y-J. The Cell Killing Mechanisms of Hydroxyurea. Genes. 2016; 7(11):99.Chicago/Turabian Style
Singh, Amanpreet; Xu, Yong-Jie. 2016. "The Cell Killing Mechanisms of Hydroxyurea." Genes 7, no. 11: 99.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.