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The Human Transcriptome: An Unfinished Story

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Genes 2012, 3(3), 344-360;
Received: 15 May 2012 / Revised: 14 June 2012 / Accepted: 25 June 2012 / Published: 29 June 2012
(This article belongs to the Special Issue Junk DNA' is not Junk)
Despite recent technological advances, the study of the human transcriptome is still in its early stages. Here we provide an overview of the complex human transcriptomic landscape, present the bioinformatics challenges posed by the vast quantities of transcriptomic data, and discuss some of the studies that have tried to determine how much of the human genome is transcribed. Recent evidence has suggested that more than 90% of the human genome is transcribed into RNA. However, this view has been strongly contested by groups of scientists who argued that many of the observed transcripts are simply the result of transcriptional noise. In this review, we conclude that the full extent of transcription remains an open question that will not be fully addressed until we decipher the complete range and biological diversity of the transcribed genomic sequences. View Full-Text
Keywords: transcriptome; pervasive transcription; RNA-seq; mRNA; ncRNA transcriptome; pervasive transcription; RNA-seq; mRNA; ncRNA
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Pertea, M. The Human Transcriptome: An Unfinished Story. Genes 2012, 3, 344-360.

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Pertea M. The Human Transcriptome: An Unfinished Story. Genes. 2012; 3(3):344-360.

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Pertea, Mihaela. 2012. "The Human Transcriptome: An Unfinished Story" Genes 3, no. 3: 344-360.

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