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A Model of Repetitive-DNA-Organized Chromatin Network of Interphase Chromosomes

Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
The author dedicates this paper to Professor Liangshi Liu.
Genes 2012, 3(1), 167-175; https://doi.org/10.3390/genes3010167
Received: 14 January 2012 / Revised: 21 February 2012 / Accepted: 28 February 2012 / Published: 7 March 2012
(This article belongs to the Special Issue Junk DNA' is not Junk)
During interphase, chromosomes are relatively de-condensed in the nuclear space. Interphase chromosomes are known to occupy nuclear space in a non-random manner (chromosome territory); however, their internal structures are poorly defined. In particular, little is understood about the molecular mechanisms that govern the internal organization of interphase chromosomes. The author recently proposed that pairing (or interaction) of repetitive DNA-containing chromatin regions is a critical driving force that specifies the higher-order organization of eukaryotic chromosomes. Guided by this theoretical framework and published experimental data on the structure of interphase chromosomes and the spatial distribution of repetitive DNA in interphase nuclei, I postulate here a molecular structure of chromatin organization in interphase chromosomes. According to this model, an interphase chromosome is a chromatin mesh (or lattice) that is formed by repeat pairing (RP). The mesh consists of two types of structural components: chromosome nodes and loose chromatin fibers. Chromosome nodes are DNA repeat assemblies (RAs) that are formed via RP, while loose fibers include chromatin loops that radiate from the nodes. Different loops crosslink by RPs and form a large integrated chromatin network. I suggest that the organization of the chromatin network of a given interphase chromosome is intrinsically specified by the distribution of repetitive DNA elements on the linear chromatin. The stability of the organization is governed by the collection of RA-formed nodes, and the dynamics of the organization is driven by the assembling and disassembling of the nodes. View Full-Text
Keywords: repetitive DNA; repetitive element; repetitive sequence; DNA repeat; junk DNA; transposons; chromosome; chromatin repetitive DNA; repetitive element; repetitive sequence; DNA repeat; junk DNA; transposons; chromosome; chromatin
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Tang, S.-J. A Model of Repetitive-DNA-Organized Chromatin Network of Interphase Chromosomes. Genes 2012, 3, 167-175.

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