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Volume 16
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10.3390/genes16080949
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Oxidative Stress and Intestinal Transcriptome Changes in Clostridium perfringens Type A-Caused Enteritis in Deer

by
Meihui Wang
1,†,
Qingyun Guo
2,3,†,
Zhenyu Zhong
2,3,
Qingxun Zhang
2,3,
Yunfang Shan
2,3,
Zhibin Cheng
2,3,
Xiao Wang
4,
Yuping Meng
5,
Yulan Dong
1,* and
Jiade Bai
2,3,*
1
Laboratory of Veterinary Anatomy, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
2
Beijing Milu Ecological Research Center, Beijing 100076, China
3
National Conservation and Research Center for Milu, Beijing 100076, China
4
Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
5
Beijing Acadamy of Science and Technology, Beijing 10089, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Genes 2025, 16(8), 949; https://doi.org/10.3390/genes16080949
Submission received: 9 July 2025 / Revised: 29 July 2025 / Accepted: 6 August 2025 / Published: 11 August 2025
(This article belongs to the Section Animal Genetics and Genomics)
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Abstract

Background: Clostridium perfringens (C. perfringens) type A is a major cause of enteritis in farmed and wild deer populations, leading to significant economic losses in the deer industry. This bacterium produces toxins that damage the intestine. Methods: In this study, we performed transcriptome analysis by establishing an intestinal circulation model of the intestines of fallow deer (Dama Dama) inoculated with C. perfringens type A versus those not inoculated with C. perfringens type A. In a further step, we determined the protein content of immunoinflammation-related molecules by ELISA and the antioxidant capacity of the intestine to investigate the molecular mechanisms of C. perfringens type A-induced enteritis. Results: Transcriptome analysis revealed significant enrichment of pathways related to the haematopoietic system, oxidative stress, the immune system and intestinal tight junctions. Additionally, C. perfringens α-toxin enters the intestine and may be recognized by TLR6, activating the immune system, increasing the secretion of various cytokines and inflammasome components, inducing oxidative stress and damaging the intestine. Conclusions: This study provides a comprehensive transcriptomic basis for understanding the selective differential expression of genes in deer enteritis induced by C. perfringens type A and provides a broader guide for finding therapeutic approaches to deer enteritis.
Keywords: Clostridium perfringens type A; enteritis; oxidative stress; immunity; transcriptome Clostridium perfringens type A; enteritis; oxidative stress; immunity; transcriptome
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MDPI and ACS Style

Wang, M.; Guo, Q.; Zhong, Z.; Zhang, Q.; Shan, Y.; Cheng, Z.; Wang, X.; Meng, Y.; Dong, Y.; Bai, J. Oxidative Stress and Intestinal Transcriptome Changes in Clostridium perfringens Type A-Caused Enteritis in Deer. Genes 2025, 16, 949. https://doi.org/10.3390/genes16080949

AMA Style

Wang M, Guo Q, Zhong Z, Zhang Q, Shan Y, Cheng Z, Wang X, Meng Y, Dong Y, Bai J. Oxidative Stress and Intestinal Transcriptome Changes in Clostridium perfringens Type A-Caused Enteritis in Deer. Genes. 2025; 16(8):949. https://doi.org/10.3390/genes16080949

Chicago/Turabian Style

Wang, Meihui, Qingyun Guo, Zhenyu Zhong, Qingxun Zhang, Yunfang Shan, Zhibin Cheng, Xiao Wang, Yuping Meng, Yulan Dong, and Jiade Bai. 2025. "Oxidative Stress and Intestinal Transcriptome Changes in Clostridium perfringens Type A-Caused Enteritis in Deer" Genes 16, no. 8: 949. https://doi.org/10.3390/genes16080949

APA Style

Wang, M., Guo, Q., Zhong, Z., Zhang, Q., Shan, Y., Cheng, Z., Wang, X., Meng, Y., Dong, Y., & Bai, J. (2025). Oxidative Stress and Intestinal Transcriptome Changes in Clostridium perfringens Type A-Caused Enteritis in Deer. Genes, 16(8), 949. https://doi.org/10.3390/genes16080949

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