Next Article in Journal
Whole Genome Resequencing Helps Study Important Traits in Chickens
Previous Article in Journal
A Comparison of Non-Destructive Visceral Swab and Tissue Biopsy Sampling Methods for Genotyping-by-Sequencing in the Freshwater Mussel Fusconaia askewi
Previous Article in Special Issue
Persistence of Abscisic Acid Analogs in Plants: Chemical Control of Plant Growth and Physiology
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Genes
Volume 14
Issue 6
10.3390/genes14061199
genes-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Histone Deacetylases HD2A and HD2B Undergo Feedback Regulation by ABA and Modulate Drought Tolerance via Mediating ABA-Induced Transcriptional Repression

by
Yongtao Han
1,
Amira Haouel
1,
Elisabeth Georgii
1,
Santiago Priego-Cubero
2,
Christoph J. Wurm
1,
Daniel Hemmler
3,
Philippe Schmitt-Kopplin
3,
Claude Becker
2,
Jörg Durner
1,4 and
Christian Lindermayr
1,5,*
1
Institute of Biochemical Plant Pathology, Helmholtz Munich, 85764 Oberschleißheim, Germany
2
Genetics, LMU Biocenter, Ludwig-Maximilians-Universität München, 80539 München, Germany
3
Research Unit Analytical Biogeochemistry, Helmholtz Munich, 85764 Oberschleißheim, Germany
4
Chair of Biochemical Plant Pathology, Technische Universität München, 85354 Freising, Germany
5
Institute of Lung Health and Immunity, Comprehensive Pneumology Center, Helmholtz Munich, 85764 Oberschleißheim, Germany
*
Author to whom correspondence should be addressed.
Genes 2023, 14(6), 1199; https://doi.org/10.3390/genes14061199
Submission received: 24 April 2023 / Revised: 23 May 2023 / Accepted: 24 May 2023 / Published: 30 May 2023
(This article belongs to the Special Issue Epigenetic and Transcriptomal Regulatory Mechanisms in ROS- and Phytohormone-Dependent Regulation of Plant Development)
Browse Figures
Review Reports Versions Notes

Abstract

Histone deacetylation catalyzed by histone deacetylase plays a critical role in gene silencing and subsequently controls many important biological processes. It was reported that the expression of the plant-specific histone deacetylase subfamily HD2s is repressed by ABA in Arabidopsis. However, little is known about the molecular relationship between HD2A/HD2B and ABA during the vegetative phase. Here, we describe that the hd2ahd2b mutant shows hypersensitivity to exogenous ABA during the germination and post-germination period. Additionally, transcriptome analyses revealed that the transcription of ABA-responsive genes was reprogrammed and the global H4K5ac level is specifically up-regulated in hd2ahd2b plants. ChIP-Seq and ChIP-qPCR results further verified that both HD2A and HD2B could directly and specifically bind to certain ABA-responsive genes. As a consequence, Arabidopsis hd2ahd2b plants displayed enhanced drought resistance in comparison to WT, which is consistent with increased ROS content, reduced stomatal aperture, and up-regulated drought-resistance-related genes. Moreover, HD2A and HD2B repressed ABA biosynthesis via the deacetylation of H4K5ac at NCED9. Taken together, our results indicate that HD2A and HD2B partly function through ABA signaling and act as negative regulators during the drought resistance response via the regulation of ABA biosynthesis and response genes.
Keywords: Arabidopsis thaliana; drought resistance; histone acetylation; plant-specific histone deacetylases; ABA Arabidopsis thaliana; drought resistance; histone acetylation; plant-specific histone deacetylases; ABA

Share and Cite

MDPI and ACS Style

Han, Y.; Haouel, A.; Georgii, E.; Priego-Cubero, S.; Wurm, C.J.; Hemmler, D.; Schmitt-Kopplin, P.; Becker, C.; Durner, J.; Lindermayr, C. Histone Deacetylases HD2A and HD2B Undergo Feedback Regulation by ABA and Modulate Drought Tolerance via Mediating ABA-Induced Transcriptional Repression. Genes 2023, 14, 1199. https://doi.org/10.3390/genes14061199

AMA Style

Han Y, Haouel A, Georgii E, Priego-Cubero S, Wurm CJ, Hemmler D, Schmitt-Kopplin P, Becker C, Durner J, Lindermayr C. Histone Deacetylases HD2A and HD2B Undergo Feedback Regulation by ABA and Modulate Drought Tolerance via Mediating ABA-Induced Transcriptional Repression. Genes. 2023; 14(6):1199. https://doi.org/10.3390/genes14061199

Chicago/Turabian Style

Han, Yongtao, Amira Haouel, Elisabeth Georgii, Santiago Priego-Cubero, Christoph J. Wurm, Daniel Hemmler, Philippe Schmitt-Kopplin, Claude Becker, Jörg Durner, and Christian Lindermayr. 2023. "Histone Deacetylases HD2A and HD2B Undergo Feedback Regulation by ABA and Modulate Drought Tolerance via Mediating ABA-Induced Transcriptional Repression" Genes 14, no. 6: 1199. https://doi.org/10.3390/genes14061199

APA Style

Han, Y., Haouel, A., Georgii, E., Priego-Cubero, S., Wurm, C. J., Hemmler, D., Schmitt-Kopplin, P., Becker, C., Durner, J., & Lindermayr, C. (2023). Histone Deacetylases HD2A and HD2B Undergo Feedback Regulation by ABA and Modulate Drought Tolerance via Mediating ABA-Induced Transcriptional Repression. Genes, 14(6), 1199. https://doi.org/10.3390/genes14061199

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop