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Volume 13
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10.3390/genes13040622
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Article

Association of Androgenic Regulation and MicroRNAs in Acinar Adenocarcinoma of Prostate

by
Julio Guilherme Balieiro Bernardes
1,2,†,
Marianne Rodrigues Fernandes
2,3,*,†,
Juliana Carla Gomes Rodrigues
2,
Lui Wallacy Morikawa Souza Vinagre
2,
Lucas Favacho Pastana
2,
Elizabeth Ayres Fragoso Dobbin
2,
Jéssyca Amanda Gomes Medeiros
2,
Leonidas Braga Dias Junior
1,
Gabriel Monteiro Bernardes
4,
Izabel Maria Monteiro Bernardes
1,
Ney Pereira Carneiro Dos Santos
2,
Samia Demachki
2 and
Rommel Mario Rodriguez Burbano
2,3
1
Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém 66050-160, Brazil
2
Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém 66073-005, Brazil
3
Hospital Ophir Loyola, Belém 66063-240, Brazil
4
Faculdade de Medicina, Centro Universitário do Estado do Pará, Belém 66613-903, Brazil
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Genes 2022, 13(4), 622; https://doi.org/10.3390/genes13040622
Submission received: 14 February 2022 / Revised: 11 March 2022 / Accepted: 12 March 2022 / Published: 30 March 2022
(This article belongs to the Section Molecular Genetics and Genomics)
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Abstract

Background: Prostate cancer represents 3.8% of cancer deaths worldwide. For most prostate cancer cells to grow, androgens need to bind to a cellular protein called the androgen receptor (AR). This study aims to demonstrate the expression of five microRNAs (miRs) and its influence on the AR formation in patients from the northern region of Brazil. Material and Methods: Eighty-four tissue samples were investigated, including nodular prostatic hyperplasia (NPH) and acinar prostatic adenocarcinoma (CaP). Five miRs (27a-3p, 124, 130a, 488-3p, and 506) were quantified using the TaqMan® Real Time PCR method and AR was measured using Western blotting. Results: Levels of miRs 124, 130a, 488-3p, and 506 were higher in NPH samples. Conversely, in the CaP cases, higher levels of miR 27a-3p and AR were observed. Conclusion: In the future, these microRNAs may be tested as markers of CaP at the serum level. The relative expression of AR was 20% higher in patients with prostate cancer, which suggests its potential as a biomarker for prostate malignancy.
Keywords: nodular hyperplasia of the prostate; acinar carcinoma; androgen receptor; microRNA nodular hyperplasia of the prostate; acinar carcinoma; androgen receptor; microRNA

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MDPI and ACS Style

Bernardes, J.G.B.; Fernandes, M.R.; Rodrigues, J.C.G.; Vinagre, L.W.M.S.; Pastana, L.F.; Dobbin, E.A.F.; Medeiros, J.A.G.; Dias Junior, L.B.; Bernardes, G.M.; Bernardes, I.M.M.; et al. Association of Androgenic Regulation and MicroRNAs in Acinar Adenocarcinoma of Prostate. Genes 2022, 13, 622. https://doi.org/10.3390/genes13040622

AMA Style

Bernardes JGB, Fernandes MR, Rodrigues JCG, Vinagre LWMS, Pastana LF, Dobbin EAF, Medeiros JAG, Dias Junior LB, Bernardes GM, Bernardes IMM, et al. Association of Androgenic Regulation and MicroRNAs in Acinar Adenocarcinoma of Prostate. Genes. 2022; 13(4):622. https://doi.org/10.3390/genes13040622

Chicago/Turabian Style

Bernardes, Julio Guilherme Balieiro, Marianne Rodrigues Fernandes, Juliana Carla Gomes Rodrigues, Lui Wallacy Morikawa Souza Vinagre, Lucas Favacho Pastana, Elizabeth Ayres Fragoso Dobbin, Jéssyca Amanda Gomes Medeiros, Leonidas Braga Dias Junior, Gabriel Monteiro Bernardes, Izabel Maria Monteiro Bernardes, and et al. 2022. "Association of Androgenic Regulation and MicroRNAs in Acinar Adenocarcinoma of Prostate" Genes 13, no. 4: 622. https://doi.org/10.3390/genes13040622

APA Style

Bernardes, J. G. B., Fernandes, M. R., Rodrigues, J. C. G., Vinagre, L. W. M. S., Pastana, L. F., Dobbin, E. A. F., Medeiros, J. A. G., Dias Junior, L. B., Bernardes, G. M., Bernardes, I. M. M., Santos, N. P. C. D., Demachki, S., & Burbano, R. M. R. (2022). Association of Androgenic Regulation and MicroRNAs in Acinar Adenocarcinoma of Prostate. Genes, 13(4), 622. https://doi.org/10.3390/genes13040622

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